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RISS 인기검색어
- 검색키워드
- 저자 : Lan Kluwe (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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The feasibility of immediately loading dental implants in edentulous jaws
Henningsen, Anders,Smeets, Ralf,Wahidi, Aria,Kluwe, Lan,Kornmann, Frank,Heiland, Max,Gerlach, Till Korean Academy of Periodontology 2016 Journal of Periodontal & Implant Science Vol.46 No.4
Purpose: Immediate loading of dental implants has been proved to be feasible in partially edentulous jaws. The purpose of this retrospective investigation was to assess the feasibility of immediately loading dental implants in fully edentulous jaws. Methods: A total of 24 patients aged between 53 and 89 years received a total of 154 implants in their edentulous maxillae or mandibles. Among the implants, 45 were set in fresh extracted sockets and 109 in consolidated alveolar bones. The implants were provisionally managed with chair-side made provisional resin bridges and exposed to immediate loading. Implants were followed up for 1-8 years, including radiographic imaging. Marginal bone levels were evaluated based on radiographic imaging. Results: A total of 148 out of the 154 implants survived over the follow-up period of 1 to 8 years, giving a survival rate of 96%. The time or region of the implantation, the pre-implant augmentation, and the length and diameter of the implants had no statistically significant influence on the survival or the success rate. The marginal bone level remained stable with only minimal loss of 0.3 mm after 60 months of loading. Conclusions: Within the limitations of this study, immediate loading is feasible for dental implants in edentulous jaws.
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The feasibility of immediately loading dental implants in edentulous jaws
Anders Henningsen,Ralf Smeets,Aria Wahidi,Lan Kluwe,Frank Kornmann,Max Heiland,Till Gerlach 대한치주과학회 2016 Journal of Periodontal & Implant Science Vol.46 No.4
Purpose: Immediate loading of dental implants has been proved to be feasible in partially edentulous jaws. The purpose of this retrospective investigation was to assess the feasibility of immediately loading dental implants in fully edentulous jaws. Methods: A total of 24 patients aged between 53 and 89 years received a total of 154 implants in their edentulous maxillae or mandibles. Among the implants, 45 were set in fresh extracted sockets and 109 in consolidated alveolar bones. The implants were provisionally managed with chair-side made provisional resin bridges and exposed to immediate loading. Implants were followed up for 1–8 years, including radiographic imaging. Marginal bone levels were evaluated based on radiographic imaging. Results: A total of 148 out of the 154 implants survived over the follow-up period of 1 to 8 years, giving a survival rate of 96%. The time or region of the implantation, the pre-implant augmentation, and the length and diameter of the implants had no statistically significant influence on the survival or the success rate. The marginal bone level remained stable with only minimal loss of 0.3 mm after 60 months of loading. Conclusions: Within the limitations of this study, immediate loading is feasible for dental implants in edentulous jaws.
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Effector T cell subclasses associate with tumor burden in neurofibromatosis type 1 patients
Farschtschi, Said,Park, Su-Jin,Sawitzki, Birgit,Oh, Su-Jun,Kluwe, Lan,Mautner, Victor F.,Kurtz, Andreas Springer Berlin Heidelberg 2016 Cancer immunology, immunotherapy Vol.65 No.9
<P>Neurofibromatosis type 1 (NF1) is a hereditary tumor syndrome caused by mutations of the <I>NF1</I> gene and resulting dysregulation of the Ras-pathway. In addition to peripheral nerve tumors, affected tissues include the musculoskeletal and cardiovascular system. The immune system has recently been suggested as a possible modulator NF1-related phenotypes. Therefore, we determined the immune phenotype in NF1 patients and investigated its relationship with the phenotypic severity of NF1-related tumor manifestations. We quantified global leukocytes and lymphocyte subpopulations of peripheral blood from 37 NF1 patients and 21 healthy controls by flow cytometry. To associate immune phenotype with tumor phenotype, all NF1 patients underwent whole-body magnetic resonance imaging and total internal tumor volume was calculated. The immunophenotypes were compared among four NF1 groups with different total internal tumor burdens and between NF1 patients and non-NF1 subjects. We found that NF1 patients show a generalized lymphopenia. Closer analysis revealed that the CD8<SUP>+</SUP>/CD27<SUP>−</SUP> and CD8<SUP>+</SUP>/CD57<SUP>+</SUP> effector T cell fractions strongly increase in NF1 patients with low tumor load and decrease to levels below control in patients with high tumor load. Moreover, increased production of IL2, IFN-γ and TNF-α was found in T cells of NF1 patients upon phorbol-12-myristate acetate (PMA) stimulation compared to healthy controls. The data indicate that decreasing CD8<SUP>+</SUP>/CD57<SUP>+</SUP> and CD27<SUP>−</SUP> T cell fractions correspond to increasing tumor load in NF1 patients, potentially making these populations useful marker for internal tumor burden.</P>
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Wei Jiang,Victor-F. Mautner,Reinhard E. Friedrich,Lan Kluwe 대한신경과학회 2015 Journal of Clinical Neurology Vol.11 No.2
Background and Purpose Individualized drug testing for tumors using a strategy analogous to antibiotic tests for infectious diseases would be highly desirable for personalized andindividualized cancer care. Methods Primary cultures containing tumor and nontumor stromal cells were utilized in anovel strategy to test drug responses with respect to both efcacy and specifcity. Te strategytested in this pilot study was implemented using four primary cultures derived from plexiformneurofbromas. Responses to two cytotoxic drugs (nilotinib and imatinib) were measured byfollowing dose-dependent changes in the proportions of tumor and nontumor cells, determined by staining them with cell-type-specifc antibodies. Te viability of the cultured cellsand the cytotoxic efect of the drugs were also measured using proliferation and cytotoxicityassays. Results Te total number of cells decreased afer the drug treatment, in accordance with theobserved reduction in proliferation and increased cytotoxic efect upon incubation with thetwo anticancer drugs. Te proportions of Schwann cells and fbroblasts changed dose-dependently, although the patterns of change varied between the tumor samples (from diferent sources) and between the two drugs. Te highly variable in vitro drug responses probably refect thelarge variations in the responses of tumors to therapies between individual patients in vivo. Conclusions Tese preliminary results suggest that the concept of assessing in vitro drug responses using primary cultures is feasible, but demands the extensive further development ofan application for preclinical drug selection and drug discovery.
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