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- 저자 : Laila A. Rashad (검색결과 1 건)
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Shahira M. Ezzat,Maha M. Salama,Aliaa N. ElMeshad,Mahmoud H. Teaima,Laila A. Rashad 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.7
The anti-wrinkle activity of defatted rosemaryextract (DER) was assessed, and its effect was optimized byencapsulation in transferosomes (TFs). DER was standardizedto a rosmarinic acid content of 4.58 ± 0.023 mg%using reversed-phase high performance liquid chromatography(Rp-HPLC), and its components were identified byHPLC-diode array detection-tandem mass spectrometry. In vitro free radical scavenging assays showed DER hadhigh free radical scavenging activity against 2,2-diphenyl-2-picryl hydrazyl, 2,20-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), and superoxide radicals. DER also inhibitedbleaching of b-carotene with high Fe(III) and Fe(II)chelating ability. In vivo anti-wrinkle activities of topicallyapplied DER (20, 50, and 100 mg) and a TF formulation(TF4, 20 mg of DER) were evaluated in UVB-irradiatedmice using a wrinkle scoring method, metalloproteinase(MMP) expression, and histopathology. Among thenanovesicles, TF4 was the most deformable, and had anacceptable size and encapsulation efficiency and enhancedpermeation of DER through rat skin compared with unencapsulatedDER. DER (50 and 100 mg) and TF4 significantlyinhibited MMP-2 and MMP-9 expression andimproved wrinkle scores. DER and TF4 moderatelydecreased epidermal thickness without pigmentation. DERis a potent natural antioxidant for combating skin aging. Moreover, encapsulation of DER in TFs will enhance itsskin permeation and anti-wrinkle activity.
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