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      • Neurotransmitter identity of the developing midbrain

        LOI DUC LINH KyungHee university 2018 국내석사

        RANK : 233039

        The midbrain is the smallest region and play a critical role in the central nervous system that acts as a sort of relay station for auditory and visual information. It controls many important functions such as the visual and auditory systems as well as eye movement. Dbx1 is a group of transcription factor involved in neuronal fate specification belonging to a widely conserved family among bilaterians and Dbx1 also controls the formation of neural networks governing physiological functions which were fundamental during mammalian evolution. Although Dbx1 is widely expressed all the region of the mouse brain, the role of Dbx1 in brain development in the midbrain remains poorly understood. In this study, Our data showed the expression pattern of Dbx1 in the mouse midbrain. Besides, we generated Dbx1-null mutant mice and confirmed the null phenotype by the complete loss of Dbx1 expression in the homozygous mutant (Dbx1/) embryos. Using this mouse line, we demonstrate that Dbx1 was selectively expressed in GABAergic and glutamatergic neurons in the midbrain. Moreover, Dbx1 activity appears to be required for suppression of glutamatergic neurons generation as well as for induction of GABAergic neurons.

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