http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Kwangjay Yoo (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Sympathetic Regulation of Aquaporin Water Channels in Rat Kidney
JongUn Lee,Kwangjay Yoo,YoonWha Oh,Dong Yoon Lim 대한생리학회-대한약리학회 2003 The Korean Journal of Physiology & Pharmacology Vol.5 No.1
Whether there exists a sympathetic neural regulation on the aquaporin (AQP) channels in the kidney was examined. Male Sprague-Dawley rats were used. They were renal nerve denervated by stripping the nervous and connective tissues passing along the renal artery and vein, and painting these vessels with 10% phenol solution through a midline abdominal incision. Three days later, the expression of AQP1-4 proteins in the denervated kidneys was determined. The content of norepinephrine was found significantly decreased following the denervation. Accordingly, the expression of AQP2 proteins was markedly decreased. The expression of AQP3 and AQP4 was also slightly but significantly decreased, while that of AQP1 was not. Neither the basal nor the AVP-stimulated accumulation of cAMP was significantly affected in the denervated kidney. It is suggested that the sympathetic nervous system has a tonic stimulatory effect on AQP channels in the kidney.
-
Decreased Expression of Aquaporin Water Channels in Denervated Rat Kidney
Lee, JongUn,Yoo, Kwangjay,Kim, Soo Wan,Jung, Kyoon Ho,Ma, Seong Kwon,Lee, Yeon Kyung,Kim, Wan-Young,Kim, Jin,Choi, Ki Chul S. Karger AG 2006 Nephron Vol.103 No.4
<P><I>Aims:</I> A neural mechanism regulating aquaporin (AQP) water channels in the kidney was investigated. <I>Methods:</I> Male Sprague-Dawley rats were used. Renal denervation was induced by painting the renal vessels with 10% phenol. The expression of AQP1-4 proteins was determined in the denervated and contralateral kidneys. The expression was also examined in rats which were renally denervated and subjected to water restriction or deoxycorticosterone acetate (DOCA)-salt treatment. <I>Results:</I> Following the unilateral denervation, tissue contents of norepinephrine were significantly decreased in the denervated kidney, while increased in the contralateral kidney. Accordingly, the expression of AQP1-4 proteins was decreased by 15-40% in the denervated kidney, and increased by 30-50% in the contralateral kidney. Immunohistochemistry of AQP2 confirmed its decreases in the denervated kidney and increases in the contralateral kidney. In bilaterally denervated rats, the urine flow increased along with decreased osmolarity. The water restriction increased the expression of AQP channels, however, the magnitude of which was lower in the denervated than in the contralateral kidney. Renal denervation decreased the degree of DOCA-salt hypertension, along with lower expression of AQP channels. <I>Conclusion:</I> It is suggested that the sympathetic nerve should play a specific excitatory role in the regulation of AQP channels in the kidney.</P><P>Copyright © 2006 S. Karger AG, Basel</P>
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
