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Ota, Miho,Ogura, Jun,Ogawa, Shintaro,Kato, Koichi,Matsuda, Hiroshi,Kunugi, Hiroshi 대한핵의학회 2018 핵의학 분자영상 Vol.52 No.3
Purpose Intracranial administration of lipopolysaccharide (LPS) is known to elicit a rapid innate immune response, activate glial cells in the brain, and induce depression-like behavior. However, no study has focused on the changes in glial cells induced by intraperitoneal injection of LPS in vivo. Methods Ten adult male Fischer F344 rats underwent [$^{11}C$]PK11195 PET before and 2 days after intraperitoneal injection of LPS to evaluate the changes in glial cells. The difference in standardized uptake values (SUV) of [$^{11}C$]PK11195 between before and after injection was determined. Results There was a cluster of brain regions that showed significant reductions in SUV. This cluster included the bilateral striata and bilateral frontal regions, especially the somatosensory areas. Conclusions Changes in activity of glial cells induced by the intraperitoneal injection of LPS were detected in vivo by [$^{11}C$]PK11195 PET. Intraperitoneal injection of LPS is known to induce depression, and further studies with [$^{11}C$]PK11195 PET would clarify the relationships between neuroinflammation and depression.
New Method to Measure the Rise Time of a Fast Pulse Slicer for Laser Ion Acceleration Research
Mori, Michiaki,Yogo, Akifumi,Kiriyama, Hiromitsu,Nishiuchi, Mamiko,Ogura, Koichi,Orimo, Satoshi,Ma, Jinglong,Sagisaka, Akito,Kanazawa, Shuhei,Kondo, Shuji,Nakai, Yoshiki,Akutsu, Atsushi,Yamamoto, Yoic IEEE 2008 IEEE transactions on plasma science Vol.36 No.4
<P> A dependence of cutoff proton kinetic energy on laser prepulse duration has been observed. Amplified spontaneous emission pedestal duration is controlled by a fast electrooptic pulse slicer where the rise time is estimated to be 130 ps. We demonstrate a new correlated spectral technique for determining this rise time using a stretched frequency-chirped pulse. </P>
Development of Laser-driven Proton Source Toward Its Applications
Akito Sagisaka,Hiroyuki Daido,Alexander S. Pirozhkov,Akifumi Yogo,Koichi Ogura,Satoshi Orimo,Jinglong Ma,Michiaki Mori,Mamiko Nishiuchi,Sergei V. Bulanov,Timur Zh. Esirkepov,Yuji Oishi,Takuya Nayuki,T 한국광학회 2009 Current Optics and Photonics Vol.13 No.1
We observe the proton signals produced by laser interaction with thin-foil targets of polyimide and of copper. We change the thickness of the polyimide target to 7.5 μm, 12.5 μm, and 50 μm. High-energy protons with the maximum energy of ~2.3 MeV from 7.5 μm thick polyimide are observed. This proton beam with the maximum energy of multi-MeV has various applications such as a proton shadowgraphy.