http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Indy Smits ),( Niek Koenders ),( Vincent Stirler ),( Erik Hermans ) 대한고관절학회 2023 Hip and Pelvis Vol.35 No.2
Purpose: Isolated acetabular fractures can occur as a result of a high energy impact on the hip joint. Surgery is required for most patients with an isolated acetabular fracture in order to alleviate pain, restore joint stability, and regain hip function. This study was conducted in order to examine the course of hip function in patients after surgical treatment of an isolated traumatic acetabular fracture. Materials and Methods: This prospective series of consecutive cases included patients who underwent surgery for treatment of an isolated acetabular fracture in a European level one trauma center between 2016 and 2020. Patients with relevant concomitant injuries were excluded. Scoring of hip function was performed by a trauma surgeon using the Modified Merle d’Aubigné and Postel score at six-week, 12-week, six-month, and one-year follow-up. Scores between 3-11 indicate poor, 12-14 fair, 15-17 good, and 18 excellent hip function. Results: Data on 46 patients were included. The mean score for hip function was 10 (95% confidence interval [CI] 7.09-12.91) at six-week follow-up (23 patients), 13.75 (95% CI 10.74-16.76) at 12-week follow-up (28 patients), 16 (95% CI 13.40-18.60) at six-month follow-up (25 patients), and 15.50 (95% CI 10.55-20.45) at oneyear follow-up (17 patients). After one-year follow-up, the scores reflected an excellent outcome in 11 patients, good in five patients, and poor in one patient. Conclusion: This study reports on the course of hip function in patients who have undergone surgical treatment for isolated acetabular fractures. Restoration of excellent hip function takes six months.
Numerical simulations of progression of damage in concrete embedded chemical anchors
S. Sasmal,R. Thiyagarajan,K.H. Lieberum,E.A.B. Koenders 사단법인 한국계산역학회 2018 Computers and Concrete, An International Journal Vol.22 No.4
In this paper, the performance of post-installed adhesive bonded anchor embedded in concrete is assessed using numerical simulations. This study aims at studying the influence of parameters on the performance of a chemically bonded anchorage system. Non-linear finite element modelling and simulations are carried out by properly using the material properties and phenomenon. Materials parameters such as characteristic length, fracture energy, damage criteria, tension retention and crack width of concrete and interface characteristics are carefully assigned so as to obtain a most realistic behaviour of the chemical anchor system. The peak strength of two different anchor systems obtained from present numerical studies is validated against experimental results. Furthermore, validated numerical models are used to study the load transferring mechanism and damage progression characteristics of various anchors systems where strength of concrete, strength of epoxy, and geometry and disposition of anchors are the parameters. The process of development of strain in concrete adjacent to the anchor and energy dissipated during the course of damage progression are analysed. Results show that the performance of the considered anchorage system is, though a combined effect of material and geometric parameters, but a clear distinction could be made on the parameters to achieve a desired performance based on strength, slip, strain development or dissipated energy. Inspite the increase in anchor capacity with increase in concrete strength, it brings some undesirable performance as well. Furthermore, the pullout capacity of the chemical anchor system increases with a decrease in disparity among the strength of concrete and epoxy.
Joosten, Leo A B,Crisan, Tania O,Azam, Tania,Cleophas, Maartje C P,Koenders, Marije I,van de Veerdonk, Frank L,Netea, Mihai G,Kim, Soohyun,Dinarello, Charles A BMJ Publishing Group Ltd 2016 Annals of the Rheumatic Diseases Vol.75 No.6
<P>Objectives In the present study, we generated a new protein, recombinant human alpha-1-anti-trypsin (AAT)-IgG1 Fc fusion protein (AAT-Fc), and evaluated its properties to suppress inflammation and interleukin (IL)-1 beta in a mouse model of gouty arthritis. Methods A combination of monosodium urate (MSU) crystals and the fatty acid C16.0 (MSU/C16.0) was injected intra-articularly into the knee to induce gouty arthritis. Joint swelling, synovial cytokine production and histopathology were determined after 4 h. AAT-Fc was evaluated for inhibition of MSU/C16.0-induced IL-1 beta release from human blood monocytes and for inhibition of extracellular IL-1 beta precursor processing. Results AAT-Fc markedly suppressed MSU/C16.0-induced joint inflammation by 85-91% (p<0.001). Ex vivo production of IL-1 beta and IL-6 from cultured synovia were similarly reduced (63% and 65%, respectively). The efficacy of 2.0 mg/kg AAT-Fc in reducing inflammation was comparable to 80 mg/kg of plasma-derived AAT. Injection of AAT-Fc into mice increased circulating levels of endogenous IL-1 receptor antagonist by fourfold. We also observed that joint swelling was reduced by 80%, cellular infiltration by 95% and synovial production of IL-1 beta by 60% in transgenic mice expressing low levels of human AAT. In vitro, AAT-Fc reduced MSU/C16.0-induced release of IL-1 beta from human blood monocytes and inhibited proteinase-3-mediated extracellular processing of the IL-1 beta precursor into active IL-1 beta. Conclusions A single low dose of AAT-Fc is highly effective in reducing joint inflammation in this model of acute gouty arthritis. Considering the long-term safety of plasma-derived AAT use in humans, subcutaneous AAT-Fc emerges as a promising therapy for gout attacks.</P>