Real-time Wind Power Prediction System Based on Smart-Grid in Jeju, Korea

Kim, Kwon,Seo, Young-Jun,Moon, Kyoung-Seob,Lee, Young-Mi The Korean Institute of Electrical Engineers 2012 The Journal of International Council on Electrical Vol.2 No.2

Wind power prediction information is necessary for electric power system operation and electricity power market which is allowed to participate the wind power. In this study, a real-time wind power prediction system is designed for the real application for the electric power system of Smart-Grid Test Bed in Jeju island, South Korea. This study is on the first system for practicable application of wind power to the electric power system operation in South Korea. This is composed of the meteorological forecasting module, calculation module of wind power output and HMI visualization system. The final output data from this system is short-term (6hr ahead) and mid-term (48hr ahead) wind power prediction values. These values are produced by using physical and statistical model. The purpose of this study is to further improve the accuracy of this prediction system and to develop practical system for power system operation and energy market in Smart-Grid.

Effect of Neurotrophic Factors on Neuronal Stem Cell Death

KimKwon, Yun-Hee Korean Society for Biochemistry and Molecular Biol 2002 Journal of biochemistry and molecular biology Vol.35 No.1

Neural cell survival is an essential concern in the aging brain and many diseases of the central nervous system. Neural transplantation of the stem cells are already applied to clinical trials for many degenerative neurological diseases, including Huntington's disease, Parkinson's disease, and strokes. A critical problem of the neural transplantation is how to reduce their apoptosis and improve cell survival. Neurotrophic factors generally contribute as extrinsic cues to promote cell survival of specific neurons in the developing mammalian brains, but the survival factor for neural stem cell is poorly defined. To understand the mechanism controlling stem cell death and improve cell survival of the transplanted stem cells, we investigated the effect of plausible neurotrophic factors on stem cell survival. The neural stem cell, HiB5, when treated with PDGF prior to transplantation, survived better than cells without PDGF. The resulting survival rate was two fold for four weeks and up to three fold for twelve weeks. When transplanted into dorsal hippocampus, they migrated along hippocampal alveus and integrated into pyramidal cell layers and dentate granule cell layers in an inside out sequence, which is perhaps the endogenous pathway that is similar to that in embryonic neurogenesis. Promotion of the long term-survival and differentiation of the transplanted neural precursors by PDGF may facilitate regeneration in the aging adult brain and probably in the injury sites of the brain.

Efficient Gene Delivery through the Human Transferrin Receptor of Fibroblast-like Synoviocytes Stimulated with bFGF: a Potential Target Receptor for Gene Transduction in Rheumatoid Arthritis

Kim, Hak-Jae,Joung, In-Sil,Nah, Seong-Su,Lee, Kyu-Hoon,KimKwon, Yun-Hee,Chung, Joo-Ho,Hong, Seung-Jae The Korean Society of Toxicogenomics and Toxicopro 2007 Molecular & cellular toxicology Vol.3 No.2

Efficient gene delivery to specific tissues, such as inflammatory and cancerous tissues, is currently a major concern in disease treatment. The human transferrin receptor (hTR) has been detected in the synovium and fibroblast-like synoviocytes (FLS), which raises the possibility that expression of hTR is associated with the pathogenesis of rheumatoid arthritis (RA). To investigate whether the hTR is a useful target for gene transduction into the FLS of RA patients, recombinant adenoviruses with wildtype fiber (AdLac) and transferrin peptide-tagged fiber (Tf-AdLac) were used. The hTR expression level in FLS was notably increased by basic fibroblast growth factor (bFGF). Gene transduction to FLS was significantly higher by the hTR-targeted adenovirus than by the AdLac adenovirus, and treatment of the FLS with bFGF resulted in increased gene transduction by Tf-AdLac. Taken together, these data support Tf-AdLac as a new strategy for gene transduction in the treatment of RA patients.

Shp2 is Involved in Neuronal Differentiation of Hippocampal Precursor Cells

Kim, Hak-Jae,Han, Ah-Mi,Shim, Jae-Hwan,Yoon, Hye-Hyun,Kwon, Hyock-Man,Kimkwon, Yun-Hee 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.6

HiB5 is a multipotent hippocampal stem cell line whose differentiation into cells of a neuronal phenotype is promoted by neurotrophic factors such as PDGF and brain-derived neurotrophicfactor (BDNF). We examined the potential role of Src homology 2 (SH2)-containing protein tyrosine phosphatase (Shp2) in this differentiation process. We found that Shp2 became tyrosine phosphoulated following PDGF treatment. Wild-type Shp2 enhanced the expression of neurofilament, synapsin I and PSD95 by PDGF and BDNF, whereas their expression was attenuated by the catalytically inactive mutants Shp2C/S and Shp2${\Delta}$P. Formation of dendritic spine-like structures increased with wild-type Shp2, but diminished with Shp2C/S and Shp2${\Delta}$P. PSD95, localized in the post-synaptic density region of dendritic spines, PDGFR${\beta}$ and TrkB were co-immunoprecipitated with Shp2 antibodies. These results suggest that Shp2 plays a positive role in mediating PDGF- and BDNF-activated signaling which promotes the formation of dendritic spines.

Secretion of EGF-Like Domain of Heregulin${\beta}$ Promotes Axonal Growth and Functional Recovery of Injured Sciatic Nerve

Joung, In-Sil,Yoo, Min-Joo,Woo, Ji-Hyoun,Chang, Chi-Young,Heo, Hwon,KimKwon, Yun-Hee Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.30 No.5

Neuregulin 1 (NRG1) and epidermal growth factor receptor (ErbB) signaling pathways control Schwann cells during axonal regeneration in an injured peripheral nervous system. We investigated whether a persistent supply of recombinant NRG1 to the injury site could improve axonal growth and recovery of sensory and motor functions in rats during nerve regeneration. We generated a recombinant adenovirus expressing a secreted form of EGF-like domain from Heregulin${\beta}$ (sHRG${\beta}$E-Ad). This virus, sHRG${\beta}$EAd allowed for the secretion of 30-50 ng of small sHRG${\beta}$E peptides per $10^{7-8}$ virus particle outside cells and was able to phosphorylate ErbB receptors. Transduction of the concentrated sHRG${\beta}$E-Ad into an axotomy model of sciatic nerve damage caused an effective promotion of nerve regeneration, as shown by histological features of the axons and Schwann cells, as well as increased expression of neurofilaments, GAP43 and S100 in the distal stump of the injury site. This result is consistent with longer axon lengths and thicker calibers observed in the sHRG${\beta}$E-Ad treated animals. Furthermore, sensory and motor functions were significantly improved in sHRG${\beta}$E-Ad treated animals when evaluated by a behavioral test. These results suggest a therapeutic potential for sHRG${\beta}$E-Ad in treatment of peripheral nerve injury.

Decrease of c-Fos Expression in Hippocampus of Anorexia(anx/anx) Mice

Kim, Soon Ae,Choi, Young Mee,Park, Hi-Joon,Lee, Hyangsook,Han, Jin A,Kang, Soon Ah,Choue, Ryo Won,KimKwon, Yunhee,Kim, Chang-Ju,Chung, Joo-Ho The Korean Society for Integrative Biology 2001 Korean journal of biological sciences Vol.5 No.2

Mice homozygous for the lethal autosomal recessive anorexia mutation (anx) present with premature death around postnatal day 22. The anorexia mutant mice also present phenotypes such as reduced body weight, decreased food intake, and abnormal behavior characteristics such as body tremors, hyperactivity, uncoordinated gait, and head weaving. In order to investigate the expression of c-Fos in the hippocampus of anorexia mutant mice, the immunohistochemistry was performed in this study. The anorexia mutant mice exhibited lower expression of c-Fos in the hippocampus regions thBn the control group. In the CA3 and dentate gyrus, the number of c-Fos-positive cells in anorexia mutant mice was noticeably lower than that in control mice. However, no significant difference was found in the number of c-Fos-positive cells in CA1 of the two groups. The result suggests that the phenotypic characteristics of anorexia mutant mice may be associated with the hippocampal deficits of c-Fos expression.