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RISS 인기검색어
- 검색키워드
- 저자 : Khaiereddine Ben Mahfoudh (검색결과 2 건)
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Impact of prone position on outcomes of COVID-19 patients with spontaneous breathing
Mabrouk Bahloul,Sana Kharrat,Malek Hafdhi,Anis Maalla,Olfa Turki,Kamilia Chtara,Rania Ammar,Basma Suissi,Chokri Ben Hamida,Hedi Chelly,Khaiereddine Ben Mahfoudh,Mounir Bouaziz 대한중환자의학회 2021 Acute and Critical Care Vol.36 No.3
Background: In this study, we explored whether early application of the prone position (PP) can improve severe hypoxemia and respiratory failure in coronavirus disease 2019 (COVID-19) patients with spontaneous breathing. Methods: This is a prospective observational study of severe, critically ill adult COVID-19 patients admitted to the intensive care unit. All vital parameters were recorded in real time for all patients. Moreover, the results of chest computed tomography (CT), when available, were analyzed. Results: PP was applied in 21 patients who were breathing spontaneously. The application of PP was associated with a significant increase in oxygen saturation measured by pulse oximetry (SpO2) from 82%±12% to 96%±3% (P<0.001) 1 hour later. Moreover, PP was associated with a significant reduction in respiratory rate from 31±10 to 21±4 breaths/min (P<0.001). Furthermore, the number of patients who exhibited signs of respiratory distress after PP was reduced from 10 (47%) to 3 (14%) (P=0.04). Early PP application also led to a clear improvement on CT imaging. It was not, however, associated with a reduction in mortality rate or in the use of invasive mechanical ventilation (P>0.05 for both). Conclusions: Our study confirmed that the early application of PP can improve hypoxemia and tachypnea in COVID-19 patients with spontaneous breathing. Randomized controlled trials are needed to confirm the beneficial effects of PP in COVID-19 patients with spontaneous breathing.
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Clinical characteristics and outcomes of critically ill COVID-19 patients in Sfax, Tunisia
Mabrouk Bahloul,Sana Kharrat,Kamilia Chtara,Malek Hafdhi,Olfa Turki,Najeh Baccouche,Rania Ammar,Nozha Kallel,Majdi Hsairi,Olfa Chakroun-Walha,Chokri Ben Hamida,Hedi Chelly,Khaiereddine Ben Mahfoudh,Ab 대한중환자의학회 2022 Acute and Critical Care Vol.37 No.1
Background: Africa, like the rest of the world, has been impacted by the coronavirus disease 2019 (COVID-19) pandemic. However, only a few studies covering this subject in Africa have been published. Methods: We conducted a retrospective study of critically ill adult COVID-19 patients—all of whom had a confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection—admitted to the intensive care unit (ICU) of Habib Bourguiba University Hospital (Sfax, Tunisia). Results: A total of 96 patients were admitted into our ICU for respiratory distress due to COVID-19 infection. Mean age was 62.4±12.8 years and median age was 64 years. Mean PaO2/FiO2 ratio was 105±60 and ≤300 in all cases but one. Oxygen support was required for all patients (100%) and invasive mechanical ventilation for 38 (40%). Prone positioning was applied in 37 patients (38.5%). Within the study period, 47 of the 96 patients died (49%). Multivariate analysis showed that the factors associated with poor outcome were the development of acute renal failure (odds ratio [OR], 6.7), the use of mechanical ventilation (OR, 5.8), and serum cholinesterase (SChE) activity lower than 5,000 UI/L (OR, 5.9). Conclusions: In this retrospective cohort study of critically ill patients admitted to the ICU in Sfax, Tunisia, for acute respiratory failure following COVID-19 infection, the mortality rate was high. The development of acute renal failure, the use of mechanical ventilation, and SChE activity lower than 5000 UI/L were associated with a poor outcome.
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