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RISS 인기검색어
- 검색키워드
- 저자 : Keshavarz Seyed Ali (검색결과 4 건)
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Akhondzadeh Shahin,Mostafavi Seyed-Ali,Keshavarz Seyed Ali,Mohammadi Mohammad Reza,Chamari Maryam 대한수면학회 2022 sleep medicine research Vol.13 No.1
Background and Objective Co-morbidity of obesity, sleep disturbance, and depression is common, especially among women. We aimed to evaluate the effects of melatonin on body weight, depression symptoms and sleep among women with co-morbidities of obesity, mild and moderate depression, and sleep disturbances seeking weight reduction compared with the placebo.Methods This double-blind, randomized clinical trial was performed on 43 patients with comorbidity of mild and moderate depression, overweight/obesity (body mass index ≥ 25) and sleep disturbance. After obtaining the informed consent forms they were randomly assigned to receive 3 mg melatonin or placebo at bed-time. We performed body composition assessments, Beck Depression Inventory, Spielberger State-Trait Anxiety Inventory and Pittsburgh Sleep Quality Index at the baseline, and 2, 4, 8, and 12 weeks after initiating of the study. We analyzed the data using analysis of variance repeated measures.Results Melatonin significantly reduced depression symptoms compared with the placebo, F = (1, 34) = 6.2, p = 0.017. Also, melatonin significantly improved sleep quality, F = (1, 33) = 8.0, p = 0.008. Besides, subjects on the melatonin reduced more weight compared with the placebo but difference between groups was not significant, F = (1, 41) = 0.2, p = 0.650. Patients in the melatonin group did not show significantly more side effects compared to placebo.Conclusions Based on our findings, melatonin was not able to significantly reduce the body weight more than placebo, but as a safe over-the-counter supplement, it may be helpful in patients with co-morbidities of sleep disturbance, mild and moderate depression, and obesity in reducing the symptoms of depression and insomnia.
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Association Between Infants Anthropometric Outcomes With Maternal AHEI-P and DII Scores
Zahra Roumi,Abolghassem Djazayery,Seyed Ali Keshavarz 한국임상영양학회 2023 Clinical Nutrition Research Vol.12 No.2
The present study sought to examine the association between an infant’s anthropometric outcomes with maternal Dietary Inflammatory Index (DII) and Alternate Healthy Eating Index for Pregnancy (AHEI-P) scores during the third trimester of pregnancy. This prospective cohort study was applying 130 pregnant women, at the pregnancy training center in west Tehran, Iran (November 2020 to July 2021). The maternal dietary intake, and body mass index (BMI), and social economic level were evaluated. The data about birth weight, birth height, head circumference, and, gestational age at birth were extracted from each child’s health records. The ultimate sample included 122 (93.8%) pairs of women/newborn children. The participants, mean age was 28.13 ± 4.66 years with gestational age between 28 to 40 weeks and the mean of BMI was 24.62 ± 3.51. Our outcomes, after adjustment for confounding factors, suggested that those newborn infants in the highest quartile of maternal DII score had a significantly lower weight (p < 0.001) and height (p = 0.05), in comparison to those in the lowest quartile, but not head circumference (p = 0.18). Moreover, after adjustment for confounding factors, results suggested that those newborn infants in the First quartile of maternal AHEI-P score had a significantly lower weight (p = 0.018) and, in comparison to those in the higher quartile. It appears that newborn infants with lower maternal DII and higher AHEI-P scores may have a better anthropometric outcome. Further longitudinal and in-depth qualitative and quantitative studies, with a longer-term follow-up, is warranted to support the integrity of our outcomes.
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( Hadith Tangestani ),( Hadi Emamat ),( Mir Saeed Yekaninejad ),( Seyed Ali Keshavarz ),( Khadijeh Mirzaei ) 한국임상영양학회 2021 Clinical Nutrition Research Vol.10 No.1
Circadian disruption causes obesity and other metabolic disorders. There is no research considering the role of Cryptochromes (Cry) 1 body clock gene and major dietary patterns on serum leptin level and obesity. We aimed to investigate the interaction between Cry1 circadian gene polymorphisms and major dietary patterns on leptin and obesity related measurements. This study was performed on 377 overweight and obese women. Mean age and body mass index (BMI) of study subjects were 36.64 ± 9.02 years and 30.81 ± 3.8 kg/m<sup>2</sup>, respectively. Dietary assessment was done using a validated 147-item food frequency questionnaire. Cry1 rs2287161 were genotyped using polymerase chain reaction-restriction fragment length polymorphism. Generalized linear models were used for interaction analysis. Healthy and unhealthy dietary pattern (HDP and UDP, respectively) were extracted using factor analysis (principal component analysis). Our study revealed a significant higher weight (p = 0.003) and BMI (p = 0.042) in women carrying CC homozygote compared with G allele carriers. Moreover, our findings showed a significant gene-diet interaction between HDP and Cry1 rs2287161 on BMI (p = 0.034) and serum leptin level (p = 0.056) in which, BMI and serum leptin level were lower in subjects with CC genotype than in those with GG genotype while following HDP. This study suggests a significant interaction between Cry1 rs2287161 polymorphisms and HDP on BMI and serum leptin and the lowering effects were apparent among C allele carriers compared to G allele ones. This data highlights the role of dietary pattern in relation of gene and obesity.
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Fatemeh Gholami,Mahsa Samadi,Niloufar Rasaei,Mir Saeid Yekaninejad,Seyed Ali Keshavarz,Gholamali Javdan,Farideh Shiraseb,Niki Bahrampour,Khadijeh Mirzaei 한국임상영양학회 2023 Clinical Nutrition Research Vol.12 No.3
People with higher genetic predisposition to obesity are more susceptible to cardiovascular diseases (CVDs) and healthy plant-based foods may be associated with reduced risks of obesity and other metabolic markers. We investigated whether healthy plant-foods-rich dietary patterns might have inverse associations with cardiometabolic risk factors in participants at genetically elevated risk of obesity. For this cross-sectional study, 377 obese and overweight women were chosen from health centers in Tehran, Iran. We calculated a healthy plant-based diet index (h-PDI) in which healthy plant foods received positive scores, and unhealthy plant and animal foods received reversed scores. A genetic risk score (GRS) was developed based on 3 polymorphisms. The interaction between GRS and h-PDI on cardiometabolic traits was analyzed using a generalized linear model (GLM). We found significant interactions between GRS and h-PDI on body mass index (BMI) (p = 0.02), body fat mass (p = 0.04), and waist circumference (p = 0.056). There were significant gene-diet interactions for healthful plant-derived diets and BMI-GRS on high-sensitivity C-reactive protein (p = 0.03), aspartate aminotransferase (p = 0.04), alanine transaminase (p = 0.05), insulin (p = 0.04), and plasminogen activator inhibitor 1 (p = 0.002). Adherence to h-PDI was more strongly related to decreased levels of the aforementioned markers among participants in the second or top tertile of GRS than those with low GRS. These results highlight that following a plant-based dietary pattern considering genetics appears to be a protective factor against the risks of cardiometabolic abnormalities.
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