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RISS 인기검색어
- 검색키워드
- 저자 : Kenichi Nakanishi (검색결과 3 건)
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Kakino, Kenichi,Kiyohara, Chikako,Horiuchi, Takahiko,Nakanishi, Yoichi Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8
Background: Cytochrome P450 2E1 (CYP2E1) and catechol-O-methyltransferase (COMT) genes may contribute to susceptibility to lung cancer because of their critical involvement in mechanisms of carcinogenesis. Materials and Methods: We evaluated the role of CYP2E1 rs2031920 and COMT rs4680 in a case-control study involving 462 lung cancer cases and 379 controls in Japanese. Logistic regression was used to assess adjusted odds ratios (OR) and 95% confidence intervals (CI). Multiplicative and additive interactions with cigarette smoking or alcohol use were also examined. Results: Neither CYP2E1 rs2031920 nor COMT rs4680 was associated with lung cancer risk overall. However, smokers with the CC genotype of CYP2E1 rs2031920 (OR = 3.57, 95% CI = 2.26 - 5.63) presented a higher risk of lung cancer than those with at least one T allele (OR = 2.91, 95% CI = 1.70 - 4.98) as compared to never-smokers with at least one T allele (reference). Subjects with excessive drinking and the CC genotype of CYP2E1 rs2031920 had a significantly higher risk (OR = 2.22, 95% CI =1.39 - 3.56) than appropriate drinkers with at least one T allele. A similar tendency was observed between COMT rs4680 and either smoking or drinking habits. There were no multiplicative or additive interactions between the polymorphisms and either smoking or alcohol use. Conclusions: Our findings indicate that CYP2E1 rs2031920 and COMT rs4680 are not major contributors to lung cancer risk in our Japanese population. Future studies on the genetics of lung cancer in Japanese and their environment interactions are required.
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Shuntaro Yamato,Kenichi Nakanishi,Norikazu Suzuki,Yasuhiro Kakinuma 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.22 No.2
To maximize the potential for high material removal rates in simultaneous processes such as parallel milling, developing strategies for successful chatter suppression/avoidance is an important concern for manufacturers. In this study, the effectiveness of the spindle speed difference method (SDM) for chatter suppression is discussed in a parallel end-milling process where a flexible workpiece is machined by two tools rotating in opposite direction. The process model is developed, considering that the dynamic variation due to the regenerative eff ect occurs on a plane perpendicular to the tool axis direction. Through the process simulations and the experiments, this study provides informative discussion for comprehending the process behavior. Additionally, a real-time active chatter suppression system with adaptive SDM, where the spindle speed difference is sequentially optimized during the process according to the tracked chatter frequency, is developed by integrating a chatter monitoring system based on sensorless cutting force estimation with sliding discrete Fourier transform. The results show that the developed real-time adaptive system of spindle speed suppresses chatter vibrations more effectively than non-adaptive SDM system; hence, the integrated system can contribute self-optimizing machining systems oriented to Industry 4.0.
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Solar Water Splitting with a Hydrogenase Integrated in Photoelectrochemical Tandem Cells
Nam, Dong Heon,Zhang, Jenny Z.,Andrei, Virgil,Kornienko, Nikolay,Heidary, Nina,Wagner, Andreas,Nakanishi, Kenichi,Sokol, Katarzyna P.,Slater, Barnaby,Zebger, Ingo,Hofmann, Stephan,Fontecilla‐,Ca John Wiley and Sons Inc. 2018 Angewandte Chemie Vol.57 No.33
<P><B>Abstract</B></P><P>Hydrogenases (H<SUB>2</SUB>ases) are benchmark electrocatalysts for H<SUB>2</SUB> production, both in biology and (photo)catalysis in vitro. We report the tailoring of a p‐type Si photocathode for optimal loading and wiring of H<SUB>2</SUB>ase through the introduction of a hierarchical inverse opal (IO) TiO<SUB>2</SUB> interlayer. This proton‐reducing Si|IO‐TiO<SUB>2</SUB>|H<SUB>2</SUB>ase photocathode is capable of driving overall water splitting in combination with a photoanode. We demonstrate unassisted (bias‐free) water splitting by wiring Si|IO‐TiO<SUB>2</SUB>|H<SUB>2</SUB>ase to a modified BiVO<SUB>4</SUB> photoanode in a photoelectrochemical (PEC) cell during several hours of irradiation. Connecting the Si|IO‐TiO<SUB>2</SUB>|H<SUB>2</SUB>ase to a photosystem II (PSII) photoanode provides proof of concept for an engineered Z‐scheme that replaces the non‐complementary, natural light absorber photosystem I with a complementary abiotic silicon photocathode.</P>
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