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RISS 인기검색어
- 검색키워드
- 저자 : Kee-Ching Jeng (검색결과 2 건)
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Chien-Wei Hou,Shun-Yu Chang,Kee-Ching Jeng 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.4
Amyloid beta-protein (Ab) is involved in thepathogenesis of Alzheimer’s disease (AD). Ab induces freeradical production in neuronal cells, leading to oxidativestress and up-regulation of c-Jun N-terminal kinases (JNK),extracellular-signal-regulated kinases (ERK), p38 mitogenactivatedprotein kinase (MAPK) pathways and pro-apoptoticBax expression. Sesamin has been shown to haveprotection to several models of neurodegenerative diseasesby its antioxidant and anti-inflammatory properties. In thepresent study, we examined the neuroprotective effect of asesamin derivative, 3-bis (3-methoxybenzyl) butane-1,4-diol (BBD) on Ab1–42 induced cytotoxicity of PC12 cells. Ab1–42 induced lipid peroxidation, calcium, reactive oxygenspecies from the PC12 cells. The effect of BBD onthese harmful factors and the related signaling pathwayswere examined by biochemical and western blot assays. The result showed that BBD protected PC12 cells fromAb1–42 induced cytotoxicity with the increased cell viabilityand acetylcholine release, and the decreased lactatedehydrogenase, malondialdehyde and calcium release. BBD significantly reduced Ab-induced JNK, ERK, p38MAPK pathways and Bax expression in PC12 cells. Therefore the neuroprotective effect of BBD on Abinducedcytotoxicity was involved with antioxidant andanti-inflammatory effects. The result would help thedevelopment of new CNS drug for protection of AD.
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Effect of Sesamin on Apoptosis and Cell Cycle Arrest in Human Breast Cancer MCF-7 Cells
Siao, An-Ci,Hou, Chien-Wei,Kao, Yung-Hsi,Jeng, Kee-Ching Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Dietary prevention has been known to reduce breast cancer risk. Sesamin is one of the major components in sesame seeds and has been widely studied and proven to have anti-proliferation and anti-angiogenic effects on cancer cells. In this study, the influence of sesamin was tested in the human breast cancer MCF-7 cell line for cell viability (MTT assay) and cell cycling (flow cytometry). Results showed that sesamin dose-dependently (1, 10 and $50{\mu}M$) reduced the cell viability and increased LDH release and apoptosis (TUNEL assay). In addition, there was a significant increase of sub-G1 phase arrest in the cell cycle after sesamin treatment. Furthermore, sesamin increased the expression of apoptotic markers of Bax, caspase-3, and cell cycle control proteins, p53 and checkpoint kinase 2. Taken together, these results suggested that sesamin might be used as a dietary supplement f or prevention of breast cancer by modulating apoptotic signal pathways and inhibiting tumor cell growth.
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