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A Hybrid Genetic Algorithm for the Location-Routing Problem with Simultaneous Pickup and Delivery
Karaoglan, Ismail,Altiparmak, Fulya Korean Institute of Industrial Engineers 2011 Industrial Engineeering & Management Systems Vol.10 No.1
In this paper, we consider the Location-Routing Problem with simultaneous pickup and delivery (LRPSPD) which is a general case of the location-routing problem. The LRPSPD is defined as finding locations of the depots and designing vehicle routes in such a way that pickup and delivery demands of each customer must be performed with same vehicle and the overall cost is minimized. Since the LRPSPD is an NP-hard problem, we propose a hybrid heuristic approach based on genetic algorithms (GA) and simulated annealing (SA) to solve the problem. To evaluate the performance of the proposed approach, we conduct an experimental study and compare its results with those obtained by a branch-and-cut algorithm on a set of instances derived from the literature. Computational results indicate that the proposed hybrid algorithm is able to find optimal or very good quality solutions in a reasonable computation time.
A Hybrid Genetic Algorithm for the Location-Routing Problem with Simultaneous Pickup and Delivery
Ismail Karaoglan,Fulya Altiparmak 대한산업공학회 2011 Industrial Engineeering & Management Systems Vol.10 No.1
In this paper, we consider the Location-Routing Problem with simultaneous pickup and delivery (LRPSPD) which is a general case of the location-routing problem. The LRPSPD is defined as finding locations of the depots and designing vehicle routes in such a way that pickup and delivery demands of each customer must be performed with same vehicle and the overall cost is minimized. Since the LRPSPD is an NP-hard problem, we propose a hybrid heuristic approach based on genetic algorithms (GA) and simulated annealing (SA) to solve the problem. To evaluate the performance of the proposed approach, we conduct an experimental study and compare its results with those obtained by a branch-and-cut algorithm on a set of instances derived from the literature. Computational results indicate that the proposed hybrid algorithm is able to find optimal or very good quality solutions in a reasonable computation time.
The Effects of Difumarate Salt S-15176 after Spinal Cord Injury in Rats
Erdogan, Hakan,Tuncdemir, Matem,Kelten, Bilal,Akdemir, Osman,Karaoglan, Alper,Tasdemiroglu, Erol The Korean Neurosurgical Society 2015 Journal of Korean neurosurgical society Vol.57 No.6
Objective : In the present study we analyzed neuroprotective and antiapoptotic effect of the difumarate salt S-15176, as an anti-ischemic, an antioxidant and a stabilizer of mitochondrial membrane in secondary damage following spinal cord injury (SCI) in a rat model. Methods : Three groups were performed with 30 Wistar rats; control (1), trauma (2), and a trauma+S-15176 (10 mg/kg i.p., dimethyl sulfoxide) treatment (3). SCI was performed at the thoracic level using the weight-drop technique. Spinal cord tissues were collected following intracardiac perfusion in 3rd and 7th days of posttrauma. Hematoxylin and eosin staining for histopatology, terminal deoxynucleotidyl transferase dUTP nick end labeling assay for apoptotic cells and immunohistochemistry for proapoptotic cytochrome-c, Bax and caspase 9 were performed to all groups. Functional recovery test were applied to each group in 3rd and 7th days following SCI. Results : In trauma group, edematous regions, diffuse hemorrhage, necrosis, leukocyte infiltration and severe degeneration in motor neurons were observed prominently in gray matter. The number of apoptotic cells was significantly higher (p<0.05) than control group. In the S-15176-treated groups, apoptotic cell number in 3rd and 7th days (p<0.001), also cytochrome-c (p<0.001), Bax (p<0.001) and caspase 9 immunoreactive cells (p<0.001) were significantly decreased in number compared to trauma groups. Hemorrhage and edema in the focal areas were also noticed in gray matter of treatment groups. Results of the locomotor test were significantly increased in treatment group (p<0.05) when compared to trauma groups. Conclusion : We suggest that difumarate salt S-15176 prevents mitochondrial pathways of apoptosis and protects spinal cord from secondary injury and helps to preserve motor function following SCI in rats.