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Relative Bioavailability Studies on Two Tablet Preparations of Ofloxacin
Shakya, Ashok-K.,Talwar, Naresh,Karajgi, Jayant,Singhai, Akhlesh The Pharmaceutical Society of Korea 1992 Archives of Pharmacal Research Vol.15 No.3
Comparative bioavailability of two tablet dosage forms of ofloxacin (either as Hoechst (India) or Ranbaxy preparation ) was investigated. In a randomized cross-over study, eitht healthy human volunteers received single 200 mg dose of film coated ofloxacin in fasting state. The concentration of ofloxacin in the collected saliva and serum samples were measured by high performance liquid chromatography. No significant difference in bioavailability of both preparations was judged from various serum and seliva pharmacokinetic parameters such as peak concentration, time to peak concentration and are under the curves. Intersubject variation was also found to be insignificant.