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Kang, Min,Yu, Wenjuan,Wang, Zhengyu,Kong, Wubin,Xiao, Ye The Korean Institute of Electrical Engineers 2018 Journal of Electrical Engineering & Technology Vol.13 No.1
This paper investigates optimum air-gap flux distribution with third harmonic rotor flux orientation adjustment for five-phase induction motor. The technique of objective is to generate a nearly rectangular air-gap flux, and it improves iron utilization under variation loading conditions. The proportional relations between third harmonic and fundamental plane currents is usually adopted in the conventional method. However, misalignment between fundamental and third harmonic component occurs with variation loading. The iron of stator teeth is saturated due to this misalignment. This problem is solved by third harmonic rotor flux orientation adjustment simultaneously, and direction and amplitude are changed with mechanical load variation. The proposed method ensures that the air-gap flux density is near rectangular for a maximum value from no load to rated load. It is confirmed that the proposed method guarantees complete both planes decoupling with third harmonic flux orientation adjustment. The effectiveness of the proposed technique is validated experimentally.
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Aglycone specificity of <i>Escherichia coli</i>α‐xylosidase investigated by transxylosylation
Kang, Min‐,Sun,Okuyama, Masayuki,Yaoi, Katsuro,Mitsuishi, Yasushi,Kim, Young‐,Min,Mori, Haruhide,Kim, Doman,Kimura, Atsuo BLACKWELL 2007 FEBS JOURNAL Vol.274 No.23
<P>The specificity of the aglycone‐binding site of <I>Escherichia coli</I>α‐xylosidase (YicI), which belongs to glycoside hydrolase family 31, was characterized by examining the enzyme's transxylosylation‐catalyzing property. Acceptor specificity and regioselectivity were investigated using various sugars as acceptor substrates and α‐xylosyl fluoride as the donor substrate. Comparison of the rate of formation of the glycosyl–enzyme intermediate and the transfer product yield using various acceptor substrates showed that glucose is the best complementary acceptor at the aglycone‐binding site. YicI preferred aldopyranosyl sugars with an equatorial 4‐OH as the acceptor substrate, such as glucose, mannose, and allose, resulting in transfer products. This observation suggests that 4‐OH in the acceptor sugar ring made an essential contribution to transxylosylation catalysis. Fructose was also acceptable in the aglycone‐binding site, producing two regioisomer transfer products. The percentage yields of transxylosylation products from glucose, mannose, fructose, and allose were 57, 44, 27, and 21%, respectively. The disaccharide transfer products formed by YicI, α‐<SMALL>d</SMALL>‐Xyl<I>p</I>‐(1→6)‐<SMALL>d</SMALL>‐Man<I>p</I>, α‐<SMALL>d</SMALL>‐Xyl<I>p</I>‐(1→6)‐<SMALL>d</SMALL>‐Fru<I>f</I>, and α‐<SMALL>d</SMALL>‐Xyl<I>p</I>‐(1→3)‐<SMALL>d</SMALL>‐Fru<I>p</I>, are novel oligosaccharides that have not been reported previously. In the transxylosylation to cello‐oligosaccharides, YicI transferred a xylosyl moiety exclusively to a nonreducing terminal glucose residue by α‐1,6‐xylosidic linkages. Of the transxylosylation products, α‐<SMALL>d</SMALL>‐Xyl<I>p</I>‐(1→6)‐<SMALL>d</SMALL>‐Man<I>p</I> and α‐<SMALL>d</SMALL>‐Xyl<I>p</I>‐(1→6)‐<SMALL>d</SMALL>‐Fru<I>f</I> inhibited intestinal α‐glucosidases.</P>
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Kang, Min,Seo, Hye-Suk,Soh, Sang-Hee,Jang, Hyung-Kwan Elsevier 2018 Veterinary microbiology Vol.222 No.-
<P><B>Abstract</B></P> <P> <I>Riemerella anatipestifer</I> (RA) infections cause major economic losses in the duck industry.</P> <P>In this study, we developed an RA vaccine to control virulent serotype 1 and 2 RA, which predominate in worldwide prevalence. We established a strategy for vaccine candidate screening, and selected strains D15-RDA-92 (serotype 1) and D14-RDA-8 (serotype 2). These strains were characterized by ≤50% embryo mortality and <3.0 serum resistance assay values in <I>in vitro</I> screening. We evaluated the protective efficacy of live bivalent RA vaccines against virulent homologous serotype RA. Ducklings received two oral immunizations with the bivalent vaccine and showed significant protection against two virulent strains (serotypes 1 and 2) at 21 days post-immunization. No death or clinical signs of diarrhea, tremors, or limb swelling were observed in the immunized ducks. In a safety evaluation, ducks immunized with 100 times higher doses showed no clinical signs, mortality, gross lesions, or histological lesions, and body weight of the ducks showed no significant difference compared to that of negative controls. In addition, IgA analysis showed a significant increase in secretory IgA antibodies generated in the trachea and duodenum of orally immunized ducks at 28 days of age. The IgA might be involved in one of the major immune responses to RA and contributes to protecting against virulent RA. In this study, we developed monovalent and bivalent RA vaccines that were safe in ducks and provided significant protective efficacy against virulent homologous RA strains.</P> <P><B>Highlights</B></P> <P> <UL> <LI> <I>Riemerella anatipestifer</I> (RA) causes septicemia in domestic ducks. </LI> <LI> Oral administration of monovalent and bivalent RA vaccines gave significant protection. </LI> <LI> IgA contributes to protecting against virulent RA in live RA vaccine. </LI> </UL> </P>
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Kang Min,Yanyan Sun,Chen-Han Lee,Pengcheng Hu,Shanshan He 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.20 No.11
In computer numerical control machining, tool paths are typically represented with piecewise linear segments (GO1s), which lack G1 and G2 continuity and cause fluctuation of feed rate and acceleration. To improve the continuity of tool paths, some method, e.g., B-spline tool path fitting, is preferred. However, none of the currently B-spline fitting method satisfies all tool-path fitting requirements of arc-length parameterization, G2 continuity and smoothness across the whole path. The aim of this research is to derive an industrial-strength method for B-spline tool path fitting, satisfying all of the named requirements. The improvements cover the arc-length based parameterization, G2 continuity as well as numerically measure to improve the quality of B-spline tool paths. To achieve arc-length parameterization, a preliminary fitting is added to evaluate arc-length and guide the parameterization (i.e., knot vector assignment); for joint G2-continuity, a five-control-point B-spline which satisfies chord error and shape-preserving constraints is constructed to blend adjacent B-splines; and a method based on the Hausdorff distance between the fitted B-splines and the original polylines is used to evaluate the fitting quality, and an additional refinement procedure is employed when the evaluation finds any disqualification. Simulation and experiment results prove that the proposed methods are effective.
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KANG, MIN,WEI, BAI,CHOI, SUNG-WOON,CHA, SE-YEOUN,JANG, HYUNG-KWAN ational Association for Food Protection 2017 Journal of food protection Vol. No.
<P> The purpose of this study was to identify the molecular basis of quinolone resistance of Campylobacter isolates recovered from duck meats. Sixty-one isolates from duck meat samples were studied using sequence analysis of the gyrA gene, and PCR assays were used to identify the presence of the CmeABC efflux pump and its restored sensitivity in the presence of efflux-pump inhibitors. High-level resistance to nalidixic acid and ciprofloxacin was attributed to amino acid substitutions Thr-86-Ile in some isolates. The PCR assay confirmed the presence of the cmeB gene in 29 (47.5%) of the 61 Campylobacter isolates. Phenylalanine arginine b-naphthylamide reduced the MICs of ciprofloxacin and nalidixic acid in 16 (55.2%) and 26 (89.7%) isolates, respectively. The Thr-86-Ile substitution in the gyrA was the primary contributor to the high-level quinolone resistance in Campylobacter isolates from duck meats. </P>
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Kang, Min,Liu, Wen-Qi,Qin, Yu-Tao,Wei, Zhu-Xin,Wang, Ren-Sheng Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Objective: The long-term efficacy of microwave hyperthermia combined with chemoradiotherapy in treating nasopharyngeal carcinoma (NPC) with metastatic foci in cervical lymph nodes was evaluated. Methods: A total of 154 cases of N2 or N3 stage NPC were randomized into two groups: hyperthermia group (76 cases) and control group (78 cases). Both received cisplatin chemotherapy and radiotherapy. In addition, the hyperthermia group further received microwave hyperthermia to the metastatic cervical nodes with different patterns (before or after radiotherapy), heating temperatures (T90< $43^{\circ}C$ and $T90{\geq}43^{\circ}C$) and hyperthermia episodes (< 4 times, 4-10 times and > 10 times). Results: The 3-month and 5-year complete response (CR) rates of cervical lymph nodes in the hyperthermia group were significantly higher than those in the control group. The 5-year disease-free survival (DFS) rate and the 3-year / 5-year overall survival rate in the hyperthermia group were also significantly higher. There was no significant difference in 5-year metastatic rates. In the hyperthermia group, the 3-month and 5-year CR rates of T90< $43^{\circ}C$ treatment were significantly lower than with $T90{\geq}43^{\circ}C$ treatment. The CR rate was highest when the hyperthermia was performed 4-10 times. There were no significant differences in 3-month and 5-year CR rates between hyperthermia before or after radiotherapy treatment. Conclusion: Microwave hyperthermia combined with chemoradiotherapy can increase local control, DFS and 3, 5-year overall survival rates of patients with N2 ~ N3 stage NPC. The heating temperature should be over $43^{\circ}C$ with hyperthermia repeated 4-10 times.
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Kang, Min,Roh, Jae-Hee,Jang, Hyung-Kwan Elsevier 2018 Veterinary microbiology Vol.214 No.-
<P><B>Abstract</B></P> <P>Duck hepatitis A virus (DHAV) infection is characterized by an acute, rapidly spreading that affects young ducklings. DHAV-1 or DHAV-3 infection is prevalent, and simultaneous co-infection with both viruses has recently become increasingly frequent in the domestic duck farms. In this study, we developed a bivalent live attenuated vaccine (DHV-HSBP100 and AP-04203P100) for DHAV-1 and DHAV-3 and reported the protective efficacy and safety of the vaccine. At 1-day-old, the ducklings received a bivalent vaccine via intramuscular injection. The immunized ducklings showed effective and rapid protection against virulent DHAV-1 and DHAV-3 at 2 or 3 days post vaccination. Moreover, the ducklings showed a potent humoral immune response that peaked at 3 weeks and were maintained at 6 weeks after vaccination. The bivalent vaccine was safe; ducklings administered 10 doses of bivalent vaccines showed no clinical signs, mortality, gross lesions, and body weight changes compared with those observed in the negative controls. Ducklings vaccinated with a bivalent vaccine were evaluated for tissue tropism and viral replication of vaccine strains. Both bivalent vaccine strains were detected in various organs, and the highest virus replication was detected in the kidneys, among the tested organs. No interference occurred during the replication of both vaccine strains. Thus, these experiments suggest that bivalent vaccines would be useful as a promising and practical strategy for control DHAV outbreaks caused by DHAV-1 and DHAV-3 in duck farms.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A bivalent vaccine against DHAV-1 and DHAV-3 infection was developed. </LI> <LI> The bivalent vaccine induced complete protection against virulent DHAV-1 or DHAV-3 at 2–3 days after vaccination. </LI> <LI> Ducklings vaccinated with 10 doses did not die and showed no changes in body weight and in clinical or gross lesions. </LI> <LI> The bivalent live attenuated vaccine could contribute to the control of DHAV outbreaks caused by DHAV-1 and −3 in duck farms. </LI> </UL> </P>
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이강민 ( Yi¸ Kang Min ) 현대일본학회 2020 日本硏究論叢 Vol.51 No.-
한국의 일본어연구는 관련 학과의 감소, 연구자의 고령화와 학문 후속세대의 감소 등으로 인한 이중고에 직면하고 있다. 2000년 이후 지속된 연구 논문의 양적 팽창은 2016년부터 감소 추세로 전환되었으며, 2016년을 기점으로 연구자의 고령화 추세가 한층 강화되었다. 연구내용 면에서는 종래의 주류를 차지했던 문법연구가 감소한 반면, 일본어 교육연구의 비중이 증가했다. 그 이유로는 국내 일본인연구자의 논문 증가, 그리고 일본어교육이 가지고 있는 논문 주제 선택 및 접근방법의 편의성과 관련이 있을 것으로 생각된다. 한편, 연구 어젠다에 있어서는 70년대의 일본어 계통론 연구, 80년대의 한국어에 정착된 일본한자어(和製漢語) 연구, 90년대의 조선자료(사역원의 왜학자료)를 활용한 일본어사 연구에서 2000년대 이후 인지언어학, 언어유형론 등의 연구가 간헐적으로 조명을 받았으나, 본격적인 논의가 이어지지 못한 채 현재에 이르고 있다. 이처럼 중심적 연구 어젠다의 부재는 일본어교육을 중심으로 한 연구 주제의 다변화 추세와 밀접한 관련이 있다고 볼 수 있다. 아울러 최근 국제저널(A&HCI, SCOPUS)에 영문논문을 게재하는 국내연구자들의 등장과 중국, 대만, 베트남 등 해외연구자의 국내학술지 논문게재 등은 일본어연구의 새로운 경향으로서 주목된다. Japanese language studies in Korea are facing dual difficulties due to the reduction of related university departments, the aging of researchers, and the decreasing number of young researchers. The expansion of research papers that occurred after 2000 has shown a decreasing trend since 2016 with the concomitant aging of researchers. In terms of research content, a study of Japanese grammar, which occupied the mainstream, has decreased, while the proportion of Japanese language education has increased. This has been attributed to the increasing number of papers by Japanese researchers in Korea. On the other hand, research agendas, such as research on linguistic genealogy in the 1970s, research on Japanese-made Chinese words (和製漢語) in the Korean language in the 1980s, and Japanese history utilizing Korean materials (Japanese language textbooks of Sayeokwon (司譯院)) in the 1990s, and research on cognitive linguistics and linguistic typology have intermittently received academic spotlights, but they did not develop into earnest discussions. The absence of a central research agenda may be related closely to the diversification of research topics centered on Japanese language education. In addition, the recent emergence of Korean researchers who publish English papers in international journals (A&HCI, SCOPUS), and publications in Korean journals by foreign researchers, such as China, Taiwan, and Vietnam, are noted as a new trend in Japanese language studies.
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