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Ultrafine-grained CoCrFeMnNi high-entropy alloy produced by cryogenic multi-pass caliber rolling
Won, Jong Woo,Lee, Sangwon,Park, Sang Hyeop,Kang, Minju,Lim, Ka Ram,Park, Chan Hee,Na, Young Sang Elsevier 2018 JOURNAL OF ALLOYS AND COMPOUNDS Vol.742 No.-
<P><B>Abstract</B></P> <P>The ultrafine-grained (UFG) structure (∼100 nm) of CoCrFeMnNi high-entropy alloy was achieved using cryogenic multi-pass caliber rolling at 77 K to impose less deformation (<I>ε</I> = 1) compared to severe plastic deformation (SPD, <I>ε</I> > 4). Highly increased twinning activity at 77 K caused the grain interiors to fragment significantly, so UFG structure could be induced without imposing SPD. Intersected twin morphology and secondary twins played a key role in twinning-induced grain refinement to achieve UFG structure. The processed material showed an exceptional high yield strength of ∼1.5 GPa with a reasonable fracture elongation of ∼10% at room temperature.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ultrafine grained structure was achieved using cryogenic multi-pass caliber rolling. </LI> <LI> Highly increased twinning activity at 77 K caused grains to fragment significantly. </LI> <LI> Specifically, intersected twins and secondary twins refined grains very effectively. </LI> <LI> So, UFG structure could be achieved without imposing severe plastic deformation. </LI> <LI> The processed material showed an exceptional high yield strength of ∼1.5 GPa. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Kang, Minju,Lim, Ka Ram,Won, Jong Woo,Na, Young Sang Elsevier 2018 JOURNAL OF ALLOYS AND COMPOUNDS Vol.769 No.-
<P><B>Abstract</B></P> <P>The effect of entropy on the strengths of the disordered and ordered phases was investigated. Cost effective AlCo<SUB>x</SUB>CrFeNi (x = 0, 0.25, 0.5, 0.75, and 1) high-entropy alloys were fabricated reducing Co content. The strength was considerably reduced when the Co content was zero. This was attributed to the low hardness of the A2 phase due to reduced configurational entropy compared with quinary system. On the other hand, the ordered B2 phase showed the opposite tendency. This result shows that the configurational entropy causes opposing effects on disordered and ordered phases, and the importance of considering the effect of entropy on each phase when the number of elements changed, and an alloy is composed of two or more phases, in particular, having BCC structure.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Effect of Entropy on the mechanical properties of each phase was studied. </LI> <LI> Considerably lower YS of the AlCrFeNi HEA is due to the low strength of the A2 matrix. </LI> <LI> Configurational entropy causes opposing effects on disordered and ordered phases. </LI> </UL> </P>
BMB Reports : Targeted disruption of EBNA1 in EBV-infected cells attenuated cell growth
( Ka Won Noh ),( Jihyun Park ),( Myung Soo Kang ) 생화학분자생물학회(구 한국생화학분자생물학회) 2016 BMB Reports Vol.49 No.4
Epstein Barr virus (EBV)-encoded nuclear antigen-1 (EBNA1) plays a pivotal in an EBV episome replication and persistence. Despite considerable attempts, there are no EBV drugs or vaccines. We attempted to eradicate EBV episomes by targeting EBNA1 using the transcription activator-like effector nucleases (TALEN) (E1TN). E1TN-mediated transient knockout (KO) of EBNA1 reduced EBNA1 expression, and caused significant loss of EBV genomes and progressive death of EBV-infected cells. Furthermore, when a mixture of EBV-infected Burkitt`s lymphoma (BL) cells and EBV-negative BL cells was targeted by E1TN, EBV-negative cells were counter-selected while most EBV-infected cells died, further substantiating that EBNA1 KO caused selective death of EBV-infected cells. TALEN-mediated transient targeting of EBNA1 attenuated the growth of EBV-infected cells, implicating a possible therapeutic application of E1TN for EBV-associated disorders. [BMB Reports 2016; 49(4): 226-231]
Kang, Woon-Seok,Oh, Chung-Sik,Kwon, Won-Kyoung,Rhee, Ka Young,Lee, Yun Gu,Kim, Tae-Hoon,Lee, Suk Ha,Kim, Seong-Hyop by 2016, the American Society of Anesthesiologists 2016 Anesthesiology Vol.125 No.1
<P>Background: The aim of study was to evaluate the effect of mechanical ventilation mode type, pressure-controlled ventilation (PCV), or volume-controlled ventilation (VCV) on intra-and postoperative surgical bleeding in patients undergoing posterior lumbar interbody fusion (PLIF) surgery. Methods: This was a prospective, randomized, single-blinded, and parallel study that included 56 patients undergoing PLIF and who were mechanically ventilated using PCV or VCV. A permuted block randomization was used with a computer-generated list. The hemodynamic and respiratory parameters were measured after anesthesia induction in supine position, 5 min after patients were changed from supine to prone position, at the time of skin closure, and 5 min after the patients were changed from prone to supine position. The amount of intraoperative surgical bleeding, fluid administration, urine output, and transfusion requirement were measured at the end of surgery. The amount of postoperative bleeding and transfusion requirement were recorded every 24 h for 72 h. Results: The primary outcome was the amount of intraoperative surgical bleeding, and 56 patients were analyzed. The amount of intraoperative surgical bleeding was significantly less in the PCV group than that in the VCV group (median, 253.0 [inter-quartile range, 179.0 to 316.5] ml in PCV group vs. 382.5 [328.0 to 489.5] ml in VCV group; P < 0.001). Comparing other parameters between groups, only peak inspiratory pressure at each measurement point in PCV group was significantly lower than that in VCV group. No harmful events were recorded. Conclusion: Intraoperative PCV decreased intraoperative surgical bleeding in patients undergoing PLIF, which may be related to lower intraoperative peak inspiratory pressure.</P>
( Won Chull Bak ),( Ji Heon Park ),( Young Ae Park ),( Kang Hyeon Ka ) 한국균학회 2014 Mycobiology Vol.42 No.3
Shiitake mushrooms (Lentinula edodes) containing β-glucans may be beneficial for human health; they have been used in the treatment of cancer, hypertension, and high cholesterol levels. The objective of this study was to determine the β-glucan content in different sections of the fruiting bodies and mycelia of ten shiitake mushroom cultivars. The measured β-glucan content ranged from 20.06 ± 1.76% to 44.21 ± 0.13% in the pileus sections, and from 29.74 ± 1.40% to 56.47 ± 4.72% in the stipe sections. The results of this study indicate that the variance in β-glucan content dependent on the shiitake cultivar, and that the β-glucan content is higher in the stipe than in the pileus.