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RISS 인기검색어
- 검색키워드
- 저자 : Kaiguang Zhang (검색결과 4 건)
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Zhang, Yunfeng,Chen, Lele,Cao, Yifan,Chen, Si,Xu, Chao,Xing, Jun,Zhang, Kaiguang The Korean Gastric Cancer Association 2020 Journal of gastric cancer Vol.20 No.2
Purpose: Globally, there is a high incidence of gastric cancer (GC). Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) is reported to play a vital role in several human malignancies. However, there is limited understanding of the role of LETM1 in GC. This study aims to investigate the effects of LETM1 on proliferation, migration, and invasion of GC cells. Materials and Methods: The expression levels of LETM1 in the normal gastric mucosal epithelial cells (GES-1) and GC cells were analyzed by quantitative real-time polymerase chain reaction and western blotting. CCK-8, wound healing, and Transwell invasion assays were performed to evaluate the effect of LETM1 knockdown or overexpression on the proliferation, migration, and invasion of the GC cells, respectively. Additionally, the effect of LETM1 knockdown or overexpression on GC cell apoptosis was determined by flow cytometry. Furthermore, the effect of LETM1 knockdown or overexpression on the expression levels of PI3K/Akt signaling pathway-related proteins was evaluated by western blotting. Results: The GC cells exhibited markedly higher mRNA and protein expression levels of LETM1 than the GES-1 cells. Additionally, the knockdown of LETM1 remarkably suppressed the GC cell proliferation, migration, and invasion, and promoted the apoptosis of GC cells, which were reversed upon LETM1 overexpression. Furthermore, the western blotting analysis indicated that LETM1 facilitates GC progression via the PI3K/Akt signaling pathway. Conclusions: LETM1 acts as an oncogenic gene to promote GC cell proliferation, migration, and invasion via the PI3K/Akt signaling pathway. Therefore, LETM1 may be a potential target for GC diagnosis and treatment.
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AERODYNAMIC CHARACTERISTICS OF MIRA FASTBACK MODEL IN EXPERIMENT AND CFD
Yingchao Zhang,Jintao Zhang,Kaiguang Wu,Zijie Wang,Zhe Zhang 한국자동차공학회 2019 International journal of automotive technology Vol.20 No.4
The lasting high fuel cost has recently inspired the resurgence in drag reduction research for vehicles, which calls for a thorough understanding of the vehicle wake. The acknowledged MIRA fastback vehicle model is characterized by similar real vehicle geometry, thus it is especially suitable for the above purpose. In spite of a considerable number of previous investigations, our knowledge of flow around this model remains incomplete. This paper aims to visit turbulent flow structure behind this model. An investigation has been conducted to measure the near wake flow structure of the MIRA 1/8 scale mode, using both Particle Image Velocimetry (PIV) experimental method and Computational Fluid Dynamics (CFD) simulation method. In order to capture the flow structure accurately, PIV measurement was performed in different sections along three orthogonal directions, and the CFD method acquired additional simulation results to catch the better flow status. Through the maps of the time-averaged vorticity, the instantaneous vorticity and the handled velocity vector from the PIV and CFD methods, we found out the formation mechanism of the transient flow of fastback model and summed up the schematic of flow structure. This study not only analyzed the vortex shedding characteristics of turbulent near wake, but more importantly provided insight into the complex three-dimensional features of the flow structure in the wakes of MIRA fastback model.
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Yunfeng Zhang,Lele Chen,Yifan Cao,Si Chen,Chao Xu,Jun Xing,Kaiguang Zhang 대한위암학회 2020 Journal of gastric cancer Vol.20 No.2
Purpose: Globally, there is a high incidence of gastric cancer (GC). Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) is reported to play a vital role in several human malignancies. However, there is limited understanding of the role of LETM1 in GC. This study aims to investigate the effects of LETM1 on proliferation, migration, and invasion of GC cells. Materials and Methods: The expression levels of LETM1 in the normal gastric mucosal epithelial cells (GES-1) and GC cells were analyzed by quantitative real-time polymerase chain reaction and western blotting. CCK-8, wound healing, and Transwell invasion assays were performed to evaluate the effect of LETM1 knockdown or overexpression on the proliferation, migration, and invasion of the GC cells, respectively. Additionally, the effect of LETM1 knockdown or overexpression on GC cell apoptosis was determined by flow cytometry. Furthermore, the effect of LETM1 knockdown or overexpression on the expression levels of PI3K/Akt signaling pathway-related proteins was evaluated by western blotting. Results: The GC cells exhibited markedly higher mRNA and protein expression levels of LETM1 than the GES-1 cells. Additionally, the knockdown of LETM1 remarkably suppressed the GC cell proliferation, migration, and invasion, and promoted the apoptosis of GC cells, which were reversed upon LETM1 overexpression. Furthermore, the western blotting analysis indicated that LETM1 facilitates GC progression via the PI3K/Akt signaling pathway. Conclusions: LETM1 acts as an oncogenic gene to promote GC cell proliferation, migration, and invasion via the PI3K/Akt signaling pathway. Therefore, LETM1 may be a potential target for GC diagnosis and treatment.
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Kaiguang Luo,Shilei Liu,Hanqing Xiong,Yun Zhang,Charlie Kong,Hailiang Yu 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.11
1 − 6 wt% Al0.5CoCrFeNihigh-entropy alloy particles (HEAp)/AA1050 aluminum matrix composites (AMCs) were preparedby stir casting process. The effect of HEAp mass fractions on microstructure and mechanical properties of the AMCswas studied. The results showed that with the increase in HEAp, the grains were obviously refined, and the ultimate tensilestrength (UTS) was gradually increased. The AA1050 − 3 wt% HEAp AMCs had the optimum mechanical properties. ItsUTS was 115 MPa and its elongation was 32.1%. The fracture mechanism of composites changed from ductile fracture toquasi-cleavage fracture with more HEAp. A theoretical model for predicting the yield strength of composites was established. The theoretical values were in good agreement with experimental results, and the average error between theoreticaland experimental values was 4.2%.
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