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PC-766B' and PC-766B, 16-Membered Macrolide Angiogenesis Inhibitors Produced by Nocardia sp. RK97-56
KO, HACK-RYONG,KAKEYA, HIDEAKI,YOSHIDA, ARIKA,ONOSE, RIE,UEKI, MASASHI,MUROI, MAKOTO,TAKATSUKI, AKIRA,MATSUZAKI, HIROSHI,OSADA, HIROYUKI 한국미생물 · 생명공학회 2002 Journal of microbiology and biotechnology Vol.12 No.5
Angiogenesis is an essential event in a variety of physiological and pathological processes. Therefore, effective inhibition of event is a promising strategy for treating angiogenesis-related diseases, including cancer. The current study investigated two unique bafilomycin-type macrolide inhibitors of angiogenesis, PC-766B' (1) and PC-766B (2). The strain RK97-56 which produced the inhibitors was identified as Nocardia sp. by chemotaxonomic analyses, and the purification of the inhibitors was guided by their anti-angiogenic actives. PC-766B' (1) and PC-766B (2) exhibited potent inhibitory activities towards endothelial cell migration stimulated by the vascular endothelial growth factor(VEGF).