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Recent Molecular and Genetic Findings in Intramedullary Spinal Cord Tumors
Yoshitaka Nagashima,Yusuke Nishimura,Kaoru Eguchi,Junya Yamaguchi,Shoichi Haimoto,Fumiharu Ohka,Masakazu Takayasu,Ryuta Saito 대한척추신경외과학회 2022 Neurospine Vol.19 No.2
The study of genetic alterations and molecular biology in central nervous system (CNS) tumors has improved the accuracy of estimations of patient prognosis and tumor categorization. Therefore, the updated 2021 World Health Organization (WHO) classification includes various diagnostic genes, molecules, and pathways for diagnosis, as well as histological findings. These findings are expected both to have diagnostic applications and to facilitate new targeted therapies that target tumor-specific genetic changes and molecular biology. Intramedullary spinal cord tumors (IMSCTs) are rare CNS tumors that are difficult to treat because they occur in eloquent areas. Although the genetic underpinnings of IMSCTs remain unclear compared to their intracranial counterparts, the genetic characteristics of these tumors are gradually being revealed. Here, we describe the major changes in the new 2021 WHO classification and review the major types of IMSCTs, with an emphasis on their clinical features and genetic alterations.
Jin-Seok Moon,Satoshi Kidokoro,Daisuke Todaka,Sayuri Igusa,Junya Mizoi,Kazuo Shinozaki,Kazuko Yamaguchi-Shinozaki 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07
As one of the most severe stress conditions, drought strongly affects the plant growth and productivity. OsPIL1, a gene encoding a rice Phytochrome Interacting Factor (PIF)-Like transcription factor, was found to be down-regulated under drought stress condition. OsPIL1 shows a diurnal expression pattern and known to be involved in regulation of plant height. However, the mechanisms of down-regulation of OsPIL1 expression under stress conditions are remained unclear. In this study, the expression of PIF4 and PIF5, the most homologous genes of OsPIL1 in Arabidopsis, was analyzed and the expression of these genes were found to be oscillated in circadian manner and down-regulated in response to drought and low temperature similar to that of OsPIL1. To identify the regions involved in the responses to drought, low temperature and diurnal cycle, the promoter analysis of PIF4 was performed using transgenic Arabidopsis. Further promoter analysis is ongoing to specify regulatory regions in more detail.