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RISS 인기검색어
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- 저자 : JungKwan Kim (검색결과 52 건)
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Risk assessment to human health: Consumer exposure to ingredients in air fresheners
Kim, Joo-Hyon,Lee, Daeyeop,Lim, Hyunwoo,Kim, Taksoo,Suk, Kwangsul,Seo, Jungkwan Elsevier 2018 Regulatory toxicology and pharmacology Vol.98 No.-
<P><B>Abstract</B></P> <P>Ingredient chemicals like fragrances may cause adverse health effects. Frequent health risk assessments and stringent management of consumer products are of paramount importance to reduce these serious occurrences. In this study, the respiratory and dermal health effects were assessed in relation to air fresheners. Twenty six fragrance ingredients, thirty four biocidal ingredients, and sixteen hazardous ingredients were analyzed and assessed according to their risk to human health on five groups by application type in eighty two air fresheners. For hazard characterization of ingredients, toxicological information on the intrinsic properties of the ingredients was collected, and reference values were determined as chronic NOAEL. Exposure assessment was performed in two steps. The 95th exposure factor values were used to estimate exposure to assume the worst-case scenario and the maximum concentration determined by the product purpose and application type was used type in tiered 1 assessment. The values input into the exposure algorithms were developed via the exposure route. In the tiered 2 assessment, the 75th exposure factor values were used to estimate the assumed reasonable exposure to ingredients. Six ingredients for the inhalation and twelve ingredients for the dermal route were conducted for tiered 2 assessment. This study showed that the assessed ingredients have no health risks at their maximum concentrations in air fresheners. The approach should be used to establish improved guidelines for specific ingredients that may pose inhalation and dermal hazard.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Twenty six fragrances, thirty four biocides and sixteen hazardous ingredients were identified in eighty two air fresheners. </LI> <LI> Health risk assessments for inhalation and dermal exposure were conducted in two steps, tiered 1and 2. </LI> <LI> Tiered 2 risk assessments were conducted for six ingredients for the inhalation route, and twelve ingredients for the dermal route. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Health risk assessment of dermal and inhalation exposure to deodorants in Korea
Kim, Joo-Hyon,Kim, Taksoo,Yoon, Hyojung,Jo, Areum,Lee, Daeyeop,Kim, Pilje,Seo, Jungkwan Elsevier 2018 The Science of the total environment Vol.625 No.-
<P><B>Abstract</B></P> <P>In Korea, humidifiers that include biocidal ingredients have caused serious lung injuries and deaths. After these incidents, public concern regarding the use of chemicals in products (i.e., chemical phobia) increased. Frequent health risk assessments and stringent management of consumer products are, therefore, of paramount importance to reduce these serious occurrences. In this study, the irritative and respiratory health effects of deodorants were assessed in relation to dermal and inhalation exposure. In total, 64 deodorants were divided into 5 groups by application type, and health risk assessments were conducted on each group. In total, 26 fragrance ingredients and 27 biocidal ingredients were analyzed and assessed according to their risk to human health. Exposure assessment was performed in two steps. In the tiered 1 assessment (screening), the 95th exposure factor values were used to estimate exposure to assume the worst-case scenario. The maximum concentration in the deodorants was used without considering the application type. In the tiered 2 assessment (detail assessment), the 75th exposure factor values were used to estimate the assumed reasonable exposure to ingredients. In these assessments, the maximum concentration used in the exposure models was determined by the product purpose and application type. The values input into the exposure algorithms were developed via the exposure route. Of the selected fragrance and biocidal active ingredients, 18 fragrance and 13 biocidal ingredients were detected in the deodorants that were assessed. From the results of the tiered 1 assessment, it was necessary for tiered 2 risk assessments to be conducted for 6 ingredients for the inhalation route, and 13 ingredients for the dermal route. The inhalation margin of exposure of ingredients in deodorants of gel/trigger/spray types for home/car and fabric/air usage was above the target margin of exposure. The health risk of 6 evaluated ingredients was relatively low for the inhalation route of exposure.</P> <P>This study showed that the assessed ingredients have no health risks at their maximum concentrations in deodorants. The approach discussed in this study should be used to establish improved guidelines for specific ingredients in consumer products, and for setting limits for newly developed raw materials that may pose dermal and inhalation hazard.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Thirteen hazardous ingredients in 482 deodorants were analyzed. </LI> <LI> We assessed irritative and respiratory health effects of sixty four deodorant products. </LI> <LI> Effects on health were assessed for dermal and inhalation exposure in two steps, tiered 1and 2. </LI> <LI> No health risks were noted for maximum concentrations of the deodorant ingredients. </LI> <LI> Health risk assessment approach helps establish guidelines for consumer product ingredients. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Honeybee (<i>Apis cerana</i>) major royal jelly protein 4 exhibits antimicrobial activity
Kim, Bo Yeon,Lee, Kwang Sik,Jung, Boknam,Choi, Yong Soo,Kim, Hye Kyung,Yoon, Hyung Joo,Gui, Zhong-Zheng,Lee, Jungkwan,Jin, Byung Rae 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol. No.
<P><B>Abstract</B></P> <P>Major royal jelly proteins (MRJPs) are important protein components of bee royal jelly (RJ) and exhibit various biological and pharmacological activities. The antimicrobial activities of the royalisin and the jelleines contained within MRJP 1 and MRJP 2 in RJ have been elucidated. However, the antimicrobial effects of other MRJPs remain largely unknown. In this study, we demonstrated the antimicrobial activity of the Asiatic honeybee (<I>Apis cerana</I>) MRJP 4 (AcMRJP4). Recombinant AcMRJP4 was expressed as a 63-kDa protein in baculovirus-infected insect cells. We examined the antimicrobial activity of recombinant AcMRJP4 against bacteria, fungi, and yeast. The mechanisms underlying the antimicrobial activity of AcMRJP4 were assessed using western blot analysis, immunofluorescence staining, and scanning electron microscopy. Recombinant AcMRJP4 bound to the cell walls of bacteria, fungi, and yeast and induced structural damage in the microbial cell walls. AcMRJP4 has an antimicrobial role and exhibits a broad spectrum of antimicrobial activities against bacteria, fungi, and yeast. We demonstrated that AcMRJP4 functions as an antimicrobial agent with activity against bacteria, fungi, and yeast. Together, our data identified a novel function of MRJP 4 as an antimicrobial agent.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The cDNA of the honeybee (<I>Apis cerana</I>) major royal jelly protein 4 (AcMRJP4) was cloned. </LI> <LI> AcMRJP4 exhibits antimicrobial activities against bacteria, fungi, and yeast. </LI> <LI> AcMRJP4 functions as an antimicrobial agent. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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김정관(Kim, JungKwan) 국제언어문학회 2016 國際言語文學 Vol.- No.35
본고는 최인훈의 예술관과 역사 철학적 사유가 텍스트 생성 양식과 미적 구성 형식을 통해 본격적으로 구현된 작품으로 『서유기』를 선택하고, 텍스트 생성 원리인 ‘고고학적탐구 방법’과 ‘알레고리적 기호 형식’의 기능과 의미를 밝혀서 이 작품의 문학사적 위상과 가치를 재고하려는 목적으로 진행되었다. 『서유기』는 로만스(romance) 양식의 탐구적 환몽 구조를 바탕으로 개인과 역사의 심처에 파묻힌 정신사적 원체험의 의미를 알레고리적 형식 기법을 통하여 극단적으로 천착해 들어간 반리얼리즘 소설이다. 소설의 서사를 추동하는 ‘고고학적 탐구’의 의미기능은 개인의 심층에 묻혀 있는 역사적 과거의 왜곡된 의미상을 발굴하고, 또한 이 작업의 끝에서 발견된 "원초적 경험"의 이미지를 민족의 집단 무의식적 소망으로 재신화화하여 훼손된 역사와 삶을 회복시키려는 상징적 소설 미학을 포괄한다. 이처럼 개인적 층위와 역사적 층위, 과거의 시대와 현재의 시대의 변증법적 교호 작용을 통해 알레고리적으로 이끌어낸 인간과 역사적 삶에 대한 새로운 인식 지평이야말로 『서유기』의 고고학적 상상력이 성취해낸 현대 소설적 가치가 될 것이다. This thesis proposes on reconsidering the status and value of Choi In-hoon"s novel 「Seoyougee」 withinhistory of literature by enunciating the function and meaning of "the archaeological researching narration" and "the allegory form" in this work. 「Seoyougee」 is the anti-realistic novel which digs into the intellectual historical meaning through the allegorical form-technique, which is buried under deep place of the individual and history based on the enquiring wreathen-dream structure of the romance style. The meaning and function of the archaeological research that drives the narration of the novel excavate the distorted meaning shape which is laid under the individual"s deep layer, remythologize the image of the basic experience that is discovered at the end point of this work with people"s group unconscious wish, and embrace the symbolic fiction esthetics which intends to recover the multilated history and life. The new perceptional prospect on the human and historic life that is extracted allegorically through the dialectic reciprocal action between individual dimension and historical dimension and the bygone ages and modern times, will be guaranteed to be the worth of the modern novel which the archaeological imagination of the 「Seoyougee」 has accomplished.
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Lee, Jungkwan,Myong, Kilseon,Kim, Jung-Eun,Kim, Hee-Kyoung,Yun, Sung-Hwan,Lee, Yin-Won Microbiology Society 2012 Microbiology Vol.158 No.7
<P>The velvet genes are conserved in ascomycetous fungi and function as global regulators of differentiation and secondary metabolism. Here, we characterized one of the velvet genes, designated FgVelB, in the plant-pathogenic fungus Fusarium graminearum, which causes fusarium head blight in cereals and produces mycotoxins within plants. FgVelB-deleted (δFgVelB) strains produced fewer aerial mycelia with less pigmentation than those of the wild-type (WT) during vegetative growth. Under sexual development conditions, the δFgVelB strains produced no fruiting bodies but retained male fertility, and conidiation was threefold higher compared with the WT strain. Production of trichothecene and zearalenone was dramatically reduced compared with the WT strain. In addition, the δFgVelB strains were incapable of colonizing host plant tissues. Transcript analyses revealed that FgVelB was highly expressed during the sexual development stage, and may be regulated by a mitogen-activated protein kinase cascade. Microarray analysis showed that FgVelB affects regulatory pathways mediated by the mating-type loci and a G-protein alpha subunit, as well as primary and secondary metabolism. These results suggest that FgVelB has diverse biological functions, probably by acting as a member of a possible velvet protein complex, although identification of the FgVelB-FgVeA complex and the determination of its roles require further investigation.</P>
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