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Inactivated Sendai Virus Strain Tianjin Induces Apoptosis in Human Breast Cancer MDA-MB-231 Cells
Chen, Jun,Han, Han,Chen, Min,Xu, Xiao-Zhu,Wang, Bin,Shi, Li-Ying Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.12
Sendai virus strain Tianjin is a novel genotype. Here, we investigate the antitumor and proapoptotic effects of ultraviolet-inactivated Sendai virus strain Tianjin (UV-Tianjin) on human breast cancer MDA-MB-231 cells in vitro, as well as the involvement of the apoptotic pathway in the mechanism of UV-Tianjin-induced antitumor effects. MTT assays showed that treatment with UV-Tianjin dose-dependently inhibited the proliferation of MDA-MB-231 cells but not normal MCF 10A breast epithelium cells. Hoechst staining and flow cytometric analysis revealed that UV-Tianjin induced apoptosis of MDA-MB-231 cells in a dose-dependent manner. Moreover, UV-Tianjin treatment resulted in reduction in the mitochondria membrane potential (MMP) and release of cytochrome complex (cyt c) via regulation of Bax and Bcl-2, as well as activation of caspase-9, caspase-3, Fas, FasL and caspase-8 in MDA-MB-231 cells. In summary, our study suggests that UV-Tianjin exhibits anticancer activity in human breast cancer MDA-MB-231 cells through inducing apoptosis, which may involve both the endogenous mitochondrial and exogenous death receptor pathways.
Correlations Between Serum IL33 and Tumor Development: a Meta-analysis
Chen, Xiang-Jun,Huang, Ying-De,Li, Nian,Chen, Min,Liu, Fang,Pu, Dan,Zhou, Tao-You Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8
Background: Interleukin-33 (IL-33) has recently been implicated in tumor development. Methods: Data was obtained from PubMed, EMBASE, Clinical trial, Cochrane Library, Web of Science, CNKI and Wanfang databases. After quality assessment and data extraction, a meta-analysis was performed using Review Manager 5.2 software. Results: There were eight documents included in this meta-analysis. The results showed IL33 levels to be higher in tumor patients than that in health people, but no correlations tumor stage, metastasis and survival time of tumor patients were evident. Conclusion: IL33 may be useful as an alarm factor in tumor detection and prognosis.
STRONG CONVERGENCE OF EXTENDED GENERAL VARIATIONAL INEQUALITIES AND NONEXPANSIVE MAPPINGS
Jun-Min Chen,Li-Juan Zhang,Zhen He 영남수학회 2010 East Asian mathematical journal Vol.26 No.1
In this paper, we suggest and analyze some three step iterative scheme for finding the common elements of the set of the solutions of the extended general variational inequalities involving three operators and the set of the fixed points of nonexpansive mappings. We also consider the convergence analysis of suggested iterative schemes under some mild conditions. Since the extended general variational inequalities include general variational inequalities and several other classes of variational inequalities as special cases, results obtained in this paper continue to hold for these problems. Results obtained in this paper may be viewed as a refinement and improvement of the previously known results.
Viscosity methods of approximation for a common solution of a finite family of accretive operators
Jun-Min Chen,Li-Juan Zhang,Tie-Gang Fan 영남수학회 2011 East Asian mathematical journal Vol.27 No.1
In this paper, we try to extend the viscosity approximation technique to find a particular common zero of a finite family of accretive mappings in a Banach space which is strictly convex reflexive and has a weakly sequentially continuous duality mapping. The explicit viscosity approximation scheme is proposed and its strong convergence to a solution of a variational inequality is proved.
GENERALIZED SYSTEM FOR RELAXED COCOERCIVE EXTENDED GENERAL VARIATIONAL INEQUALITIES
Jun-Min, Chen,Hui, Tong The Youngnam Mathematical Society 2012 East Asian mathematical journal Vol.28 No.5
The approximate solvability of a generalized system for relaxed cocoercive extended general variational inequalities is studied by using the project operator technique. The results presented in this paper are more general and include many previously known results as special cases.
Factors for Postoperative Gallstone Occurrence in Patients with Gastric Cancer: a Meta-analysis
Chen, Xiang-Jun,Li, Nian,Huang, Ying-De,Ren, Shuang,Liu, Fang,Chen, Lian,Wang, Yong,Chen, Min Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2
Objective: To evaluate risk factors for gallstones after gastrectomy. Methods: To identify documents published from 1990 to 2011 the Pubmed, Cochrane Library, Springer Link, CBM and WanFang databases were searched and a meta-analysis was performed with RevMan 5.2 software for odds ratios and 95%CIs. Results: Fifteen studies were selected for the meta-analysis. The pooled ORs [95%CIs] were 0.56 [0.43, 0.73], (P<0.0001) for digestive tract reconstruction, 0.80 [0.54, 1.17], (P=0.25) for pylorus preservation, 0.33[0.15, 0.75], (P=0.008) for resection scope of stomach, 0.33 [0.15, 0.75], (P=0.008) for lymphadenectomy, and 0.13 [0.05, 0.33], (P<0.0001) for vagotomy. Conclusions: Digestive tract physical reconstruction and vagus nerve preservation can reduce the morbidity of gallstones after gastrectomy. Total gastrectomy can add to the morbidity of galltones as does increasing the degree of lymph node dissection. There was no significant difference in gallstones with or without pylorus preservation.
Generalized system for relaxed cocoercive extended general variational inequalities
Chen Jun-Min,Tong Hui 영남수학회 2012 East Asian mathematical journal Vol.28 No.5
The approximate solvability of a generalized system for re- laxed cocoercive extended general variational inequalities is studied by using the project operator technique. The results presented in this paper are more general and include many previously known results as special cases.
Meta Analysis of Association of the IL-17F rs763780T>C Gene Polymorphism with Cancer Risk
Chen, Xiang-Jun,Zhou, Tao-You,Chen, Min,Pu, Dan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19
Purpose: To investigate the association of IL-17F rs763780T>C with cancer risk. Materials and Methods: We searched the Cochrane Central Library, PubMed, MEDLINE, EMBASE, CNKI (China National Knowledge Infrastructure) and WangFang databases until May 2014 for a meta-analysis conducted using RevMan 5.2 software. Results: A total of ten papers were included into this meta analysis, involving 3, 336 cases and 4, 217 healthy people. There were no significant differences on association of IL-17F rs763780T>C polymorphism with cancer risk except in the CC vs TT genetic model. Although the the risk in the gastric cancer group is higher than that in control group, there were no significant differences on the association of IL-17F rs763780T>C polymorphism with other cancers. Conclusions: Our meta analysis reveal the IL-17A rs763780T>C gene polymorphism is involved in risk of gastric cancer but not other tumor types.
STRONG CONVERGENCE OF EXTENDED GENERAL VARIATIONAL INEQUALITIES AND NONEXPANSIVE MAPPINGS
Chen, Jun-Min,Zhang, Li-Juan,He, Zhen The Youngnam Mathematical Society 2010 East Asian mathematical journal Vol.26 No.1
In this paper, we suggest and analyze some three step iterative scheme for finding the common elements of the set of the solutions of the extended general variational inequalities involving three operators and the set of the fixed points of nonexpansive mappings. We also consider the convergence analysis of suggested iterative schemes under some mild conditions. Since the extended general variational inequalities include general variational inequalities and several other classes of variational inequalities as special cases, results obtained in this paper continue to hold for these problems. Results obtained in this paper may be viewed as a refinement and improvement of the previously known results.
Chen, Xiang-Jun,Zhou, Tao-You,Chen, Min,Li, Nian,Liu, Fang Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9
Objective: To investigate any association of the miRNA146a rs2910164 C>G polymorphism with head and neck cancer risk. Materials and Methods: The Medline, PubMed, PUBMED, EMBASE, Web of Science, WanFang and CNKI databases were searched and a meta-analysis was conducted using RevMan 5.2 software. Results: After searching and evaluating the literature, a total seven papers involving 2,766 patients with head and neck cancer and 6,603 healthy controls were included into this meta analysis. The results showed that there were no significant differences between patients and healthy controls overall for the miRNA rs2910164 C>G gene polymorphism (dominant model:OR=0.78, 95%CI:0.58-1.04, P=0.09; recessive model:OR=0.86, 95%CI:0.67-1.12, P=0.27;GG:CC:OR=0.75, 95%CI:0.52-1.08, P=0.12;GC:CC:OR=0.79, 95%CI:0.60-1.04, P=0.10). However, a significant association of miRNA rs2910164 C>G gene polymorphism with Chinese head and neck cancer risk was noted, limited to the dominant model (OR=0.68, 95%CI:0.50-0.95, P=0.02;GG:CC:OR=0.62, 95%CI:0.42-0.92, P=0.02;GC:CC:OR=0.72, 95%CI:0.520.99, P=0.04). Conclusions: miRNA146a rs2910164 C>G polymorphism is not associated with head and neck cancer risk in general, but tehre may be link in Chinese.