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RISS 인기검색어
- 검색키워드
- 저자 : José Salazar (검색결과 4 건)
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Treatment of autoimmune hemolytic anemia: real world data from a reference center in Mexico
José Carlos Jaime-Pérez,Patrizia Aguilar-Calderón,Lorena Salazar-Cavazos,Andrés Gómez-De León,David Gómez-Almaguer 대한혈액학회 2019 Blood Research Vol.54 No.2
BackgroundWarm autoimmune hemolytic anemia (w-AIHA) is an uncommon disease with heteroge-neous response to treatment. Steroids are the standard treatment at diagnosis, whereas rituximab has recently been recommended as the second-line therapy of choice. Our main objective was to document the response to treatment in patients with newly diag-nosed w-AIHA, including the effectiveness of low-dose rituximab as frontline treatment and for refractory disease.MethodsPatients with w-AIHA from 2002 to 2017 were included. Relapse-free survival (RFS), prob-ability of maintained response (MR), and time-to-response were analyzed using the Kaplan‒Meier method. Response was classified as complete, partial, and no response.ResultsWe included 64 adults with w-AIHA (39 women and 25 men). The median age was 37 (16‒77) years. Response rates to steroids alone were 76.7%, rituximab plus steroids, 100%; and cyclophosphamide, 80%. RFS with steroids at 6, 36, and 72 months was 86.3%, 65.1%, and 59.7%, respectively. Eighteen patients received rituximab at 100 mg/wk for 4 weeks plus high-dose dexamethasone as first-line therapy, with RFS at 6, 36, and 72 months of 92.3%, 58.7% and 44.1%, respectively. Eight patients refractory to several lines of therapy were treated with low-dose rituximab, and all achieved a response (three com-plete response and five partial response) at a median 16 days (95% confidence interval, 14.1‒17.8), with a 75% probability of MR at 103 months; the mean MR was 81.93±18months.ConclusionOutcomes of w-AIHA treatment were considerably heterogeneous. Low rituximab doses plus high dexamethasone doses were effective for refractory disease.
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Seismic response estimation of steel buildings with deep columns and PMRF
Alfredo Reyes-Salazar,Manuel E. Soto-López,José R. Gaxiola-Camacho,Edén Bojórquez,Arturo Lopez-Barraza 국제구조공학회 2014 Steel and Composite Structures, An International J Vol.17 No.4
The responses of steel buildings with perimeter moment resisting frames (PMRF) with medium size columns (W14) are estimated and compared with those of buildings with deep columns (W27), which are selected according to two criteria: equivalent resistance and equivalent weight. It is shown that buildings with W27 columns have no problems of lateral torsional, local or shear buckling in panel zone. Whether the response is larger for W14 or W27 columns, depends on the level of deformation, the response parameter and the structural modeling under consideration. Modeling buildings as two-dimensional structures result in an overestimation of the response. For multiple response parameters, the W14 columns produce larger responses for elastic behavior. The axial load on columns may be significantly larger for the buildings with W14 columns. The interstory displacements are always larger for W14 columns, particularly for equivalent weight and plane models, implying that using deep columns helps to reduce interstory displacements. This is particularly important for tall buildings where the design is usually controlled by the drift limit state. The interstory shears in interior gravity frames (GF) are significantly reduced when deep columns are used. This helps to counteract the no conservative effect that results in design practice, when lateral seismic loads are not considered in GF of steel buildings with PMRF. Thus, the behavior of steel buildings with deep columns, in general, may be superior to that of buildings with medium columns, using less weight and representing, therefore, a lower cost.
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Combined effect of the horizontal components of earthquakes for moment resisting steel frames
Alfredo Reyes-Salazar,José A. Juárez-Duarte,Arturo López-Barraza,Juan I. Velázquez-Dimas 국제구조공학회 2004 Steel and Composite Structures, An International J Vol.4 No.3
The commonly used seismic design procedures to evaluate the maximum effect of both horizontal components of earthquakes, namely, the Square Root of the Sum of the Squares (SRSS) and the 30- percent (30%) combination rules, are re-evaluated. The maximum seismic responses of four threedimensional moment resisting steel frames, in terms of the total base shear and the axial loads at interior, lateral and corner columns, are estimated as realistically as possible by simultaneously applying both horizontal components. Then, the abovementioned combination rules and others are evaluated. The numerical study indicates that both, the SRSS rule and the 30% combination method, may underestimate the combined effect. It is observed that the underestimation is more for the SRSS than for the 30% rule. In addition, the underestimation is more for inelastic analysis than for elastic analysis. The underestimation cannot be correlated with the height of the frames or the predominant period of the earthquakes. A basic probabilistic study is performed in order to estimate the accuracy of the 30% rule in the evaluation of the combined effect. Based on the results obtained in this study, it is concluded that the design requirements for the combined effect of the horizontal components, as outlined in some code-specified seismic design procedures, need to be modified. New combination ways are suggested.
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