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RISS 인기검색어
- 검색키워드
- 저자 : Jordi Puiggalí (검색결과 4 건)
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Elena Llorens,Luis J. del Valle,Jordi Puiggalí 한국고분자학회 2014 Macromolecular Research Vol.22 No.4
Polylactide (PLA) nanofibers loaded with antioxidants, i.e. vitamin B6 or pyridoxine (PN) and its analoguepyridoxal (PL), and with hydroxycinnamic acids, i.e. p-coumaric acid (CUM) and caffeic acid (CAF), wereprepared by the electrospinning technique. The control consisted of nanofibers loaded with trolox (TRX). Experimentally,these new materials were tested on the inhibition of oxidative DNA damage caused by free radicals initiatedby 2,2'-azobis (2-amidinopropane hydrochloride) (AAPH). This damage was assessed in vitro and in vivo bymeasuring the conversion of supercoiled pUC19 plasmid DNA to open circular and linear forms. It was found thatthese antioxidants, in solution, could significantly inhibit oxidative DNA damage, and that the antioxidants loadedin the PLA nanofibers maintained in vitro and in vivo their protective role against oxidative DNA damage. Thus,electrospun mats derived from PLA nanofibers loaded with the considered compounds have the capacity to protectDNA against oxidative damage, and appear interesting, for their use in the purification of plasmidic or genomic DNA.
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Elena Llorens,Luis J. del Valle,Jordi Puiggalí 한국고분자학회 2015 Macromolecular Research Vol.23 No.7
Polylactide (PLA) electrospun microfibers were prepared and loaded with triclosan (TCS), ketoprofen (KTP), or their combination to obtain multifunctional scaffolds with bactericide and anti-inflammatory properties. Continuous and porous fibers with diameters in the micrometer scale and a unimodal distribution were successfully attained using a dual-electrospinning technique. Dual drug-loaded scaffolds showed a peculiar release that was in contrast to the single drug-loaded systems, which suggested the establishment of intermolecular interactions that delayed TCS and KTP release. Antimicrobial activity of all TCS-loaded electrospun scaffolds was demonstrated against E. coli and M. luteus bacteria; and furthermore, KTP-loaded samples slightly showed bactericide activity. Biocompatibility of scaffolds was evaluated by adhesion and proliferation assays, and interestingly, the dual drug-load systems were able to support high TCS doses without adverse effects.
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Nina Heidarzadeh,Luis J. del Valle,Lourdes Franco,Jordi Puiggalí 한국고분자학회 2020 Macromolecular Research Vol.28 No.1
Incorporation of aliphatic units to poly(butylene terephthalate) (PBT) gives rise to biodegradable copolymers with tunable properties (e.g., degradability), depending on the selected comonomer and the specific composition. Specifically, a low molecular weight poly(butylene sebacate-co-terephthalate) (PBSeT) with a high ratio of aliphatic sebacate units (i.e., 70 mol-% with respect to the total dicarboxylate content) has been employed in this work to get new electrospun biodegradable scaffolds. Appropriate electrospinning conditions have been found despite the limited copolymer molecular weight. In addition, PBSeT has been employed to improve biocompatibility and biodegradability of scaffolds based on the PBT homopolymer. Scaffolds with different properties have been prepared following two strategies: Electrospinning of single solutions of PBT and PBSeT mixtures and co-electrospinning of independent PBT and PBSeT solutions. Characterization involved spectroscopic (FTIR, NMR), calorimetric (DSC, TGA) and surface hydrophobicity analyses. Hydrolytic and enzymatic degradation studies demonstrated the success of the approach due to the susceptibility of the PBSeT component towards the enzymatic attack with lipases from Pseudomonas cepacia and even towards high temperature hydrolysis.
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Elena Llorens,Luis J. del Valle,Angélica Díaz,María T. Casas,Jordi Puiggalí 한국고분자학회 2013 Macromolecular Research Vol.21 No.7
Electrospun polylactide nanofibers loaded with different antioxidants (i.e. vitamin B6 in pyridoxine and pyridoxal form, p-coumaric acid and caffeic acid) are prepared from N,N-dimethylformamide/dimethylsulfoxide solutions. Morphology, structure and crystallinity of the nanofibers are evaluated by transmission electron microscope (TEM), scanning electron microscope (SEM), X-ray diffraction and differential scanning calorimetry (DSC)techniques. Fibers are highly amorphous but able to crystallize easily due to the high molecular orientation induced by the electrospinning process. The drug molecules are incorporated into the polymeric matrix or formed isolated crystals. A fast release of loaded drug occurs within the first 8 h in hydrophobic medium; but, a slow and sustained release during several days occurs in a hydrophilic medium. Cell attachment on the loaded scaffolds was unaffected by the incorporation of the antioxidants. In contrast, cell proliferation increases with high antioxidative activity against free radicals responsible for cell damage. These new electrospun scaffolds provide high protection of cells against oxidative stress and resulting in innovative 3D fibrous platforms for tissue growth and proliferation.
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