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토양 수분함량 변화에 따른 용적전기전도도 변화와 포화침출액전기전도도의 상관관계
백누리(Nuri Baek),서보성(Bo-Seong Seo),정영재(Young-Jae Jeong),이승민(Seung-Min Lee),김한중(Han-Joong Kim),오효림(Hyo-Lim, Oh),최현수(Hyeon-Su Choi),박서우(Seo-Woo Park),허수빈(Su-Bin Seo),신은서(Eun-Seo Sin),최우정(Woo-Jung Choi) 한국토양비료학회 2021 한국토양비료학회 학술발표회 초록집 Vol.2021 No.11
간척농지 염농도 관리를 위해서 염농도 자동계측기 설치가 확대되고 있다. 자동계측기에서는 용적전기 전도도(Bulk electrical conductivity, EC<SUB>b</SUB>)가 측정되는데, EC<SUB>b</SUB>는 토양 수분에 크게 영향을 받는다. 따라서, EC<SUB>b</SUB>를 토양 수분함량에 독립적인 포화침출액 전기전도도(Saturated-paste extract EC, EC<SUB>e</SUB>)로 환산할 필요가 있다. 본 연구에서는, 실내 토조실험을 통해 사양토와 미사질 양토를 이용하여 EC<SUB>b</SUB>와 EC<SUB>e</SUB>의 상관관계를 구명하였다. 토조에 세 가지 수준의 염농도로 조정된 토양을 충진하고 염농도 센서(Teros12)를 설치한 후 수분을 과포화 상태로 조정하여 각각의 토양에 대해 약 2주간 실험을 수행하였다. 사양토의 EC<SUB>e</SUB>는 4.5, 7.0, 10.5 dS m<SUP>-1</SUP> 였고, 미사질양토의 EC<SUB>e</SUB>는 4.3, 7.8, 11.4 dS m<SUP>-1</SUP> 였다. 시간이 경과함에 따라 토양 수분 함량은 증발에 의해 약 0.2 cm³ cm<SUP>-3</SUP>로 감소하였다. 수분 함량이 과포화에서 약 0.3 cm³ cm<SUP>-3</SUP> 수준으로 감소하는 동안 EC<SUB>b</SUB>는 염 농축에 의해 증가하였지만, 그 이후부터는 수분 함량이 감소함에 따라 이온 활동도가 감소하여 EC<SUB>b</SUB>도 감소하였다. EC<SUB>b</SUB>가 EC<SUB>e</SUB>에 가장 근접하게 측정되는 수분함량은 토양 염농도 수분별로 상이하였는데, 사양토의 경우 ECe는 4.5, 7.0, 10.5 dS m<SUP>-1</SUP>에서 각각 0.39, 0.39, 0.28 cm³ cm<SUP>-3</SUP> 였고, 미사질양토의 경우에는 ECe는 4.3, 7.8, 11.4 dS m<SUP>-1</SUP>에서 각각 0.48, 0.62, 0.50 cm³ cm<SUP>-3</SUP> 였다. 해당 수분 함량에서 EC<SUB>b</SUB>와 EC<SUB>e</SUB>는 매우 강한 상관관계를 보였는데, 회귀식은 사양토와 미사질양토가 각각 EC<SUB>b</SUB>=EC<SUB>e</SUB> 0.80 x + 1.3, EC<SUB>b</SUB>=EC<SUB>e</SUB> –0.27 x² + 4.7 x - 9.8 였다. 본 연구결과는 염농도 자동계측기에서 측정하는 EC<SUB>b</SUB>가 토양 수분함량이 높을 때는 염농도 희석, 그리고 수분함량이 낮을 때는 이온 활동도 감소에 의해 크게 변하는 것을 보여준다. 따라서, EC<SUB>b</SUB>가 EC<SUB>e</SUB>와 유사한 토양 수분 함량 조건에서만 EC<SUB>b</SUB>를 직접 활용할 수 있는 것으로 나타났다. 따라서, 향후 염농도 자동계측기의 활용도를 높이기 위해서는 토양수분함량에 따른 EC<SUB>b</SUB> 변화를 정량화하여 토양수분함량의 영향을 제거할 수 있는 방법 개발이 필요하다.
Seo, Bo Am,Cho, Taesup,Lee, Daniel Z.,Lee, Joong-jae,Lee, Boyoung,Kim, Seong-Wook,Shin, Hee-Sup,Kang, Myoung-Goo National Academy of Sciences 2018 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.115 No.27
<P>Mutations in the human LARGE gene result in severe intellectual disability and muscular dystrophy. How LARGE mutation leads to intellectual disability, however, is unclear. In our proteomic study, LARGE was found to be a component of the AMPA-type glutamate receptor (AMPA-R) protein complex, a main player for learning and memory in the brain. Here, our functional study of LARGE showed that LARGE at the Golgi apparatus (Golgi) negatively controlled AMPA-R trafficking from the Golgi to the plasma membrane, leading to down-regulated surface and synaptic AMPA-R targeting. In LARGE knockdown mice, long-term potentiation (LTP) was occluded by synaptic AMPA-R overloading, resulting in impaired contextual fear memory. These findings indicate that the fine-tuning of AMPAR trafficking by LARGE at the Golgi is critical for hippocampus-dependent memory in the brain. Our study thus provides insights into the pathophysiology underlying cognitive deficits in brain disorders associated with intellectual disability.</P>
김보중 ( Bo Joong Kim ),박영옥 ( Young Ok Park ),서영준 ( Young June Seo ),이증훈 ( Jeung Hoon Lee ),박장규 ( Jang Kyu Park ) 대한피부과학회 2006 대한피부과학회지 Vol.44 No.9
Background: Androgenetic alopecia (AGA) occurs as a result of progressive miniaturization of scalp hair in genetically predisposed individuals. Several effective treatments for AGA are well known. However, there is a paucity of literature about the influence of such treatments on the frontal hair line (FHL). Objective: To assess the effectiveness of oral finasteride and/or topical minoxidil on the FHL. Methods: An assessment of 100 male patients with AGA of grades II to IV was made, based on the Norwood-Hamilton scale after six months of treatment. The patients were divided into three groups. Group 1 received 1 ㎎ of oral finasteride daily. Group 2 exclusively used 5% minoxidil solution 1 ml twice daily. Group 3 received 1 ㎎ of finasteride daily in combination with a topical application of 5% minoxidil solution. We measured the length from the mid-pupillary line to three points of the FHL with calipers; midpoint of the forehead, and right and left temporal recession, respectively. Results: An improvement of the FHL was observed in all of three groups. There was a tendency for patients taking only finasteride to show an overall improvement in the frontal hair line, while patients applying only minoxidil solution showed an improvement in both temporal recession lines. Comparing the three groups at three points of the FHL respectively, at both temporal recession of the FHL, Group 3 showed the best result, followed by Group 2, and finally Group 1. The center of the FHL Group 3 showed the best result, followed by Group 1, and finally Group 2. Conclusion: We found that the combination therapy of finasteride and minoxidil had a synergic effect on FHL in the treatment of androgenetic alopecia. In the assessment of treatment efficacy to the FHL of patients with AGA, the method of using calipers in this study was worthwhile. (Korean J Dermatol 2006;44(9):1065~1071)
김보중 ( Bo Joong Kim ),전은경 ( Eun Kyung Jeon ),서영준 ( Young June Seo ),이증훈 ( Jeung Hoon Lee ),박장규 ( Jang Kyu Park ) 대한피부과학회 2006 대한피부과학회지 Vol.44 No.12
Cutaneous metastases of internal malignancies are rare and the incidence of metastatic skin lesions as the first symptom of disease is only 0.8% in patients of all malignancies. Furthermore, cutaneous metastasis from adenocarcinoma of the stomach has been found to be exceedingly rare. A 39-year-old woman presented with multiple, asymptomatic, erythematous nodules on her scalp and back. A biopsy taken from the nodule showed a signet ring cell type of adenocarcinoma. A gastroendoscopic examination and biopsy was done and showed the same histologic findings. The diagnosis of cutaneous metastasis of signet-ring cell gastric carcinoma was made. It is clinically worth reporting that the first symptom was skin lesions of the scalp and back. (Korean J Dermatol 2006;44(12):1426~1429)