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Psychosis in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study
Hanly, John G.,Li, Qiuju,Su, Li,Urowitz, Murray B.,Gordon, Caroline,Bae, Sang‐,Cheol,Romero‐,Diaz, Juanita,Sanchez‐,Guerrero, Jorge,Bernatsky, Sasha,Clarke, Ann E.,Wallace, Daniel J. Wiley (John WileySons) 2019 Arthritis & rheumatology Vol.71 No.2
Lertratanakul, Apinya,Wu, Peggy,Dyer, Alan,Urowitz, Murray,Gladman, Dafna,Fortin, Paul,Bae, Sang-Cheol,Gordon, Caroline,Clarke, Ann,Bernatsky, Sasha,Hanly, John G,Isenberg, David,Rahman, Anisur,Merril John Wiley Sons 2014 Arthritis care & research Vol.66 No.8
<P>An association between 25-hydroxyvitamin D (25[OH]D; vitamin D) deficiency and increased cardiovascular (CV) risk factors and CV disease (CVD) has been shown in general population studies. Vitamin D deficiency has been noted in systemic lupus erythematosus (SLE), and CVD is a major cause of morbidity and mortality in SLE. The objectives of this study were to estimate the associations of 25(OH)D levels with CV risk factors and to determine whether low baseline 25(OH)D levels predict future CV events in patients participating in an international inception cohort.</P>
Bourr?-Tessier, Josiane,Urowitz, Murray B,Clarke, Ann E,Bernatsky, Sasha,Krantz, Mori J,Huynh, Thao,Joseph, Lawrence,Belisle, Patrick,Bae, Sang-Cheol,Hanly, John G,Wallace, Daniel J,Gordon, Caroline,I John Wiley Sons 2015 Arthritis care & research Vol.67 No.1
<P>To estimate the early prevalence of various electrocardiographic (EKG) abnormalities in patients with systemic lupus erythematosus (SLE) and to evaluate possible associations between repolarization changes (increased corrected QT [QTc] and QT dispersion [QTd]) and clinical and laboratory variables, including the anti-Ro/SSA level and specificity (52 or 60 kd).</P>
Control of inflammation by stromal Hedgehog pathway activation restrains colitis
Lee, John J.,Rothenberg, Michael E.,Seeley, E. Scott,Zimdahl, Bryan,Kawano, Sally,Lu, Wan-Jin,Shin, Kunyoo,Sakata-Kato, Tomoyo,Chen, James K.,Diehn, Maximilian,Clarke, Michael F.,Beachy, Philip A. National Academy of Sciences 2016 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.113 No.47
<P>Inflammation disrupts tissue architecture and function, thereby contributing to the pathogenesis of diverse diseases; the signals that promote or restrict tissue inflammation thus represent potential targets for therapeutic intervention. Here, we report that genetic or pharmacologic Hedgehog pathway inhibition intensifies colon inflammation (colitis) in mice. Conversely, genetic augmentation of Hedgehog response and systemic small-molecule Hedgehog pathway activation potently ameliorate colitis and restrain initiation and progression of colitis-induced adenocarcinoma. Within the colon, the Hedgehog protein signal does not act directly on the epithelium itself, but on underlying stromal cells to induce expression of IL-10, an immune-modulatory cytokine long known to suppress inflammatory intestinal damage. IL-10 function is required for the full protective effect of small-molecule Hedgehog pathway activation in colitis; this pharmacologic augmentation of Hedgehog pathway activity and stromal IL-10 expression are associated with increased presence of CD4(+) Foxp3(+) regulatory T cells. We thus identify stromal cells as cellular coordinators of colon inflammation and suggest their pharmacologic manipulation as a potential means to treat colitis.</P>
존 클락(John Clark) 현대미술사학회 2011 현대미술사연구 Vol.0 No.30
The complexity and historical depth of ‘The Asian Modern’ in art is indicated beginning with the Indonesian artists Raden Saleh (1811-1880), Sudjojono (1913-1986), and F. X. Harsono (born 1949). Discussion is then made of contemporaneity through examining the work of K.C.S Panicker in India and Park Seo-bo in Korea, before going back to the work of F.X. Harsono [Indonesia] compared with that of Zhang Peili [China] for the 1970s through to the 1990s. Reference is also made to problems the notion of contemporaneity in art itself as theorized by Smith and Enwezor, and where modern and contemporary art in Asia fits this discussion or does not.