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RISS 인기검색어
- 검색키워드
- 저자 : Johannes Albert Biben (검색결과 3 건)
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Free flap thrombosis in patients with hypercoagulability: A systematic review
Johannes Albert Biben,Parintosa Atmodiwirjo 대한성형외과학회 2019 Archives of Plastic Surgery Vol.46 No.6
Background Even with satisfactory anastomosis technique and adequate experience of thesurgeon, flap loss due to thrombosis can still occur due to the patient’s underlying condition. Patients with hypercoagulability due to etiologies such as malignancy, hereditary conditions,and acquired thrombophilia are among those who could benefit from free flap procedures. This review aimed to evaluate the risk of free flap thrombosis in patients with hypercoagulabilityand to identify the most effective thromboprophylaxis regimen. Methods This review was conducted in accordance with the Preferred Reporting Items forSystematic Reviews and Meta-Analyses guideline. The PubMed, Embase, and Cochrane Librarydatabases were explored. Types of free flaps, types of hypercoagulable states, thrombosis preventionprotocols, thrombosis complication rates, and flap vitality outcomes were reviewed. Samples from the included studies were pooled to calculate the relative risk of free flapthrombosis complications in patients with hypercoagulability compared to those without hypercoagulability. Results In total, 885 articles underwent title, abstract, and full-text screening. Six articlesmet the inclusion criteria. The etiologies of hypercoagulability varied. The overall incidence ofthrombosis and flap loss in hypercoagulable patients was 13% and 10.3%, respectively. Thethrombosis risk was two times higher in hypercoagulable patients (P=0.074) than in controls. Thromboprophylaxis regimens were variable. Heparin was the most commonly used regimen. Conclusions Hypercoagulability did not significantly increase the risk of free flap thrombosis. The most effective thromboprophylaxis regimen could not be determined due to variationin the regimens. Further well-designed studies should be conducted to confirm this finding.
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Free flap thrombosis in patients with hypercoagulability: A systematic review
Biben, Johannes Albert,Atmodiwirjo, Parintosa Korean Society of Plastic and Reconstructive Surge 2019 Archives of Plastic Surgery Vol.46 No.6
Background Even with satisfactory anastomosis technique and adequate experience of the surgeon, flap loss due to thrombosis can still occur due to the patient's underlying condition. Patients with hypercoagulability due to etiologies such as malignancy, hereditary conditions, and acquired thrombophilia are among those who could benefit from free flap procedures. This review aimed to evaluate the risk of free flap thrombosis in patients with hypercoagulability and to identify the most effective thromboprophylaxis regimen. Methods This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline. The PubMed, Embase, and Cochrane Library databases were explored. Types of free flaps, types of hypercoagulable states, thrombosis prevention protocols, thrombosis complication rates, and flap vitality outcomes were reviewed. Samples from the included studies were pooled to calculate the relative risk of free flap thrombosis complications in patients with hypercoagulability compared to those without hypercoagulability. Results In total, 885 articles underwent title, abstract, and full-text screening. Six articles met the inclusion criteria. The etiologies of hypercoagulability varied. The overall incidence of thrombosis and flap loss in hypercoagulable patients was 13% and 10.3%, respectively. The thrombosis risk was two times higher in hypercoagulable patients (P=0.074) than in controls. Thromboprophylaxis regimens were variable. Heparin was the most commonly used regimen. Conclusions Hypercoagulability did not significantly increase the risk of free flap thrombosis. The most effective thromboprophylaxis regimen could not be determined due to variation in the regimens. Further well-designed studies should be conducted to confirm this finding.
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Karina Karina,Krista Ekaputri,Johannes Albert Biben,Pritha Hadi,Hubert Andrew,Patricia Marcellina Sadikin 대한성형외과학회 2022 Archives of Plastic Surgery Vol.49 No.3
Although modern medicine hasmade great strides in the management of burn injuries, associated complications such as pain, infection, dyspigmentation, and scarring have yet to be fully dealt with. Although skin grafting and meshing are routinely performed on burn patients, this method poses a risk for adverse effects. Activated autologous platelet-rich plasma (aaPRP), which is increasingly used in the field of plastic surgery, contains growth factors beneficial for wound regeneration. Seven cases of burns with varying severity and conditions that were treated with intralesional subcutaneous injection and intravenous aaPRP are presented and discussed herein. This case series indicates that subcutaneous and intravenous aaPRP is a safe procedure with the potential to be an alternative when skin grafting cannot be done or as an adjunct treatment to skin grafting.
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