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Lee, Jung Hyun,Kong, Jinuk,Jang, Ju Yeon,Han, Ji Seul,Ji, Yul,Lee, Junho,Kim, Jae Bum American Society for Microbiology 2014 Molecular and cellular biology Vol.34 No.22
<P>Lipolysis is a delicate process involving complex signaling cascades and sequential enzymatic activations. In <I>Caenorhabditis elegans</I>, fasting induces various physiological changes, including a dramatic decrease in lipid contents through lipolysis. Interestingly, <I>C. elegans</I> lacks perilipin family genes which play a crucial role in the regulation of lipid homeostasis in other species. Here, we demonstrate that in the intestinal cells of <I>C. elegans</I>, a newly identified protein, <U>li</U>pid <U>d</U>roplet protein <U>1</U> (C25A1.12; LID-1), modulates lipolysis by binding to <U>a</U>dipose <U>t</U>ri<U>g</U>lyceride <U>l</U>ipase <U>1</U> (C05D11.7; ATGL-1) during nutritional deprivation. In fasted worms, lipid droplets were decreased in intestinal cells, whereas suppression of ATGL-1 via RNA interference (RNAi) resulted in retention of stored lipid droplets. Overexpression of ATGL-1 markedly decreased lipid droplets, whereas depletion of LID-1 via RNAi prevented the effect of overexpressed ATGL-1 on lipolysis. In adult worms, short-term fasting increased cyclic AMP (cAMP) levels, which activated protein kinase A (PKA) to stimulate lipolysis via ATGL-1 and LID-1. Moreover, ATGL-1 protein stability and LID-1 binding were augmented by PKA activation, eventually leading to increased lipolysis. These data suggest the importance of the concerted action of lipase and lipid droplet protein in the response to fasting signals via PKA to maintain lipid homeostasis.</P>
Lee, Jung Hyun,Han, Ji Seul,Kong, Jinuk,Ji, Yul,Lv, Xuchao,Lee, Junho,Li, Peng,Kim, Jae Bum American Society for Biochemistry and Molecular Bi 2016 The Journal of biological chemistry Vol.291 No.39
<P>Protein kinase A (PKA) is a cyclic AMP (cAMP)-dependent protein kinase composed of catalytic and regulatory subunits and involved in various physiological phenomena, including lipid metabolism. Here we demonstrated that the stoichiometric balance between catalytic and regulatory subunits is crucial for maintaining basal PKA activity and lipid homeostasis. To uncover the potential roles of each PKA subunit, Caenorhabditis elegans was used to investigate the effects of PKA subunit deficiency. In worms, suppression of PKA via RNAi resulted in severe phenotypes, including shortened life span, decreased egg laying, reduced locomotion, and altered lipid distribution. Similarly, in mammalian adipocytes, suppression of PKA regulatory subunits RI and RII via siRNAs potently stimulated PKA activity, leading to potentiated lipolysis without increasing cAMP levels. Nevertheless, insulin exerted anti-lipolytic effects and restored lipid droplet integrity by antagonizing PKA action. Together, these data implicate the importance of subunit stoichiometry as another regulatory mechanism of PKA activity and lipid metabolism.</P>
Comparative analysis of human facial skin microbiome between topical sites compared to entire face
Lee Haeun,Jeong Jinuk,Oh Yunseok,Lee Cherl-Jun,Mun Seyoung,Lee Dong-Geol,Jo HyungWoo,Heo Young Mok,Baek Chaeyun,Heo Chan Yeong,Kang So Min,한규동 한국유전학회 2021 Genes & Genomics Vol.43 No.12
Background Skin is an essential outer barrier and supports the growth of commensal microorganisms that protects a host from the ofense of foreign toxic organisms. With the rapid development of next-generation sequencing (NGS)-based applications, skin microbiome research for facial health care has reached industry growth, such as therapy and cosmetic product development. Despite the acceleration of skin microbiome research, experimental standardization protocol has not yet been established in the facial site and method of sampling. Objective Thus, we aimed to investigate the diferences in microbial composition at each facial site (cheek, mouth, forehead, and entire face) using comprehensive microbiome analysis. Methods Twelve specimens from three men (four specimens per one person) were collected. The hypervariable regions (V3–V4) of the bacterial 16S rRNA gene were targeted for 16S amplicon library construction and classifcation of bacterial taxonomy. Skin microbial composition for all specimens was investigated, and the diferences site-by-site in skin microbial composition were analyzed and evaluated by the various statistical tests. Results We were able to validate the independent correlation between the skin microbiome composition and the facial sites. The cheek site showed the highest alpha-diversity in richness and evenness scores compared to the forehead and mouth. The cheek and mouth sites showed a positive correlation (R2 value>0.93) with the entire face, while the forehead sites were negatively correlated (R2 value<0.2). Given the relative abundance based on statistical correlation analysis, we estimated that the cheek site could be considered an optimal topical site to replace the entire face. Conclusion Our study suggests that skin microbiome profling of four facial sites confrms that the cheek shows the most similar skin fora with the entire face. This study would be informative for preventing bias caused by sampling methods before researching and understanding skin cosmetics development or skin diseases.
Lee, Myunglyeol,Lee, Kuija,Kim, Jinuk International Academy of Physical Therapy Research 2021 Journal of International Academy of Physical Ther Vol.12 No.2
Background: Patients with dysphagia after stroke are treated with neuromuscular electrical stimulation (NMES), but its effect on masseter muscle thickness and bite force in the oral phase is not well known. Objectives: To investigated the effect of NMES on masseter muscle thickness and occlusal force in patients with dysphagia after stroke. Design: Two group, pre-post design. Methods: In this study, 25 patients with dysphagia after stroke were recruited and allocated to either the experimental or the control groups. Patients in the experimental group were treated with NMES to the masseter muscle at the motor level for 30 minutes and were additionally treated with traditional swallowing rehabilitation for 30 minutes. In contrast, patients in the control group were only treated with traditional swallowing rehabilitation for 30 minutes. Masseter muscle thickness was measured using ultrasonography before and after intervention, and bite force was measured using an bite force meter. Results: The experimental group showed significant improvement in masseter muscle thickness and bite force compared to the control group. Conclusion: NMES combined with traditional dysphagia rehabilitation is effective in improving masseter muscle thickness and bite force in patients with dysphagia after stroke.
수퍼캐패시터를 병용하는 전기자동차/하이브리드 전기자동차용 에너지저장시스템 개발
정진욱(Jinuk Jeong),이상돈(Sangdon Lee),이현동(Hyeoundong Lee) 한국자동차공학회 2002 한국자동차공학회 Symposium Vol.2002 No.11
The hybrid power system consists of batteries and super capacitors. The super capacitor contributes to the rapid<br/> energy recovery associated with regenerative braking and to the rapid energy consumption associated with<br/> acceleration in electric vehicles. In this paper, the physical property and equivalent model of super capacitor is<br/> included. The soft switching bi-directional DC-DC converter is used to connect the super capacitor with the battery<br/> for the controlled instantaneous electric power flow. The hybrid power system is analyzed and verified by<br/> experimental results from the 10 kW proto-type.
Comparative study of the effects of bupropion and escitalopram on Internet gaming disorder
Song, Jinuk,Park, Jeong Ha,Han, Doug Hyun,Roh, Sungwon,Son, Ji Hyun,Choi, Tae Young,Lee, Hyuk,Kim, Tae Ho,Lee, Young Sik FOLIA PUBLISHING SOCIETY 2016 PSYCHIATRY AND CLINICAL NEUROSCIENCES Vol.70 No.11
<P>Conclusion: Both bupropion and escitalopram were effective in treating and managing IGD symptoms. Moreover, bupropion appeared to be more effective than escitalopram in improving attention and impulsivity in IGD patients. In addition, attention and impulsivity seem to be important for the management of IGD.</P>
박진욱(Jinuk Park),이우람(Uram Lee),이재성(Jaesung Lee) 한국자동차공학회 2022 한국자동차공학회 부문종합 학술대회 Vol.2022 No.6
In a fuel cell system, air containing moisture. This air can freeze inside the Air-cut off valve. This makes it difficult to start the system in cold areas. In this paper, we propose a method of crushing ice using vibration.
Myunglyeol Lee,Jinuk Kim,Donghwan Oh,Kuija Lee 국제물리치료연구학회 2020 Journal of International Academy of Physical Ther Vol.11 No.3
Background: Recently, a new method of dysphagia rehabilitation using Kinesio taping (KT) has been attempted and demonstrated an immediate increase in the activation of the suprahyoid muscle during swallowing in healthy adults. Objectives: To investigate the effect of dysphagia rehabilitation using KT on the thickness change of the suprahyoid muscle in patients with dysphagia after stroke. Design: Two-group pre-post design. Methods: In this study, 20 patients with dysphagia after stroke were enrolled and assigned to the experimental and control groups. The experimental group applied KT to the front of the neck and repeatedly swallowed against the tension of the tape. On the other hand, the control group performed repeated swallowing without applying KT. Patients in both groups had swallowed 50 times a day/5 times a week for 4 weeks. For evaluation, the volume of the geniohyoid, mylohyoid, and digastric muscle was measured before and after the intervention using portable ultrasound equipment. Results: As a result of comparing the two groups after the intervention, the experimental group showed more volume increase in mylohyoid (P<.05) and digastric muscle (P<.05) than the control group. Conclusion: This study proved that suprahyoid muscle resistance exercise using KT is effective in increasing the volume of the suprahyoid muscle.