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- 저자 : Jing De Zhu (검색결과 6 건)
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Zhou, De,Xie, Wan-Zhuo,Hu, Ke-Yue,Huang, Wei-Jia,Wei, Guo-Qing,He, Jing-Song,Shi, Ji-Min,Luo, Yi,Li, Li,Zhu, Jing-Jing,Zhang, Jie,Lin, Mao-Fang,Ye, Xiu-Jin,Cai, Zhen,Huang, He Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2
Aim: To analyze the significance of different clinical factors for prognostic prediction in diffuse large B-cell lymphoma (DLBCL) patients. Methods: Two hundred and twenty-seven DLBCL patients were retrospectively reviewed. Patients were managed with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen or rituximab plus the CHOP (RCHOP) regimen. Results: Lactate dehydrogenase (LDH), ${\beta}2$-microglobulin (${\beta}2$-M), B symptoms, Ann Arbor stage and genetic subtypes were statistically relevant in predicting the prognosis of the overall survival (OS). In the CHOP group, the OS in patients with germinal center B-cell-like (GCB)(76.2%) was significantly higher than that of the non-GCB group (51.9%, P=0.032). With RCHOP management, there was no statistical difference in OS between the GCB (88.4%) and non-GCB groups (81.9%, P=0.288). Conclusion: Elevated LDH and ${\beta}2$-M levels, positive B symptoms, Ann Arbor stage III/IV, and primary nodal lymphoma indicate an unfavorable prognosis of DLBCL patients. Patients with GCB-like DLBCL have a better prognosis than those with non-GCB when treated with the CHOP regimen. The RCHOP treatment with the addition of rituximab can improve the prognosis of patients with DLBCL.
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Rice Production, Consumption and Trading in China (초)
( De Feng Zhu ),( Yu Ping Zhang ),( Jing Xiang ) 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2010 한국식품저장유통학회 학술대회 Vol.2010 No.-
China is the largest rice production country in the world. Chinese rice planting stands for 18.7 % of world rice planting area and contributes 28.5% of world rice production. Rice is a staple food in China. Its planting area and production stands for 27% and 38% of grain crops in China respectively. About 60% of the Chinese population lives on rice. Due to the decreasing rice area in the south, percentage of rice production in national grain production is decreasing in recent decades. Rice planting method is shifting from hand transplanting to labor saving planting methods, including seedling throwing, direct seeding and machine transplanting. Hybrid rice covers more than 55% of rice area. Average rice consumption per capita is 65.9 kg in the northeast and 120.9 in the south in the period from 2003 to 2009. In recent years, rice consumption per capita is decreasing by 3.3% in the northeast and 2.8% in the south annually. On the whole, the rice production in China will be sufficient to meet the consumption demand of the population in urban and rural areas. But there still exists a certain gap between the current production and domestic potential demand of quality rice in China, which will provide a great potential for rice trade. China imports and exports rice. Annual import rice is about 0.41 million ton and export 1.27million ton during the period from 1980 to 2009. Rice variety of import main is good quality rice, such as aromatic rice, while that of export main is Japonica and normal indica rice.
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An Experimental Model for Induction of Lung Cancer in Rats by Chlamydia Pneumoniae
Chu, De-Jie,Guo, Shui-Gen,Pan, Chun-Feng,Wang, Jing,Du, Yong,Lu, Xu-Feng,Yu, Zhu-Yuan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6
Objective: To assess induction effects of Chlamydia pneumoniae (Cpn) on lung cancer in rats. Methods: A lung cancer animal model was developed through repeated intratracheal injection of Cpn (TW-183) into the lungs of rats, with or without exposure to benzo(a)pyrene (Bp). Cpn antibodies (Cpn-IgA, -IgG, and -IgM) in serum were measured by microimmunofluorescence. Cpn-DNA or Cpn-Ag of rat lung cancer was detected through polymerase chain reaction or enzyme-linked immunosorbent assay. Results: The prevalence of Cpn infection was 72.9% (35/48) in the Cpn group and 76.7% (33/43) in the Cpn plus benzo(a)pyrene (Bp) group, with incidences of lung carcinomas in the two groups of 14.6% (7/48) and 44.2% (19/43), respectively (P-values 0.001 and <0.000 compared with normal controls). Conclusions: A rat model of lung carcinoma induced by Cpn infection was successfully established in the laboratory for future studies on the treatment, prevention, and mechanisms of the disease.
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Qing-Zhu Yang,Che Wang,Lei Lang,Yang Zhou,He Wang,De-Jing Shang 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.11
Recent advances in the search for novel anticanceragents have indicated that the positively chargedantimicrobial peptides have emerged as promising agentsoffering several advantages over the conventional anticancerdrugs. As a naturally occurring, cationic, a-helicalantimicrobial peptide, temproin-1CEa has been proved toexhibit a potent anticancer effect and a moderate hemolyticactivity. In order to reduce the hemolytic activity of temporin-1CEa and improve its anticancer potency towards arange of human breast cancer cells, in the present study, sixanalogs of temporin-1CEa were rationally designed andsynthesized. The amphipathicity levels and a-helicalstructural patterns of peptides were reserved, while theircationic property and hydrophobicity were changed. Theresults of MTT and hemolysis assay indicated that theanalog peptides displayed an improved anticancer activityand showed an overall optimized therapeutic index. Thehydrophobicity of peptides was positively correlated withtheir hemolytic and antitumor activities. Moreover, the datasuggest a strategy of increasing the cationicity whilemaintaining the moderate hydrophobicity of naturallyoccurring amphipathic a-helical peptides to generate analogswith improved cytotoxicity against tumor cells butdecreased activity against non-neoplastic cells such ashuman erythrocytes. This work highlights the potential forrational design and synthesis of improved antimicrobialpeptides that have the capability to be used therapeuticallyfor treatment of cancers.
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Shen, Xing-Rong,Chai, Jing,Feng, Rui,Liu, Tong-Zhu,Tong, Gui-Xian,Cheng, Jing,Li, Kai-Chun,Xie, Shao-Yu,Shi, Yong,Wang, De-Bin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24
The big gap between efficacy of population level prevention and expectations due to heterogeneity and complexity of cancer etiologic factors calls for selective yet personalized interventions based on effective risk assessment. This paper documents our research protocol aimed at refining and validating a two-stage and web-based cancer risk assessment tool, from a tentative one in use by an ongoing project, capable of identifying individuals at elevated risk for one or more types of the 80% leading cancers in rural China with adequate sensitivity and specificity and featuring low cost, easy application and cultural and technical sensitivity for farmers and village doctors. The protocol adopted a modified population-based case control design using 72, 000 non-patients as controls, 2, 200 cancer patients as cases, and another 600 patients as cases for external validation. Factors taken into account comprised 8 domains including diet and nutrition, risk behaviors, family history, precancerous diseases, related medical procedures, exposure to environment hazards, mood and feelings, physical activities and anthropologic and biologic factors. Modeling stresses explored various methodologies like empirical analysis, logistic regression, neuro-network analysis, decision theory and both internal and external validation using concordance statistics, predictive values, etc..
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