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- 저자 : Jinfang Wei (검색결과 3 건)
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High expression of RAD51 promotes DNA damage repair and survival in KRAS-mutant lung cancer cells
( Jinfang Hu ),( Zhiguo Zhang ),( Lei Zhao ),( Li Li ),( Wei Zuo ),( Lei Han ) 생화학분자생물학회(구 한국생화학분자생물학회) 2019 BMB Reports Vol.52 No.2
RAD51 recombinase plays a critical role in homologous recombination and DNA damage repair. Here we showed that expression of RAD51 is frequently upregulated in lung cancer tumors compared with normal tissues and is associated with poor survival (hazard ratio (HR) = 2, P = 0.0009). Systematic investigation of lung cancer cell lines revealed higher expression of RAD51 in KRAS mutant (MT) cells compared to wildtype (WT) cells. We further showed that MT KRAS, but not WT KRAS, played a critical role in RAD51 overexpression via MYC. Moreover, our results revealed that KRAS MT cells are highly dependent on RAD51 for survival and depletion of RAD51 resulted in enhanced DNA double strand breaks, defective colony formation and cell death. Together, our results suggest that mutant KRAS promotes RAD51 expression to enhance DNA damage repair and lung cancer cell survival, suggesting that RAD51 may be an effective therapeutic target to overcome chemo/radioresistance in KRAS mutant cancers. [BMB Reports 2019; 52(2): 151-156]
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Optimization of a twin-skeg container vessel by parametric design and CFD simulations
Chen, Jingpu,Wei, Jinfang,Jiang, Wujie The Society of Naval Architects of Korea 2016 International Journal of Naval Architecture and Oc Vol.8 No.5
The model tests results for the original lines of an 10000TEU container vessel show that the delivered power is higher and could not satisfy the requirement of energy saving effects and design targets. In this paper, the lines optimization of the 10,000 twin-skeg container vessel was carried out by parametric modeling and CFD simulations. At first, the CFD methods for twin-skeg hull form were validated by the comparison with the experimental results. Then more than one hundred parameters were adopted for the establishment of the fully parametric model. Based on the parametric model of the twin-skeg container vessel, the preliminary optimization was carried out by tight coupling of FRIENDSHIP-FRAMEWORK with potential flow of SHIPFLOW. Then several important parameters related to the after part of twin-skeg vessel were investigated by viscous flow computation. The final optimized variant PM11, which the total resistance was reduced by about 8.3% in model scale, is obtained within the constraints of general arrangement. And the model tests for variant PM11 was carried out in CSSRC, which shows that the resistance of optimized variant PM11 is decreased by about 8.6%.
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Optimization of a twin-skeg container vessel by parametric design and CFD simulations
Jingpu Chen,Jinfang Wei,Wujie Jiang 대한조선학회 2016 International Journal of Naval Architecture and Oc Vol.8 No.5
The model tests results for the original lines of an 10000TEU container vessel show that the delivered power is higher and could not satisfy the requirement of energy saving effects and design targets. In this paper, the lines optimization of the 10,000 twin-skeg container vessel was carried out by parametric modeling and CFD simulations. At first, the CFD methods for twin-skeg hull form were validated by the comparison with the experimental results. Then more than one hundred parameters were adopted for the establishment of the fully parametric model. Based on the parametric model of the twin-skeg container vessel, the preliminary optimization was carried out by tight coupling of FRIENDSHIPFRAMEWORK with potential flow of SHIPFLOW. Then several important parameters related to the after part of twin-skeg vessel were investigated by viscous flow computation. The final optimized variant PM11, which the total resistance was reduced by about 8.3% in model scale, is obtained within the constraints of general arrangement. And the model tests for variant PM11 was carried out in CSSRC, which shows that the resistance of optimized variant PM11 is decreased by about 8.6%.
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