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RISS 인기검색어
- 검색키워드
- 저자 : Jinatta Jittiwat (검색결과 2 건)
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Jinatta Jittiwat 사단법인약침학회 2017 Journal of Acupuncture & Meridian Studies Vol.10 No.5
The burden of stroke is high and is continually increasing due to a dramatic growth in the world’s elderly population. Novel therapeutic strategies are therefore required. The present study sought to determine the effect of laser acupuncture at GV20 on brain damage, oxidative-status markers in the cerebral cortex, and superoxide dismutase in the mitochondria of an animal model of focal ischemic stroke. Wistar rats, weighing 300e350 g, were divided into the following four groups: (1) control; (2) permanent occlusion of the right middle cerebral artery (Rt.MCAO) alone; (3) Rt.MCAO plus sham laser acupuncture; and (4) Rt.MCAO plus laser-acupuncture groups. Sham laser acupuncture or laser acupuncture was performed once daily at the GV20 (Baihui) acupoint for 14 days following Rt.MCAO. Half of the rats in each group were examined by 2,3,5- triphenyltetrazolium chloride staining to determine the brain infarct volume, while the other half were examined by biochemical assays to determine the malondialdehyde level, and the glutathione peroxidase, catalase, and superoxide-dismutase activities in the brain-cortex mitochondria. The results showed that laser acupuncture at GV20 significantly decreased the brain infarct volume and malondialdehyde level, and increased the catalase, glutathione peroxidase, and superoxide-dismutase activities in cerebral ischemic rats. In conclusion, laser acupuncture at GV20 decreases the brain infarct volume in cerebral ischemic rats, at least in part due to decreased oxidative stress. Further study is warranted to investigate other possible underlying mechanisms.
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Jintanaporn Wattanathorn,Jinatta Jittiwat 사단법인약침학회 2012 Journal of Acupuncture & Meridian Studies Vol.5 No.6
Recent findings have demonstrated that acupuncture and ginger can each improve memory impairment following cerebral ischemia. We hypothesized that ginger pharmacopuncture, a combination of these two treatments, could increase the beneficial effects. Due to the limitation of supporting evidence, we aimed to determine whether ginger pharmacopuncture could improve cognitive function and oxidative stress following cerebral ischemia. Male Wistar rats were induced by right middle cerebral artery occlusion (Rt. MCAO) and subjected to either acupuncture or ginger pharmacopuncture once daily over a period of 14 days after Rt. MCAO. Cognitive function was determined every 7 days, using escape latency and retention time as indices, and the oxidative stress status of the rats was determined at the end of the study. Rats subjected either to acupuncture or to ginger pharmacopuncture at GV20 demonstrated enhanced spatial memory, and the activities of catalase and glutathione peroxidase in both cerebral cortex and hippocampus were improved. Elevation of superoxide dismutase activity was observed only in the hippocampus. Cognitive enhancement was observed sooner with ginger pharmacopuncture than with acupuncture. The cognitive enhancing effect of acupuncture and ginger pharmacopuncture is likely to be at least partially attributable to decreased oxidative stress. However, other mechanisms may also be involved, and this requires further study.
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