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JinGu Lee,AeGyeong Seo,HeeDong Kim,YoungBo Lee2,SangHyun Lee,YoungKyu Park,HaeGil Lee,ChangSung Kang 한국응용곤충학회 2012 한국응용곤충학회 학술대회논문집 Vol.2012 No.05
Stick insect has several peculiarities like parthenogenesis, unique external features and dropping oviposition, so it is very hopeful to use for industrial insect. The oviposition was established by only female without fertilization with sperm of male which was not discovered during this study. The oviposition period was 37.3±14.9 days and the number of eggs per female was 41.5±16.5 eggs. The hatchability was 73.3% at 25℃and 66.7% after low temperature treatment(8℃, 60 days). The developmental periods and the length of egg were 100.9±4.2 days and 0.33±0.0cm, respectively, and the adult's life span was 49.7±16.0days. Differently other research which reported five nymph stage, the developmental stages of nymph showed five(62.9%) or six(37.1%) stages. The duration and the length of nymph increased according to the increase of nymph stage. Stick insect preferred the leaf of American locust, White oak, Chestnut, Bush clover in order but could be reared with food of the leaf of all these trees. Stick insects are herbivorus but made an attack each other when encountered in the small space. For sustaining mass rearing of stick insect, it is needed that the development of artificial diet and high density rearing method.
Comprehensive somatic genome alterations of urachal carcinoma
Lee, Seungchul,Lee, Jingu,Sim, Sung Hoon,Lee, Yeonghun,Moon, Kyung Chul,Lee, Cheol,Park, Woong-Yang,Kim, Nayoung KD,Lee, Se-Hoon,Lee, Hyunju BMJ Publishing Group Ltd 2017 Journal of medical genetics Vol.54 No.8
<P>Conclusions Our genome-wide analysis of urachal cancer suggests that molecular characteristics may be important for the treatment of urachal cancer.</P>
JinGu Lee,HeeDong Kim,ChangSung Kang,AeGyeong Seo,SangHyun Lee,YoungKyu Park,YoungBo Lee 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.04
Baculum elongatum has a long, thin shape that resembles a twig, propagates by parthenogenesis, changes body color, and drops eggs, all of which suggests its potential in the commercial market, especially as an educational pet insect. This study was carried out to determine the best hatching environment and an alternative or artificial diet for rearing B. elongatum to be developed as a commercial and educational pet insect. Oviposition was performed by females without fertilization by the sperm of males. The oviposition period was 42.2 ± 22.7 days and the number of eggs per female was 109.5 ± 70.5 eggs. The hatch rate was 73.3% at 25°C and 66.7% after low temperature treatment (8°C for 60 days). In nature, B. elongatum overwinters as an egg, but it can be assumed from the results that cold temperatures were not required for hatching. The hatch rate was 98.2% in the treatment using floral foam, fermented sawdust, and leaves. Clover(Trifolium repens) was an excellent diet as it was similar to the host plant and could be used as an alternative diet. The rate of reaching adulthood for the insects was 66.7% on an artificial diet containing 25% acacia leaves. For sustainable mass rearing of nymphs or adults of B. elongatum, a natural diet could be used such as acacia (Robinia pseudoacacia), white oak (Quercus aliena), chestnut (Castanea crenata var. dulcis), and bush clover (Lespedeza bicolor), or an alternative diet such as clover or artificial diet. To rear nymphs and adults of B. elongatum, natural diet such as acacia, white oak, chestnut, or bush clover leaves, or an alternative diet such as clover or an artificial diet can be used.
Lee, ChuHee,Park, Dae-Weon,Lee, Jingu,Lee, Tae-Il,Kim, Young-Jo,Lee, Yun-Sik,Baek, Suk-Hwan Elsevier 2006 european journal of pharmacology Vol.536 No.1
<P><B>Abstract</B></P><P>Phospholipase A<SUB>2</SUB> (PLA<SUB>2</SUB>) is an esterase that cleaves the <I>sn</I>-2 ester bond in glycerophospholipids, thereby releasing free fatty acids and lysophospholipids. In addition to the apoptotic activity of cytosolic PLA<SUB>2</SUB> and Ca<SUP>2+</SUP>-independent PLA<SUB>2</SUB>, recent studies showed that secretory PLA<SUB>2</SUB> (sPLA<SUB>2</SUB>) also play a role in apoptosis. However, the details of molecular mechanism have not been fully elucidated. Our data demonstrated that group IB PLA (IB PLA<SUB>2</SUB>)-exposed murine macrophage 264.7 cells showed characteristic features of apoptosis such as morphological changes, DNA laddering, staining positive for propidium iodide (PI) as well as Annexin V and activation of caspases and subsequent cleavage of poly (ADP-ribose) polymerase (PARP) in dose- and time-dependent manner. Moreover, IB PLA<SUB>2</SUB> was found to elicit tumor necrosis factor (TNF)-α production and release of cytochrome c, suggesting that IB PLA<SUB>2</SUB> exerts its apoptotic activity via the induction of TNF-α production and cytochrome c release, which results in triggering the activation of caspase cascade and PARP cleavage.</P>
JinGu Lee,AeGyeong Seo,JingYoung Kim,JeongA Han,ChangSung Kang,YoungSu Lee,SangHyun Lee 한국응용곤충학회 2014 한국응용곤충학회 학술대회논문집 Vol.2014 No.04
Childrena zenobia is very hopeful as an industrial insect for its beautiful color and long life span. This study was conducted to establish the mass rearing methods of C. zenobia to develop it as an industrial insect. C. zenobia appeared in the high mountains of about 1,000m above sea level at Pocheon and Gapyoung during high temperature season from July to August, and in the low mountains of about 400m above sea level at Yeoncheon on September. The first oviposition time after mating took 27.8±9.0 days and the number of eggs per female was 180. The life span of adult was 39.3±20.2 days in male and 59.0±18.7 days in female. The hatchability of F1 generation showed high rate over 80% at 20∼30℃, while the rate of F5 generation was very low under 5%. The proper food for rearing the larva was Viola papilionacea. The developmental period from 1st larva to adult was 63.6±5.1 days and the hatching time was 8.7±0.9 days at 20℃ and 48.0±3.3 days and the hatching time was 8.1±1.2 days at 25℃. These results seemed to be very suggestive that C. zenobia could be massively reared in the condition of indoor rearing room resulting in the utilization of it as an industrial insect for various regional festivals.
Lee, Yoon Suk,Kim, Haeryoung,Kim, Hyoung Woo,Lee, Jong-Chan,Paik, Kyu-Hyun,Kang, Jingu,Kim, Jaihwan,Yoon, Yoo-Seok,Han, Ho-Seong,Sohn, Insuk,Cho, Jeonghee,Hwang, Jin-Hyeok Williams & Wilkins Co 2015 Medicine Vol.94 No.50
<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>There is limited data on miRNA expression in pancreatic neuroendocrine tumors (PanNETs). In this study, we aimed to identify miRNAs that could be potential prognostic biomarkers of PanNETs in patients who underwent curative surgery.</P><P>For miRNA target screening, 2 primary PanNETs and corresponding liver metastases were screened for miRNA expression by the NanoString nCounter analysis. Candidate miRNAs were selected by ≥2-fold difference of expression between metastatic versus primary tumor. For miRNA target validation, quantitative real-time PCR was performed for candidate miRNAs on 37 PanNETs and matched nonneoplastic pancreata, and the miRNA levels were correlated with the clinicopathological features and patient survival data.</P><P>Eight miRNAs (miRNA-27b, -122, -142–5p, -196a, -223, -590–5p, -630, and -944) were selected as candidate miRNAs. Only miR-196a level was significantly associated with stage, and mitotic count. When PanNETs were stratified into high (n = 10) and low (n = 27) miRNA-196a expression groups, miRNA-196a-high PanNETs were significantly associated with advanced pathologic T stage (50.0% vs 7.4%), N stage (50.0% vs 3.7%), higher mitotic counts (60.0% vs 3.7%), and higher Ki-67-labeling indices (60.0% vs 22.2%). In addition, high miRNA-196a expression was significantly associated with decreased overall survival (<I>P</I> = 0.046) and disease-free survival (<I>P</I> < 0.001) during a median follow-up of 37.9 months with the hazard ratio for recurrence of 16.267 (95% confidence interval = 1.732–153.789; <I>P</I> = 0.015).</P><P>MiRNA-196a level may be a promising prognostic marker of recurrence in resected PanNETs, although further experimental investigation would be required.</P></▼2>
An R<sub>2</sub>* model of white matter for fiber orientation and myelin concentration
Lee, Jingu,Shin, Hyeong-Geol,Jung, Woojin,Nam, Yoonho,Oh, Se-Hong,Lee, Jongho Elsevier 2017 NeuroImage Vol.162 No.-
<P><B>Abstract</B></P> <P>Myelin, which consists of lipid bilayers, is one of the major constituents of white matter in the brain and has been suggested as a primary source of magnetic susceptibility contrasts. In this study, a new R<SUB>2</SUB>* model that simultaneously explains the effects of fiber orientation and myelin concentration is proposed and tested. In addition, a new approach that produces R<SUB>2</SUB>* maps without the effects of myelin is suggested. Experimental results demonstrate that the model reveals a high goodness of fit for the R<SUB>2</SUB>* distribution of white matter compared to a model that explains either fiber orientation or myelin concentration. The proposed R<SUB>2</SUB>* map shows a relatively uniform spatial distribution of R<SUB>2</SUB>* compared to the uncorrected R<SUB>2</SUB>* map and the fiber orientation or myelin concentration corrected R<SUB>2</SUB>* map.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new R2* model for fiber orientation and myelin concentration is proposed. </LI> <LI> The model explains the total myelin effects on R2* in white matter. </LI> <LI> The myelin effects on R2* were subtracted to generate a new myelin-removed R2* map. </LI> <LI> The corrected R2* map reveals reduced R2* heterogeneity in white matter. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Deep Learning in MR Image Processing
Lee, Doohee,Lee, Jingu,Ko, Jingyu,Yoon, Jaeyeon,Ryu, Kanghyun,Nam, Yoonho Korean Society of Magnetic Resonance in Medicine 2019 Investigative Magnetic Resonance Imaging Vol.23 No.2
Recently, deep learning methods have shown great potential in various tasks that involve handling large amounts of digital data. In the field of MR imaging research, deep learning methods are also rapidly being applied in a wide range of areas to complement or replace traditional model-based methods. Deep learning methods have shown remarkable improvements in several MR image processing areas such as image reconstruction, image quality improvement, parameter mapping, image contrast conversion, and image segmentation. With the current rapid development of deep learning technologies, the importance of the role of deep learning in MR imaging research appears to be growing. In this article, we introduce the basic concepts of deep learning and review recent studies on various MR image processing applications.
Health-enhancing Effects of feed supplemented with mealworm(Tenebrio molitor) on dog
Jingu Lee,Seung-Hwan Yun,Gab June Lim,Jae Eun Jang,Jieun Hwang,Seungju Lee,Sung Mo Yoon 한국응용곤충학회 2019 한국응용곤충학회 학술대회논문집 Vol.2019 No.04
Mealworm(Tenebrio molitor) was added to the feed to improve the health of dogs. As the amount of mealworm powder added to dog feed increased from 2.5 to 7.5%, the contents of crude protein, crude fat, crude fiber and crude ash increased. In the old dogs, creatinine and BUN related to nephropathy, triglyceride related to hypertension, calcium related to osteoporosis, globulin related to immunity, and ALT related to hepatic function were in the normal range. Particularly, ALT showed a tendency to increase overall, but the numerical increase tended to decrease as the amount of mealworm powder added. In the young dogs, all investigative items such as BUN and creatine were in the normal range and ALT tended to decrease at 2.5~5.0% treatment of mealworm. As a result, it was shown that adding 2.5~5.0% of mealworm powder to feed effectively improved the hepatic function of old and young dogs.