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Jing Jin,Yuanjin Chen,Dechuan Wang,Lingman Ma,Min Guo,Changlin Zhou,Jie Dou 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.6
Baicalin was identified as a neuraminidase (NA)inhibitor displaying anti-influenza A virus (IAV) activity. However, its poor solubility in saline has limited its use inthe clinic. We generated sodium baicalin and showed that itexhibited greatly increased solubility in saline. Its efficacyagainst oseltamivir-resistant mutant A/FM/1/47-H275Y(H1N1-H275Y) was evaluated in vitro and in vivo. Resultsshowed that 10 lM of sodium baicalin inhibited A/FM/1/47 (H1N1), A/Beijing/32/92 (H3N2) and H1N1-H275Y inMDCK cells in a dose-dependent manner, with inhibitoryrates of 83.9, 75.9 and 47.7%, respectively. Intravenousadministration of sodium baicalin at 100 mg/kg/d enabledthe survival of 20% of H1N1-H275Y-infected mice. Thetreatment alleviated body weight loss and lung injury. Moreover, sodium baicalin exerted a clear inhibitory effecton NAs. The IC50 values of sodium baicalin against H1N1-H275Y and cells-expressing A/Anhui/1/2013-R294K(H7N9-R294K) NA protein (N9-R294K) were 214.4 lMand 216.3 lM. Direct interactions between sodium baicalinand NA were observed, and we simulated the interactionsof sodium baicalin with N9-R294K and N9 near the activesites of OC-N9-R294K and OC-N9. The residues responsiblefor the sodium baicalin-N9-R294K and sodiumbaicalin-N9 interactions were the same, confirming thatsodium baicalin exerts effects on wild-type and oseltamivir-resistant viral strains.
Development of Water-cooling Transmission Device for Magnetorheological Fluid
Shuyou Wang,Fei Chen,Zuzhi Tian,Jin Dou,Xiangfan Wu 한국자기학회 2018 Journal of Magnetics Vol.23 No.2
Magnetorheological (MR) transmission that uses the rheological effect of MR fluid to transfer power is a new form of power transfer, which can achieve stepless control of torque and speed by adjusting the intensity of external magnetic field. In the study, a water-cooling heat dissipation scheme was proposed. The temperature simulation of MR transmission under natural heat dissipation and water-cooling heat dissipation was carried out by using the finite element method. Based on the design of the water-cooling MR transmission device (MRTD), the torque transmission and temperature rise characteristics of the MRTD were studied, and the influence of the heat dissipation mode on the transmission torque of the device was explored. Results show that the water-cooling method can control the temperature rise of the MRTD effectively.
Chemical Modification of Precursor Solution for Long Length YBCO Coated Conductor Fabrication
Yoo, Jaimoo,Kim, Young-Kuk,Chung, Kookchae,Ko, Jaewoong,Hong, Gye-Won,Lee, Hee-Gyoun,Kim, Jin-Heung,Chung, Hyungsik,Wang, X L,Dou, S X Institute of Physics Publishing Ltd 2006 Journal of Physics: Conference Series Vol.43 No.-
<P>Long length MOD processing of YBCO conductor requires high performance precursor solution without degradation during the process. In this study, effect of chemical modification of precursor solution on MOD processing was investigated to meet the requirement. Highly stable YBCO precursor solution was synthesized with PVP (polyvinylpyrrolidone) and crack-free thick precursor film was successfully fabricated. However, annealed YBCO film shows porous microstructures originated from large HF gas generation from thick films and residual carbon from additives. Reduction of fluorine content is required to densify microstructures. In order to reduce fluorine content, F-free Cu-precursor solution was synthesized. YBCO film with J<SUB>c</SUB>&equal;0.8MA/cm<SUP>2</SUP> was grown on buffered RABiTS tape. Annealed YBCO film still contains pores and further reduction of pores is required to improve critical current (I<SUB>c</SUB>)</P>