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      • KCI등재

        A reliable elasticity sensing method for analysis of cell entosis using microfluidic cytometer

        Jifeng Ren,Lei Fan 대한의용생체공학회 2023 Biomedical Engineering Letters (BMEL) Vol.13 No.2

        Cell entosis is a novel cell death process starting from cell-in-cell invasion. In general, cancer cells own higher incidencerate of cell entosis comparing to non-cancerous cells. Studies arguing whether cell entosis is a tumor suppressing processor a tumor accelerating process can deepen our understanding of tumor development. Cell elasticity is recognized as one oftumor malignant biomarkers. There have been some researchers studying cell elasticity in cell entosis. However, existingcell elasticity sensing technique (i.e. micropipette aspiration) can hardly be reliable neither high-throughput. In this work, weintroduce an elasticity sensing method for quantifying both cell elasticity in cell-in-cell structures and single floating cellsusing a microfluidic cytometer. We not only argue our cell elasticity sensing method is reliable for already occurred entosisbut also apply such method on predicting the “outer” cells in entosis of different cell types. The elasticity sensing methodproposed in this manuscript is able to provide an effective and reliable way to further study deeper mechanism in cell entosis.

      • Research on Electrical-Mechanical Energy Transfer Process of Vehicle Horn

        Jifeng Guo,Honge Ren,Zhiqiang Ma,Yan Ma 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.6

        Vehicle horn is a kind of electro acoustic device. The energy transfer process were analyzed through the energetic coil current, magnetic force, and displacement curves which had gotten before, and the process was happened in stage of the action, transaction and reciprocating vibration. The reasonable criterion for checking reciprocating vibration and sounding of horn was proposed, and the criterion was proved by changed the design parameters. The conclusions are of great value for further optimizing of reliability of the electro acoustic device such as electromagnetic horn.

      • Modified Smith Predictor Design and Its Applications to Long Time Delay Systems

        Honge REN,Xuehai CAO,Jifeng GUO 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.5

        For the system that can’t be described by the precise mathematical model and has long time delays, the conventional Smith predictor presents poor stability and large overshoot. Based on the conventional Smith predictor, an improved fuzzy adaptive PID-Smith predictor is proposed. It uses a fuzzy self-tuning PID controller as the primary controller instead of the traditional PID controller. In addition, a feedback loop and an adaptive regulator are imported to ensure the stability and enhance the adaptability of the variable environment. The simulation results show that the new scheme has excellent stability and robustness and can solve the problem of large overshoot in long time delay systems, even when the model mismatch rate comes to 40%.

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