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- 저자 : Jiaxi Zhou (검색결과 3 건)
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IDO promotes the proliferation and invasion of prostate cancer cells through KYNU
Zhou Hongqing,Wang Wei,Liu Mingsheng,Xie Pingbo,Deng Tibin,Peng Jiaxi,Xu Chenxiang 한국유전학회 2023 Genes & Genomics Vol.45 No.3
Background Prostate cancer (PCa) is one of the most common malignant tumors in male. Objective To explore the effect of indoleamine-2, 3-dioxygenase (IDO) on the proliferation and invasion of PCa cells and the potential mechanism. Methods PCa tissues and normal adjacent tissues were collected from 43 PCa patients. The expression of IDO in PCa tissues and cell lines were detected. The String website was used to search for IDO-related proteins. The GEPIA website was used to analyze the relationship between KYNU and the prognosis of PCa. Cells models of IDO overexpression and/or KYNU silencing were constructed to verify the role of KYNU in regulating PCa. The cell proliferation, apoptosis and invasion ability of PCa cells were detected by CCK-8 assay, Flow cytometry and Transwell assay. Results The IDO levels in PCa tissues and cells were higher than those in normal tissues and cells, which promoted the proliferation and invasion of LNCaP cells, and inhibited apoptosis. Silencing IDO inhibited the cells proliferation and invasion activities, and promoted the cell apoptosis. The high expression of KYNU was related to the poor disease free survival of PCa patients. Inhibiting KYUN significantly inhibited the promotion of PCa induced by IDO. Conclusion IDO is overexpressed in PCa, which promotes the proliferation and invasion of PCa cells, and the cancer-promoting mechanism may be related to KYNU.
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Design and homogenization of metal sandwich tubes with prismatic cores
Kai Zhang,Zichen Deng,Huajiang Ouyang,Jiaxi Zhou 국제구조공학회 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.45 No.4
Hollow cylindrical tubes with a prismatic sandwich lining designed to replace the solid cross-sections are studied in this paper. The sections are divided by a number of revolving periodic unit cells and three topologies of unit cells (Square, Triangle and Kagome) are proposed. Some types of multiple-topology designed materials are also studied. The feasibility and accuracy of a homogenization method for obtaining the equivalent parameters are investigated. As the curved elements of a unit cell are represented by straight elements in the method and the ratios of the lengths of the curved elements to the lengths of the straight elements vary with the changing number of unit cells, some errors may be introduced. The frequencies of the first five modes and responses of the complete and equivalent models under an internal static pressure and an internal step pressure are compared for investigating the scope of applications of the method. The lower bounds and upper bounds of the number of Square, Triangular and Kagome cells in the sections are obtained. It is shown that treating the multiple-topology designed materials as a separate-layer structure is more accurate than treating the structure as a whole.
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Design and homogenization of metal sandwich tubes with prismatic cores
Zhang, Kai,Deng, Zichen,Ouyang, Huajiang,Zhou, Jiaxi Techno-Press 2013 Structural Engineering and Mechanics, An Int'l Jou Vol.45 No.4
Hollow cylindrical tubes with a prismatic sandwich lining designed to replace the solid cross-sections are studied in this paper. The sections are divided by a number of revolving periodic unit cells and three topologies of unit cells (Square, Triangle and Kagome) are proposed. Some types of multiple-topology designed materials are also studied. The feasibility and accuracy of a homogenization method for obtaining the equivalent parameters are investigated. As the curved elements of a unit cell are represented by straight elements in the method and the ratios of the lengths of the curved elements to the lengths of the straight elements vary with the changing number of unit cells, some errors may be introduced. The frequencies of the first five modes and responses of the complete and equivalent models under an internal static pressure and an internal step pressure are compared for investigating the scope of applications of the method. The lower bounds and upper bounds of the number of Square, Triangular and Kagome cells in the sections are obtained. It is shown that treating the multiple-topology designed materials as a separate-layer structure is more accurate than treating the structure as a whole.
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