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- 저자 : Jian-Jing Jiang (검색결과 26 건)
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Jing Shen,Jilin Zhang,Jian Wan,Li Zhou,Ming Jiang 보안공학연구지원센터 2014 International Journal of Database Theory and Appli Vol.7 No.6
Stencils are finite-difference algorithms for solving large-scale and high-dimension partial differential equations. Due to the data dependences among the iterative statements in Stencils, traditional Stencil computations are be executed serially, rather than in parallel. It’s challenging to design an effective and scalable Stencil parallelized method. To address the issue of 3D data space computing, we present a serial execution model based on multi-layers symmetric Stencil method and time skewing techniques. Within this model, the iteration space is divided to multiple tiles based on time skewing, where the executive process is ordered by the sequence of tiles, and the nodes in each individual tile can be swept repeatedly to improve the data locality. In addition, we propose a novel 3D iterative space alternate tiling Stencil parallel method, which subdivides the iteration space along high dimension, and changes the execution sequence of tiles to reduce the data dependency and communication cost, where the partial order of tiles is still guaranteed. Experimental results demonstrate our proposed alternative tiling parallel method achieves better parallel efficiency and scalability compared with the domain-decomposition methods.
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NUMERICAL SIMULATION OF SYNOPTIC CONDITION ON A SEVERE SAND DUST STORM
JIANG, XUE-GONG,SHEN, JIAN-GUO,LIU, JING-TAO,CHUNG, YONG-SEUNG 한국교원대학교 환경과학연구소 2004 환경연구논문집 Vol.- No.8
By using observational data and MM5, an observational analysis and numerical study was conducted on the synoptic condition of a severe dust storm that was caused by a Mongolian cyclone which occurred from 6 to 8 April 2001. Results illustrated that the cyclogenesis was due to the isentropic potential voiticity (IPV) advection in the upper troposphere and the terrain modified baroclinicity in the mid-lower troposphere. The Altai-Sayan complex of mountains blocked the lower level cold air and made the isentropic surface sharply sleep. When the air slid down along the isentropic surface the increasing of baroclinicity and decreasing of stability blew up the vertical voiticity development. The formation of the dust storm was a result of a cyclonic cold front passing across the area. The occurrence of this dust storm was closely related to the strong surface wind, which was accompanied by a cold front passing, rather than the cyclogenesis, itself. Hence, the reason for the pre-front dust stonn formulation was the formation of heating convection. Reasons behind the formation of a black storm (visibility lower than 50 m), which occurred in the mid-north part of Inner Mongolia, lay in several aspects. Firstly, in this area the surface wind was strong, a direct result of the downward transport in mid-lower troposphere. Secondly, the cold front passed over the effected area near sunset so the air obtained much more surface heating to form a deeper mixed layer (ML). Thirdly, cooperation between the lower level wind and the terrain made the atmosphere in this area and acquired the maximum advective contribution necessary to form a deep post-front ML. The sensitivity experiment revealed that surface heal flux was important to the frontal lifting. In addition, the forcing of surface heating was also seen as the primary forcing mechanism of frontogenesis. Meanwhile, removal of the surface heat flux made the atmospheric stratification became stable and the pre-storm ML very shallow, which weakened the strength of the dust storm.
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Chen, Jing,Huang, Zhi-Jie,Duan, Yu-Qin,Xiao, Xin-Rong,Jiang, Jian-Qing,Zhang, Ru Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10
Aim: The present case-control study was conducted to explore the association of MTHFR gene polymorphism and relations of P16, MGMT and HMLH1 to MTHFR and folate intake. Methods: A total of 257 cases of esophageal squamous cell carcinoma confirmed by histopathological examination were collected. Genotyping of P16, MGMT and HMLH1 was accomplished by methylation-specific polymerase chain reaction (PCR) after sodium bisulfate modification of DNA and the MTHFR C677T genetic polymorphism was detected by PCR-restriction fragment-length polymorphism (PCR-RFLP). Results: The proportions of DNA hypermethylation in P16, MGMT and hMLH1 in cancer tissues were significantly higher than in paracancerous normal tissue. The proportion of hypermethylation in at least one gene was 88.5% in cancer tissue, and was also significantly higher than that in paracancerous normal tissue. Our finding showed individuals with homozygotes (TT) of MTHFR C677T had significant risk of DNA hypermethylation of MGMT in cancer tissues, with an OR (95% CI) of 3.15 (1.12-6.87). Similarly, patients with high intake of folate also showed a slight high risk of DNA methylation of MGMT, with OR (95% CI) of 2.03 (1.05-4.57). Conclusion: Our study found the P16, MGMT and hMLH1 demonstrate a high proportion of hypermethylation in esophageal squamous cell cancer cancer tissues, which might be used as biomarkers for cancer detection.
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Branched polymeric prodrug/programmed cell death 4 complexes for combinational cancer therapy
Yu‑Jing He,Lei Xing,Peng‑Fei Cui,Jia‑Liang Zhang,Jian‑Bin Qiao,Cheng‑Qiong Luo,Ge Jiang,Hu‑Lin Jiang 한국약제학회 2017 Journal of Pharmaceutical Investigation Vol.47 No.2
Here, we demonstrate a co-delivery system constructed by integrating chemotherapeutic molecules into branched polymeric prodrug which can condense nucleic acids. Demethylcantharidate (DCA) was chosen as a model drug and premodified through nucleophilic substitution reaction by its two carboxylic groups with allyl chloride. The synthesized intermediate (DCA-dially) was then used to polymerize with tris (2-aminoethyl) amine (TAEA) through progressively ammonolysis reaction. The obtained poly (DCA-alt-TAEA) (DCAT) was used to pack PDCD4 into spherical-like nanoparticles through electrostatic interaction. Gel retardation assays implied that DCAT could integrate DNA at the weight ratio of 1 and protect it from digestion by nuclease. Acid-base titration experiments showed that DCAT obtained preferable buffering capability which was beneficial for the endosomal escape of DCAT/PDCD4 complexes. Cellular tests involving gene transfection efficiency and cytotoxicity indicated that DCA and PDCD4 co-delivered by the complexes significantly and synergistically suppressed the viability of SMMC-7721 cells. These results suggest that integrating chemotherapeutic molecules into nucleic acid-packing polymeric prodrug as cationic polymer/PDCD4 complexes is a highly efficient way to co-deliver chemotherapeutic drugs and nucleic acids for cancer therapy.
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Li, Jing-Ping,Cao, Nai-Xia,Jiang, Ri-Ting,He, Shao-Jian,Huang, Tian-Ming,Wu, Bo,Chen, De-Feng,Ma, Ping,Chen, Li,Zhou, Su-Fang,Xie, Xiao-Xun,Luo, Guo-Rong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6
Background: GC-binding factor 2 (GCF2) is a transcriptional regulator that represses transcriptional activity of the epidermal growth factor receptor (EGFR) by binding to a specific GC-rich sequence in the EGFR gene promoter. In addition to this function, GCF2 has also been identified as a tumor-associated antigen and regarded as a potentially valuable serum biomarker for early human hepatocellular carcinoma (HCC) diagnosis. GCF2 is high expressed in most HCC tissues and cell lines including HepG2. This study focused on the influence of GCF2 on cell proliferation and apoptosis in HepG2 cells. Materials and Methods: GCF2 expression at both mRNA and protein levels in HepG2 cells was detected with reverse transcription (RT) PCR and Western blotting, respectively. RNA interference (RNAi) technology was used to knock down GCF2 mRNA and protein expression. Afterwards, cell viability was analyzed with a Cell Counting Kit-8 (CCK-8), and cell apoptosis and caspase 3 activity by flow cytometry and with a Caspase 3 Activity Kit, respectively. Results: Specific down-regulation of GCF2 expression caused cell growth inhibition, and increased apoptosis and caspase 3 activity in HepG2 cells. Conclusions: These primary results suggest that GCF2 may influence cell proliferation and apoptosis in HepG2 cells, and also provides a molecular basis for further investigation into the possible mechanism at proliferation and apoptosis in HCC.
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Liu, Jian-Lun,Wei, Wei,Tang, Wei,Jiang, Yi,Yang, Hua-Wei,Li, Jing-Tao,Zhou, Xiao Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7
Objective: The aim of this study was to investigate possible mechanisms of LOX gene effects on invasion and metastasis of breast cancer cells by RNA interference. Methods: LOX-RNAi-LV was designed, synthesized, and then transfected into a breast cancer cell line (MDA-MB-231). Expression of LOX, MMP-2 and MMP-9 was determined by real-time PCR, and protein expression of LOX by Western blotting. Cell migration and invasiveness were assessed with Transwell chambers. A total of 111 cases of breast cancer tissues, cancer-adjacent normal breast tissues, and 20 cases of benign lesion tissues were assessed by immunohistochemistry. Results: Expression of LOX mRNA and protein was suppressed, and the expression of MMP-2 and MMP-9 was significantly lower in the RNAi group than the control group (P<0.05), after LOX-RNAi-LV was transfection into MDA-MB-231 cells. Migration and invasion abilities were obviously inhibited. The expression of LOX protein in breast cancer, cancer-adjacent normal breast tissues and benign breast tumor were 48.6% (54/111), 26.1% (29/111), 20.0% (4/20), respectively, associations being noted with clinical stage, lymph node metastasis, tumor size and ER, PR, HER2, but not age. LOX protein was positively correlated with MMP-2 and MMP-9. Conclusion: LOX displayed an important role in invasion and metastasis of breast cancer by regulating MMP-2 and MMP-9 expression which probably exerted synergistic effects on the extracellular matrix (ECM).
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Ultimate behavior of long-span steel arch bridges
Cheng, Jin,Jiang, Jian-Jing,Xiao, Ru-Cheng,Xiang, Hai-Fan Techno-Press 2002 Structural Engineering and Mechanics, An Int'l Jou Vol.14 No.3
Because of the increasing span of arch bridges, ultimate capacity analysis recently becomes more focused both on design and construction. This paper investigates the static and ultimate behavior of a long-span steel arch bridge up to failure and evaluates the overall safety of the bridge. The example bridge is a long-span steel arch bridge with a 550 m-long central span under construction in Shanghai, China. This will be the longest central span of any arch bridge in the world. Ultimate behavior of the example bridge is investigated using three methods. Comparisons of the accuracy and reliability of the three methods are given. The effects of material nonlinearity of individual bridge element and distribution pattern of live load and initial lateral deflection of main arch ribs as well as yield stresses of material and changes of temperature on the ultimate load-carrying capacity of the bridge have been studied. The results show that the distribution pattern of live load and yield stresses of material have important effects on bridge behavior. The critical load analyses based on the linear buckling method and geometrically nonlinear buckling method considerably overestimate the load-carrying capacity of the bridge. The ultimate load-carrying capacity analysis and overall safety evaluation of a long-span steel arch bridge should be based on the geometrically and materially nonlinear buckling method. Finally, the in-plane failure mechanism of long-span steel arch bridges is explained by tracing the spread of plastic zones.
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