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Cefotaxime과 Furosemide의 賢排泄 및 血漿蛋白 結合에 미치는 影響
鄭址昌,金載學,韓大燮,高啓昌 慶熙大學校 1984 論文集 Vol.13 No.-
The cephalosporins are eliminated by both glomerular filtration and tubular excretion. Chronic administration of cephalosporins may cause renal tubular necrosis. Cefotaxime is a new semisynthetic cephalosporin antibiotic with an unusually broad antibacterial spectrum. Therefore, to determine whether any variations at plasma protein binding with furosemide by cefotaxime were responsible for its diuretic action of urine volume and electrolytes in rabbits, author studies effects on drug-interaction of cefotaxime and furosemide. The following results were obtained. 1. The group, administrated simultaneously furosemide and cefotaxime, was significantly increased compared with furosemide alone group on the urine volume, urinary electrolytes, because markedly increased the inhibition of Na^+ and Cl^- reabsorption in the renal tubule, and glomerular filtration rate without any differences. 2. Serum concentration of cefotaxime in rabbits was significanly elevated by the combination with furosemide, and markedly inhibited the elimination levels of cefotaxime in urine of rabbits. Conclusion of above results; Synergistic effect of cefotaxime on diuretic action of furosemide showed the comparative inhibition of plasma protein binding with furosemide by cefotaxime, and the continuation of diuretic effect seems excretion of furosemide on the in-hibited by competition between furosemide and cefotaxime in renal tubular excretion.
Ampicillin과 Furosemide의 相互作用에 관한 硏究
李昇宰,鄭址昌,高啓昌,韓大燮 慶熙大學校 1986 論文集 Vol.15 No.-
In order to investigate the durg-interaction between furosemide and ampicillin, the influences of ampicillin on the diuretic action of furosemide and the effects of furosemide on the urinary elimination rate and serum concentration of ampicillin were studied in the rabbits. In comparison of diuretic effects of furosemide alone group with those of furosemide-ampicillin combined group, the furosemide-ampicillin combined group showed significant increase in urine flow and urinary electrolytes amounts. Those findings seem to be resulted chiefly from marked inhibition of sodium and chloride reabsorption in the renal tubule without a little alteration of glomerular filtration rate. Throughout the combined administration of furosemide and ampicillin. the serum concentration of ampicillin were significantly elevated, but the urinary elimination rate of ampicillin were markedly decreased in the observed rabbits. It is concluded from the results that synergistic effect of ampicillin on diuretic action of furosemide might be due to the competitive inhibition of plasma protein binding with furosemide by ampicillin. It is also postulated that the competition between furosemide and ampicillin in renal tubular secretion.
羚羊角(Capricornidis Cornu)이 家兎血淸中 脂質含量 變化에 미치는 影響(Ⅰ)
鄭址昌,朴泰權,韓大燮 中央醫學社 1971 中央醫學 Vol.21 No.5
The effect of Capricornidis Cornu{C.C.) on the amount of total cholesterol, triglycerides, and phospholipid in serum from rabbit were observed. The crude drug was extracted by methanol, and extracted samples were orally administrated to the rabbits fasted for three days. After three days starvation, the amounts of total cholesterol and triglycerides in serum of the rabbit were markedly increased, while phospholipid was slightly decreased. The increased amounts of total cholesterol and triglycerides were gradually decreased by administration of the extracted samples, and were returned to the control levels after 15 days. However, the amount of phospholipid was increased to higher than the control levels by administration of the drug. According to the above results, it would be concluded that the extract of C. C. influences for the recovery of the increased amounts of total cholesterol and triglycerides by abnormal metabolism to normal on rabbit.
Induction of Apoptosis by a Stilbene Analog Involves Bax Translocation Regulated by p38 MAPK and Akt
Kwang Sup So,Ji Eun Oh,Jee Hye Han,정홍근,Young Suk Lee,김상희,천영진,김미영 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.4
trans-Stilbenes have been reported to induce cytochrome P450 1B1 (CYP1B1) inhibition and cell death, however, the molecular mechanisms of the effects are not fully understood. We report here that (1-(2-{3-[2-(2,4-dimethoxy-phenyl)-vinyl]-5-methoxy-phenoxy}ethyl)-1H-imidazole), a synthetic stilbene analog (SA) significantly suppressed TCDD-stimulated CYP1B1 mRNA expression. In HL-60 cells, SA induced apoptosis through activation of p38 MAPK and inactivation of Akt, which in turn activated Bad and mitochondrial death signaling pathway, as evidenced by Bax translocation and cytochrome c release. Expression of dominant negative p38 MAPK or constitutively active Akt significantly prevented cell death and mitochondrial Bax translocation, implicating that p38 MAPK and Akt signaling pathways play crucial roles in stilbene-induced apoptosis of HL-60 cells. These results suggest that SA induces apoptotic cell death as well as CYP1B1 inhibition and may thus be beneficial in cancer prevention