http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Jeahee Ryu (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Effect of Food Sensitivity on Overweight Assessed Using Food-Specific Serum Immunoglobulin G Levels
이민형,길현민,Eugene Cheon,김소연,Jeahee Ryu,Hayoung Khil,강충원,박승일,강석성,금나나,권영은 한국바이오칩학회 2021 BioChip Journal Vol.15 No.3
Food sensitivity is considered to be implicated in obesity via chronic inflammation. Obesity has become a global epidemic, and overweight is a gateway to obesity. Hence, understanding the effect of food sensitivity on overweight is important for public health. To examine the association between food sensitivity and overweight, we compared the levels of diverse serological IgGs (total IgG, food-specific IgG [sIgG], and total food-sIgG [the sum of food-sIgG]) between overweight and lean Korean adults. A total of 164 Koreans aged 19–29 years participated in the study. We collected serum samples, information on frequency of food consumption, and height and weight measures to calculate body mass index (BMI). Immunoassays were performed using protein microarrays to determine total IgG, food-sIgG for each of the 68 food antigens, and the total food-sIgG. Participants were classified as overweight (BMI ≥ 25 kg/m 2 ) or lean (BMI < 25 kg/m 2 ). The Wilcoxon rank-sum test was used to compare the decile scores of IgG values between the groups. The total IgG ( P = 0.58) and total food-sIgG scores ( P = 0.27) did not differ significantly between the groups, precluding chronic inflammation as the cause of overweight. However, in the overweight group, food-sIgG scores against dairy products and seafood were significantly higher ( P < 0.05), whereas those against fruit and vegetables were significantly lower ( P < 0.05). In overweight individuals, food-sIgG scores against milk were not associated with the actual consumption ( P = 0.76), suggesting higher food-sIgG as an indicator of higher sensitivity than of higher consumption. Higher sensitivity to dairy foods and seafood and lower sensitivity to fruit and vegetables are likely associated with weight gain. Future studies are warranted to understand the heterogeneous associations between food-sIgGs and overweight.
-
Jeon, Hyunjin,Lee, Euiyeon,Kim, Dahee,Lee, Minhyung,Ryu, Jeahee,Kang, Chungwon,Kim, Soyoun,Kwon, Youngeun American Chemical Society 2018 ANALYTICAL CHEMISTRY - Vol.90 No.16
<P>Live-cell-based biosensors have emerged as a useful tool for biotechnology and chemical biology. Genetically encoded sensor cells often use bimolecular fluorescence complementation or fluorescence resonance energy transfer to build a reporter unit that suffers from nonspecific signal activation at high concentrations. Here, we designed genetically encoded sensor cells that can report the presence of biologically active molecules via fluorescence-translocation based on split intein-mediated conditional protein trans-splicing (PTS) and conditional protein trans-cleavage (PTC) reactions. In this work, the target molecules or the external stimuli activated intein-mediated reactions, which resulted in activation of the fluorophore-conjugated signal peptide. This approach fully valued the bond-making and bond-breaking features of intein-mediated reactions in sensor construction and thus eliminated the interference of false-positive signals resulting from the mere binding of fragmented reporters. We could also avoid the necessity of designing split reporters to refold into active structures upon reconstitution. These live-cell-based sensors were able to detect biologically active signaling molecules, such as Ca<SUP>2+</SUP> and cortisol, as well as relevant biological stimuli, such as histamine-induced Ca<SUP>2+</SUP> stimuli and the glucocorticoid receptor agonist, dexamethasone. These live-cell-based sensing systems hold large potential for applications such as drug screening and toxicology studies, which require functional information about targets.</P> [FIG OMISSION]</BR>
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
