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- 저자 : Jared Bruce (검색결과 2 건)
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Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons
Roberson, David P,Gudes, Sagi,Sprague, Jared M,Patoski, Haley A W,Robson, Victoria K,Blasl, Felix,Duan, Bo,Oh, Seog Bae,Bean, Bruce P,Ma, Qiufu,Binshtok, Alexander M,Woolf, Clifford J Nature Publishing Group, a division of Macmillan P 2013 NATURE NEUROSCIENCE Vol.16 No.7
The peripheral terminals of primary sensory neurons detect histamine and non-histamine itch-provoking ligands through molecularly distinct transduction mechanisms. It remains unclear, however, whether these distinct pruritogens activate the same or different afferent fibers. Using a strategy of reversibly silencing specific subsets of murine pruritogen-sensitive sensory axons by targeted delivery of a charged sodium-channel blocker, we found that functional blockade of histamine itch did not affect the itch evoked by chloroquine or SLIGRL-NH2, and vice versa. Notably, blocking itch-generating fibers did not reduce pain-associated behavior. However, silencing TRPV1<SUP>+</SUP> or TRPA1<SUP>+</SUP> neurons allowed allyl isothiocyanate or capsaicin, respectively, to evoke itch, implying that certain peripheral afferents may normally indirectly inhibit algogens from eliciting itch. These findings support the presence of functionally distinct sets of itch-generating neurons and suggest that targeted silencing of activated sensory fibers may represent a clinically useful anti-pruritic therapeutic approach for histaminergic and non-histaminergic pruritus.
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Utku Uysal,Fethi Idiman,Egemen Idiman,Serkan Ozakbas,Sirel Karakas,Jared Bruce 대한신경과학회 2014 Journal of Clinical Neurology Vol.10 No.4
Background and Purpose The relationship between contingent negative variation (CNV),which is an event-related potential, and cognition in multiple sclerosis (MS) has not been examined previously. The primary objective of the present study was thus to determine the association between CNV and cognition in a sample of MS patients. Methods The subjects of this study comprised 66 MS patients [50 with relapsing-remittingMS (RRMS) and 16 with secondary progressive MS (SPMS)] and 40 matched healthy volunteers. A neuropsychological battery was administered to all of the subjects; CNV recordingswere made from the Cz, Fz, and Pz electrodes, and the amplitude and area under the curve(AUC) were measured at each electrode. Results RRMS patients exhibited CNVs with lower amplitudes and smaller AUCs than thecontrols at Pz. SPMS patients exhibited CNVs with lower amplitudes and smaller AUCs thanthe controls, and CNVs with a smaller amplitude than the RRMS patients at both Cz and Pz. After correcting for multiple comparisons, a lower CNV amplitude at Pz was significantly associated with worse performance on measures of speed of information processing, verbal fluency, verbal learning, and verbal recall. Conclusions CNV may serve as a marker for disease progression and cognitive dysfunctionin MS. Further studies with larger samples and wider electrode coverage are required to fullyassess the value of CNV in these areas.
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