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Ra Mi Lee,Rae Hyung Ryu,Seong Won Jeong,Soo Jin Oh,Hue Huang,Jin Soo Han,Chi Ho Lee,C. Justin Lee,Lily Yeh Jan,Sang Min Jeong 한국실험동물학회 2011 Laboratory Animal Research Vol.27 No.2
To clone the first anion channel from Xenopus laevis (X. laevis), we isolated a calcium-activated chloride channel (CLCA)-like membrane protein 6 gene (CMP6) in X. laevis. As a first step in gene isolation, an expressed sequence tags database was screened to find the partial cDNA fragment. A putative partial cDNA sequence was obtained by comparison with rat CLCAs identified in our laboratory. First stranded cDNA was synthesized by reverse transcription polymerase-chain reaction (RT-PCR) using a specific primer designed for the target cDNA. Repeating the 5’ and 3’ rapid amplification of cDNA ends, fulllength cDNA was constructed from the cDNA pool. The full-length CMP6 cDNA completed via 5’- and 3’-RACE was 2,940 bp long and had an open reading frame (ORF) of 940 amino acids. The predicted 940 polypeptides have four major transmembrane domains and showed about 50% identity with that of rat brain CLCAs in our previously published data. Semi-quantification analysis revealed that CMP6 was most abundantly expressed in small intestine, colon and liver. However, all tissues except small intestine, colon and liver had undetectable levels. This result became more credible after we did real-time PCR quantification for the target gene. In view of all CLCA studies focused on human or murine channels, this finding suggests a hypothetical protein as an ion channel, an X. laevis CLCA.
갑상선 수술시 발견된 비회귀성 후두신경 ; 유형, 동반 혈관 이상, 신경 손상 예방에 대한 고찰
이잔디(Jan dee Lee),남기현(Kee Hyun Nam),임치영(Chi Young Lim),윤지섭(Ji Sup Yun),정웅윤(Woong Youn Chung),박정수(Cheong Soo Park),장항석(Hang Seok Chang) 대한두경부종양학회 2006 대한두경부 종양학회지 Vol.22 No.1
Purpose: The nonrecurrent laryngeal nerve(NRLN) is a rare anomaly that is associated with the developmentally aberrant subclavian artery. Although rare on the right side and exceptional on the left, an aberrant nonrecurrent pathway for RLN represents a major surgical risk. Three course variations of right NRLN can be distinguished: descending(type I) , horizontal(type II), ascending(type III). This study is performed to characterize the variations of NRLN, associated vascular anomaly, and proper surgical methods for preventing nerve damage. Materials and Methods: Between January 1998 and March 2006 3,381 thyroidectomy were performed at our institution, and during these operations a nonrecurrent laryngeal nerve was observed in 13 cases (0.38%). There were 1 men and 12 women with a median age of 48 years(range 28-57). All of them are identified on the right side. Results: In all cases, there were no clinical symptoms observed preoperatively. The nerve anomaly was diagnosed preoperatively in only one case. There were type I variations of right RLN in 2 cases and type II variations in 11 cases. The retroesophageal aberrant right subcalvian artery; no innominate(brachiocephalic) artery was found and the right common carotic artery was arising directly from the aortic arch, was seen in 12 cases. A vocal cord palaysis caused by NRLN damage during operation was observed in one patient(7.6%) , where the nerve was close to the superior thyroid artery. No other complications were noted. Conclusion: It can be possible to predict NRLN from signs associated with the vascular anomaly; clinical symptoms or imaging studies. When an vascular anomaly is not detected preoperatively, overlooking possibility of NRLN may lead to severe operative morbidity. Hence, It is most important to identify all the thyroid structures carefully during thyroid surgery and to be aware of the possibility of anatomic variations of RLN.
이잔디(Jan dee Lee),윤종호(Jong Ho Yoon),장항석(Hang Seok Chang),박정수(Cheong Soo Park) 대한두경부종양학회 2004 대한두경부 종양학회지 Vol.20 No.1
Background and Objectives: Brain metastasis from well-differentiated thyroid carcinoma is uncommon, and the treatment remains controversial. In this study, we analyzed cases of brain metastasis from well differentiated thyroid carcinoma to determine optimal treatment. Material and Methods: From March 1986 to May 2003, we experienced 13 cases of brain metastases from well-differentiated thyroid carcinomas. There were 6 men and 7 women with a mean age of 62.3 years. The time interval detecting the brain metastasis, treatment methods, outcomes, and the prognostic factors were analyzed. Results: In 11 patients, brain metastasis was found at a mean of 96 months after thyroid surgery (range, 1-204months). In 1 patient, brain metastasis was found simultaneously with the thyroid cancer. In the remaining one, brain metastasis was presented as the first sign. Treatment included gamma knife therapy in 2, external radiation therapy (ExRT) in 2, resection and ExRT in 2, gamma knife therapy and ExRT in 2 and intracranial holmium injection in 1. Three patients received no treatment. The mean survival was 20.5months (1-119 months). Only 2 patients with early detection remained alive after treatment (23months and 119months). The age, sex, primary tumor size, combined organs of distant metastasis and treatment methods did not affect the prognosis. There were noticeable symptomatic improvements in patients who received any kind of treatment for brain metastasis. Conclusion: Early detection and treatment of brain metastasis appears to bring symptomatic relief and improve survival. Therefore, early screening for brain metastasis is recommended for patients with symptoms. However, further study is needed to determine the optimal method of treatment.
Lim, Ji Soo,Lee, Jin Hong,Ikeda-Ohno, Atsushi,Ohkochi, Takuo,Kim, Ki-Seok,Seidel, Jan,Yang, Chan-Ho American Physical Society 2016 Physical Review B Vol.94 No.3
<P>The multiferroic BiFeO3 (BFO) as a charge-transfer-type insulator is an interesting system in which to explore correlated electronic conduction. Here, we substitute divalent Ca ions into the parent BFO and apply an external electric field at elevated temperatures to spatially redistribute spontaneously created oxygen vacancies, thereby generating hole carriers in regions of less dense oxygen-vacancy concentrations. X-ray diffraction and photoemission spectroscopic measurement are employed to quantify a large variation of local oxygen-vacancy concentration, as much as similar to 10(21) cm(-3), and explore the consequent evolution of electronic band structure. We find that a nonrigid polaronic band is created by hole doping as a result of a strong electron-lattice coupling. We also show strong evidence for the disorder-driven formation of a Coulomb-glass state through electronic transport measurements on a quantitative level. These spectroscopic and transport results can be combined and understood in the framework of intrinsic spatial inhomogeneity of the polaronic charge density. The finding not only offers a promising platform and methodology for examining the interplay of functional defects and correlated electronic behaviors, but also suggests a unique electronic conduction mechanism applicable to systems with coexistence of strong electron correlation, electron-lattice interaction, and randomness beyond the Coulomb-glass physics in semiconductors.</P>
The Nonexistence of Conformal Deformations on Riemannian Warped Product Manifolds
Yoon-Tae Jung, Jan-Dee Kim, Eun-Hee Choi, Soo-Young Lee 조선대학교 기초과학연구원 2012 조선자연과학논문집 Vol.5 No.1
In this paper, when N is a compact Riemannian manifold, we discuss the nonexistence of conformal deformations on Riemannian warped product manifold M = (a, ∞)×f N with prescribed scalar curvature functions.
The Nonexistence of Conformal Deformations on Riemannian Warped Product Manifolds
Jung, Yoon-Tae,Kim, Jan-Dee,Choi, Eun-Hee,Lee, Soo-Young The Basic Science Institute Chosun University 2012 조선자연과학논문집 Vol.5 No.1
In this paper, when N is a compact Riemannian manifold, we discuss the nonexistence of conformal deformations on Riemannian warped product manifold $M=({\alpha},\;{\infty}){\times}_fN$ with prescribed scalar curvature functions.