http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation
Lim, Jaechul,Kim, Dongwan,Lee, Young-suk,Ha, Minju,Lee, Mihye,Yeo, Jinah,Chang, Hyeshik,Song, Jaewon,Ahn, Kwangseog,Kim, V. Narry American Association for the Advancement of Scienc 2018 Science Vol.361 No.6403
<P>RNA tails play integral roles in the regulation of messenger RNA (mRNA) translation and decay. Guanylation of the poly(A) tail was discovered recently, yet the enzymology and function remain obscure. Here we identify TENT4A (PAPD7) and TENT4B (PAPD5) as the enzymes responsible for mRNA guanylation. Purified TENT4 proteins generate amixed poly(A) tail with intermittent non-adenosine residues, the most common of which is guanosine. A single guanosine residue is sufficient to impede the deadenylase CCR4-NOT complex, which trims the tail and exposes guanosine at the 3' end. Consistently, depletion of TENT4A and TENT4B leads to a decrease in mRNA half-life and abundance in cells. Thus, TENT4A and TENT4B produce a mixed tail that shields mRNA from rapid deadenylation. Our study unveils the role of mixed tailing and expands the complexity of posttranscriptional gene regulation.</P>
일부 소음 특수건강검진 수검자에서 좌우 청력역치 비대칭의 분포
이수진,송재철,김경래,권영준 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.3
Objectives: Noise-induced hearing loss(NIHL) is characterized by bilaterally symmetrical hearing loss, but some screening audiometries of employees who were exposed noise showed asymmetry. Therefore, this study was carried out to evaluate distribution of asymmetrical hearing loss and factors influencing asymmetries. Methods : Study subjects were 294 male employees who have participated in 1st and 2nd noise-specific health examination. Results : The interaural threshold difference of 20 dB or more at 4,000 Hz was classified as asymmetry. Among 294 NIHL employees, 19% and left asymmetric hearing loss, 22% had right asymmetric hearing loss, land overall asymmetry were 41%. Prevalence of asymmetry at 4,000 Hz significantly more decreased in middle(80-84 dB(A) and high-level noise exposure groups(≥85 dB(A) than low-level exposure group and significantly increased as greater hearing threshold level in the worse ear. Prevalence of left asymmetry at 4,000 Hz significantly in creased as greater hearing threshold level in the worse ear than right asymmetry. The interaural difference was significantly greater in the left asymmetry. Conclusions : Noise exposure produced asymmetric hearing loss(interaural asymmetry was 20 dB and more in 41% of case) and left ear was more susceptible to noise demage than right ear.