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- 저자 : J.TIMOTHY CANNON (검색결과 1 건)
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Analgesic effects of electrical brain stimulation and stress
J.TIMOTHY CANNON,JOHN C. LIEBESKIND 경희대학교 동서의학연구소 1989 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1989 No.3
It has been 20 years since Melzack and Wall [1965]published their Gate Control Theory of pain. Included in this seminal work was a proposal that the brain could modulate the processing of nociceptive information at the spinal level. At that time, very little was known about the specifics of such a descending system. Particularly during the past decade, however, there has been rapid expansion of information concerning endogenous pain-inhibitory mechanisms. Models of the neural circuitry underlying pain intricate [Basbaum and Fields,1978, 1984]. Similarly, there is growing appreciation that responses to noxious sitmalation rely upon complex interactions between environement and organism. This review will focus on the analgesic effects of electrical brain stmulation (stimulation-produced analgesia) and some forms of stress (stress-induced analgesia). Research in these areas has provided some of the first glimpses of the nearal and biochemical bases of endogenous pain modulation. Additionally, it has contributed to our understanding of variables that define when these systems are called into play. Researchers in this field hope that such insights will contribute to more effective management of clinical pain states. With this goal in mind it is gratifying that there has already been a rapid transition from basic animal research [Mayer et al., 1971, Reynolds, 1969]to successful clinical trials in which electrical brain stmulation effectively attenuates some chronic pain states in man [Adams, 1976 ; Hosobuchi et al., 1977 : Richardson and Akil, 1977a, b].
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