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      • 돼지개량을 위한 과학적 육종

        J.R. Walters 대한양돈협회 1990 養豚 Vol.12 No.8

        돼지의 유전적 개량이론은 수십년간 이미 존재해 왔으며 영국의 양돈산업은 영국정부와 종돈 육종회사의 "피라밋" 돈군조직을 활용한 매우 적극적인 사업계획으로 인하여 개량에 대한 과학기술의 이해 및 보급,개량의 실현에 특별히 성공적이었다. 이 시스템에서는 핵돈군에 있어 순종이나 합성종계통에서 유전적 진보가 일어난다

      • SCISCIESCOPUS

        EMPIRICAL DETERMINATION OF CONVECTION PARAMETERS IN WHITE DWARFS. I. WHOLE EARTH TELESCOPE OBSERVATIONS OF EC14012-1446

        Provencal, J. L.,Montgomery, M. H.,Kanaan, A.,Thompson, S. E.,Dalessio, J.,Shipman, H. L.,Childers, D.,Clemens, J. C.,Rosen, R.,Henrique, P.,Bischoff-Kim, A.,Strickland, W.,Chandler, D.,Walter, B.,Wat IOP Publishing 2012 The Astrophysical journal Vol.751 No.2

        <P>We report on an analysis of 308.3 hr of high-speed photometry targeting the pulsating DA white dwarf EC14012-1446. The data were acquired with the Whole Earth Telescope during the 2008 international observing run XCOV26. The Fourier transform of the light curve contains 19 independent frequencies and numerous combination frequencies. The dominant peaks are 1633.907, 1887.404, and 2504.897 mu Hz. Our analysis of the combination amplitudes reveals that the parent frequencies are consistent with modes of spherical degree l = 1. The combination amplitudes also provide m identifications for the largest amplitude parent frequencies. Our seismology analysis, which includes 2004-2007 archival data, confirms these identifications, provides constraints on additional frequencies, and finds an average period spacing of 41 s. Building on this foundation, we present nonlinear fits to high signal-to-noise light curves from the SOAR 4.1 m, McDonald 2.1 m, and KPNO 2 m telescopes. The fits indicate a time-averaged convective response timescale of tau(0) = 99.4 +/- 17 s, a temperature exponent N = 85 +/- 6.2, and an inclination angle of theta(i) = 32 degrees.9 +/- 3 degrees.2. We present our current empirical map of the convective response timescale across the DA instability strip.</P>

      • SCIE

        Evaluation of decellularization protocols for production of tubular small intestine submucosa scaffolds for use in oesophageal tissue engineering

        Syed, O.,Walters, N.J.,Day, R.M.,Kim, H.W.,Knowles, J.C. Elsevier BV 2014 ACTA BIOMATERIALIA Vol.10 No.12

        Small intestine submucosa (SIS) has emerged as one of a number of naturally derived extracellular matrix (ECM) biomaterials currently in clinical use. In addition to clinical applications, ECM materials form the basis for a variety of approaches within tissue engineering research. In our preliminary work it was found that SIS can be consistently and reliably made into tubular scaffolds which confer certain potential advantages. Given that decellularization protocols for SIS are applied to sheet-form SIS, it was hypothesized that a tubular-form SIS would behave differently to pre-existing protocols. In this work, tubular SIS was produced and decellularized by the conventional peracetic acid-agitation method, peracetic acid under perfusion along with two commonly used detergent-perfusion protocols. The aim of this was to produce a tubular SIS that was both adequately decellularized and possessing the mechanical properties which would make it a suitable scaffold for oesophageal tissue engineering, which was one of the goals of this work. Analysis was carried out via mechanical tensile testing, DNA quantification, scanning electron and light microscopy, and a metabolic assay, which was used to give an indication of the biocompatibility of each decellularization method. Both peracetic acid protocols were shown to be unsuitable methods with the agitation-protocol-produced SIS, which was poorly decellularized, and the perfusion protocol resulted in poor mechanical properties. Both detergent-based protocols produced well-decellularized SIS, with no adverse mechanical effects; however, one protocol emerged, SDS/Triton X-100, which proved superior in both respects. However, this SIS showed reduced metabolic activity, and this cytotoxic effect was attributed to residual reagents. Consequently, the use of SIS produced using the detergent SD as the decellularization agent was deemed to be the most suitable, although the elimination of the DNase enzyme would give further improvement.

      • Insulating phases of vanadium dioxide are Mott-Hubbard insulators

        Huffman, T. J.,Hendriks, C.,Walter, E. J.,Yoon, Joonseok,Ju, Honglyoul,Smith, R.,Carr, G. L.,Krakauer, H.,Qazilbash, M. M. American Physical Society 2017 Physical Review B Vol.95 No.7

        <P>We present comprehensive broadband optical spectroscopy data on two insulating phases of vanadium dioxide (VO2): monoclinic M-2 and triclinic. The main result of our work is that the energy gap and the electronic structure are essentially unaltered by the first-order structural phase transition between the M-2 and triclinic phases. Moreover, the optical interband features in the M-2 and triclinic phases are remarkably similar to those observed in the well-studied monoclinic M-1 insulating phase of VO2. As the energy gap is insensitive to the different lattice structures of the three insulating phases, we rule out vanadium-vanadium pairing (the Peierls component) as the dominant contributor to the opening of the gap. Rather, the energy gap arises primarily from intra-atomic Coulomb correlations.</P>

      • IDENTIFICATION CAMPAIGN OF SUPERNOVA REMNANT CANDIDATES IN THE MILKY WAY. I.<i>CHANDRA</i>OBSERVATION OF G308.3-1.4

        Hui, C. Y.,Seo, K. A.,Huang, R. H. H.,Trepl, L.,Woo, Y. J.,Lu, T.-N.,Kong, A. K. H.,Walter, F. M. IOP Publishing 2012 The Astrophysical journal Vol.750 No.1

        <P>ROSAT all-sky survey data have provided another window in which to search for supernova remnants (SNRs). In re-examining this data archive, a list of unidentified extended X-ray objects have been suggested as promising SNR candidates. However, most of these targets have not yet been fully explored by state-of-the-art X-ray observatories. To select a pilot target for a long-term identification campaign, we observed the brightest candidate, G308.3-1.4, with the Chandra X-ray Observatory. An incomplete shell-like X-ray structure that is well correlated with the radio shell emission at 843 MHz has been revealed. The X-ray spectrum suggests the presence of a shock-heated plasma. All these evidences confirm G308.3-1.4 as an SNR. The brightest X-ray point source detected in this field of view is also the one located closest to the geometrical center of G308.3-1.4, which has a soft spectrum. The intriguing temporal variability and the identification of the optical/infrared counterpart rule out the possibility of an isolated neutron star. On the other hand, the spectral energy distribution from the K-s band to the R band suggests a late-type star. Together with a putative periodicity of similar to 1.4 hr, the interesting excesses in the V and B bands and in H alpha suggest that this source is a promising candidate for a compact binary that survived a supernova explosion.</P>

      • The Effect of Botox Injections on the Mechanical Properties of Skinned Fibres from Rabbit Paraspinal Muscles

        S. K. Han(한상규),Kevin R Boldt,K. J. Chun(전경진),Walter Herzog,Venus Joumaa Korean Society for Precision Engineering 2021 한국정밀공학회 학술발표대회 논문집 Vol.2021 No.11월

        Botulinum toxin type A (BTX-A) has been widely used for the treatment of muscle stiffness and hyperactivity, such as spasticity and dystonia in patients post-stroke or children with Cerebral Palsy. However, BTX-A injection has been shown to cause muscle atrophy, fat infiltration, fibrosis, and decreased force output in target muscles, but its potential effects on the contractile machinery and force production on the cellular level remain unknown. The aim of this study was to investigate the effects of BTX-A injections on the mechanical properties of skinned fibres from rabbit paraspinal muscles. Nineteen-month-old rabbits received either saline or BTX-A injections into the paraspinal muscles, equally distributed along the left and right sides of the spine at T12, L1, and L2 for five times during 24 weeks. Fibres were tested for their active and passive force-length relationships, unloaded shortening velocity and myosin heavy chain isoforms. BTX-A injections led to significant fat infiltration within the injected muscles and a greater proportion of IIa to IIx fibres. Single fast fibres from BTX-A injected animals had lower active force and unloaded shortening velocity compared to fibres from saline-injected control animals. Force and velocity properties were not affected by BTX-A injections for the slow fibres.

      • SCOPUSKCI등재

        Utility of a modified components separation for abdominal wall reconstruction in the liver and kidney transplant population

        Black, Cara K,Zolper, Elizabeth G,Walters, Elliot T,Wang, Jessica,Martinez, Jesus,Tran, Andrew,Naz, Iram,Kotha, Vikas,Kim, Paul J,Sher, Sarah R,Evans, Karen K Korean Society of Plastic and Reconstructive Surge 2019 Archives of Plastic Surgery Vol.46 No.5

        Background Incisional hernia is a common complication following visceral organ transplantation. Transplant patients are at increased risk of primary and recurrent hernias due to chronic immune suppression and large incisions. We conducted a retrospective review of patients with a history of liver or kidney transplantation who underwent hernia repair to analyze outcomes and hernia recurrence. Methods This is a single center, retrospective review of 19 patients who received kidney and/or liver transplantation prior to presenting with an incisional hernia from 2011 to 2017. All hernias were repaired with open component separation technique (CST) with biologic mesh underlay. Results The mean age of patients was $61.0{\pm}8.3years\;old$, with a mean body mass index of $28.4{\pm}4.8kg/m^2$, 15 males (78.9%), and four females (21.1%). There were seven kidney, 11 liver, and one combined liver and kidney transplant patients. The most common comorbidities were hypertension (16 patients, 84.2%), diabetes (9 patients, 47.4%), and tobacco use (8 patients, 42.1%). Complications occurred in six patients (31.6%) including hematoma (1/19), abscess (1/19), seroma (2/19), and hernia recurrence (3/19) at mean follow-up of $28.7{\pm}22.8months$. With the exception of two patients with incomplete follow-up, all patients healed at a median time of 27 days. Conclusions This small, retrospective series of complex open CST in transplant patients shows acceptable rates of long-term hernia recurrence and healing. By using a multidisciplinary approach for abdominal wall reconstruction, we believe that modified open CST with biologic mesh is a safe and effective technique in the transplant population with complex abdominal hernias.

      • KCI등재

        Utility of a modified components separation for abdominal wall reconstruction in the liver and kidney transplant population

        Cara K Black,Elizabeth G Zolper,Elliot T Walters,Jessica Wang,Jesus Martinez,Andrew Tran,Iram Naz,Vikas Kotha,Paul J Kim,Sarah R Sher,Karen K. Evans 대한성형외과학회 2019 Archives of Plastic Surgery Vol.46 No.5

        Background Incisional hernia is a common complication following visceral organ transplantation. Transplant patients are at increased risk of primary and recurrent hernias due to chronic immune suppression and large incisions. We conducted a retrospective review of patients with a history of liver or kidney transplantation who underwent hernia repair to analyze outcomes and hernia recurrence. Methods This is a single center, retrospective review of 19 patients who received kidney and/or liver transplantation prior to presenting with an incisional hernia from 2011 to 2017. All hernias were repaired with open component separation technique (CST) with biologic mesh underlay. Results The mean age of patients was 61.0±8.3 years old, with a mean body mass index of 28.4±4.8 kg/m2, 15 males (78.9%), and four females (21.1%). There were seven kidney, 11 liver, and one combined liver and kidney transplant patients. The most common comorbidities were hypertension (16 patients, 84.2%), diabetes (9 patients, 47.4%), and tobacco use (8 patients, 42.1%). Complications occurred in six patients (31.6%) including hematoma (1/19), abscess (1/19), seroma (2/19), and hernia recurrence (3/19) at mean follow-up of 28.7±22.8 months. With the exception of two patients with incomplete follow-up, all patients healed at a median time of 27 days. Conclusions This small, retrospective series of complex open CST in transplant patients shows acceptable rates of long-term hernia recurrence and healing. By using a multidisciplinary approach for abdominal wall reconstruction, we believe that modified open CST with biologic mesh is a safe and effective technique in the transplant population with complex abdominal hernias.

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