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Design and implementation of AMD system for response control in tall buildings
J. Teng,H.B. Xing,Y.Q. Xiao,C.Y. Liu,H. Li,J.P. Ou 국제구조공학회 2014 Smart Structures and Systems, An International Jou Vol.13 No.2
This paper mainly introduces recently developed technologies pertaining to the design and implementation of Active Mass Damper (AMD) control system on a high-rise building subjected to wind load. Discussions include introduction of real structure and the control system, the establishment of analytical model, the design and optimization of a variety of controllers, the design of time-varying variable gain feedback control strategy for limiting auxiliary mass stroke, and the design and optimization of AMD control devices. The results presented in this paper demonstrate that the proposed AMD control systems can resolve the issues pertaining to insufficient floor stiffness of the building. The control system operates well and has a good sensitivity.
Design and implementation of AMD system for response control in tall buildings
Teng, J.,Xing, H.B.,Xiao, Y.Q.,Liu, C.Y.,Li, H.,Ou, J.P. Techno-Press 2014 Smart Structures and Systems, An International Jou Vol.13 No.2
This paper mainly introduces recently developed technologies pertaining to the design and implementation of Active Mass Damper (AMD) control system on a high-rise building subjected to wind load. Discussions include introduction of real structure and the control system, the establishment of analytical model, the design and optimization of a variety of controllers, the design of time-varying variable gain feedback control strategy for limiting auxiliary mass stroke, and the design and optimization of AMD control devices. The results presented in this paper demonstrate that the proposed AMD control systems can resolve the issues pertaining to insufficient floor stiffness of the building. The control system operates well and has a good sensitivity.
Positive regulation of β-catenin–PROX1 signaling axis by DBC1 in colon cancer progression
Yu, E J,Kim, S-H,Kim, H J,Heo, K,Ou, C-Y,Stallcup, M R,Kim, J H Nature Publishing Group 2016 Oncogene Vol.35 No.26
<P>Aberrant activation of Wnt/beta-catenin pathway contributes to colorectal cancer (CRC) progression. However, little is known about regulatory mechanisms of the beta-catenin activity in cancer progression. Here we investigated the role of DBC1, which was recently reported as a negative regulator of SIRT1 and a transcriptional coactivator, in the regulation of Wnt/beta-catenin signaling. We identified the genome-wide targets of DBC1 and found that loss of DBC1 inhibits the expression of beta-catenin target genes including PROX1, a transcription factor linked to CRC progression. Mechanistically, DBC1 stabilizes LEF1-beta-catenin interaction by inhibiting SIRT1-mediated beta-catenin deacetylation, thereby enhancing LEF1-beta-catenin complex formation and long-range chromatin looping at the PROX1 locus. Furthermore, DBC1 is also required for the transcriptional activity of PROX1, suggesting that DBC1 has a dual function in regulating beta-catenin-PROX1 signaling axis: as a coactivator for both beta-catenin and PROX1. Importantly, loss of DBC1 inhibited growth and tumorigenic potential of colon cancer cells, and DBC1 expression correlated with shorter relapse-free survival in patients with advanced CRC. Our results firmly establish DBC1 as a critical positive regulator of beta-catenin-PROX1 signaling axis and a key factor in beta-catenin-PROX1-mediated CRC progression.</P>
Kim, I.Y.,Modi, P.K.,Sadimin, E.,Ha, Y.S.,Kim, J.H.,Skarecky, D.,Cha, D.Y.,Wambi, C.O.,Ou, Y.C.,Yuh, B.,Park, S.,Llukani, E.,Albala, D.M.,Wilson, T.,Ahlering, T.,Badani, K.,Ahn, H.,Lee, D.I.,May, M.,K Williams and Wilkins Co 2013 The Journal of urology Vol.190 No.2
Purpose: Lymph nodes in the prostatic anterior fat pad rarely harbor metastatic disease. Therefore, the characteristics of patients with prostatic anterior fat pad lymph node metastasis are not well described in the literature. We identified the perioperative characteristics and assessed the clinical outcomes of patients with prostatic anterior fat pad lymph node metastasis. Materials and Methods: At 8 tertiary care centers a total of 4,261 patients underwent complete removal and pathological analysis of the prostatic anterior fat pad. We describe preoperative and pathological characteristics, and clinical management and outcomes in patients with metastatic disease to the prostatic anterior fat pad. Results: Metastatic disease to the prostatic anterior fat pad lymph nodes was detected in 40 patients (0.94%), of whom 37 (92.5%) had intermediate or high risk features preoperatively. Most patients with prostatic anterior fat pad metastases underwent concomitant pelvic lymph node dissection, and adjuvant therapy with radiation, androgen ablation and/or chemotherapy. A total of 27 patients (67.5%) with prostatic anterior fat pad metastatic disease were up-staged as a result of prostatic anterior fat pad pathological analysis, of whom 14 (51.8%) remained free of biochemical recurrence with observation and/or definitive adjuvant/salvage therapy. Conclusions: Most patients with prostatic anterior fat pad metastatic disease had intermediate to high risk features preoperatively. In some patients with such lymph node metastasis removing these lymph nodes resulted in prolonged biochemical recurrence-free survival. Therefore, we recommend that the prostatic anterior fat pad be removed in all patients undergoing radical prostatectomy. However, pathological analysis of the prostatic anterior fat pad may be limited to patients with intermediate to high risk oncological features preoperatively.
Structural damage identification using gravitational search algorithm
J.K. Liu,Z.T. Wei,Z.R. Lu,Y.J. Ou 국제구조공학회 2016 Structural Engineering and Mechanics, An Int'l Jou Vol.60 No.4
This study aims to present a novel optimization algorithm known as gravitational search algorithm (GSA) for structural damage detection. An objective function for damage detection is established based on structural vibration data in frequency domain, i.e., natural frequencies and mode shapes. The feasibility and efficiency of the GSA are testified on three different structures, i.e., a beam, a truss and a plate. Results show that the proposed strategy is efficient for determining the locations and the extents of structural damages using the first several modal data of the structure. Multiple damages cases in different types of structures are studied and good identification results can be obtained. The effect of measurement noise on the identification results is investigated.