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RISS 인기검색어
- 검색키워드
- 저자 : Issam Saliba (검색결과 3 건)
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Finite element modeling of rolled steel shapes subjected to weak axis bending
Najib G. Saliba,Issam Tawk,Antoine N. Gergess 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.29 No.2
Point bending is often used for cambering and curving structural steel girders. An analytical solution, applicable in the elasto-plastic range only, that relates applied loads to the desired curve was recently developed for inducing horizontal curves using four-point bending. This solution does not account for initial residual stresses and geometric imperfections built-in hotrolled sections. This paper presents results from a full-scale test on a hot-rolled steel section curved using four-point bending. In parallel, a numerical analysis, accounting for both initial geometric imperfections and initial residual stresses, was carried out. The models were validated against the experimental results and a good agreement for lateral offset and for strain in the elastoplastic and post-plastic ranges was achieved. The results show that the effect of initial residual stresses on deformation and strain is minimal. Finally, residual stresses due to cold bending calculated from the numerical analysis were assessed and a revised stress value for the service load design of the curved girder is proposed.
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Locacorten Vioform Ototoxicity Upon Guinea Pig Middle Ear Application
Owen Woods,Issam Saliba 대한청각학회 2018 Journal of Audiology & Otology Vol.22 No.2
Locacorten Vioform (Novartis UK) is frequently prescribed forotomycosis. Its component, Clioquinol, also has anti-bacterial properties. Up to this point, itsototoxic potential has not been evaluated. Our objective aims to evaluate Locacorten Vioform’spotential ototoxicity when applied directly to the middle ear cavity. Materials andMethods: We performed an experimental prospective animal study in our animal researchcenter with 20 Hartley guinea pigs divided into 2 groups. The first group (experimental) wastreated with Locacorten Vioform in one ear and with a physiologic saline solution in the other. The second group (positive control) was treated with concentrated gentamycin in one earand physiologic saline in the other. Auditory brainstem response measurements were obtainedbefore and after three sets of injections. Statistics were analyzed using a varianceanalysis with repeated measures. The histological state of cochlear outer hair cells was comparedbetween the two groups using scanning electron microscopy. Results: Average hearingloss in ears treated with Locacorten Vioform was 32.1 dB, compared with a 2.5 dB averageloss in the saline-treated ears. Ears treated with gentamycin lost an average of 33.0 dB. There were clinically and statistically significant differences between the two ears of the guineapigs in both groups (p<0.001). Scanning electron microscopy revealed severe pericochlearand cochlear inflammation and ossification in the Locacorten Vioform-treated ears. Gentamycin caused significant destruction of outer hair cell architecture. Conclusions: LocacortenVioform induces a hearing loss similar to that caused by gentamycin when applieddirectly to the middle ear of a guinea pig model. Electron microscopy indicates a pericochlearand cochlear inflammatory reaction with ossification.
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Sami Obaid,Ioannis Nikolaidis,Musaed Alzahrani,Robert Moumdjian,Issam Saliba 대한청각학회 2018 Journal of Audiology & Otology Vol.22 No.4
Background and Objectives: Controversy related to the choice of surgical approach for vestibular schwannoma (VS) resection remains. Whether the retrosigmoid (RS) or translabyrinthine (TL) approach should be performed is a matter of debate. In the context of a lack of clear evidence favoring one approach, we conducted a retrospective study to compare the morbidity rate of both surgical approaches. Subjects and Methods: 168 patients underwent surgical treatment (2007-2013) for VS at our tertiary care center. There were no exclusion criteria. Patients were separated into two groups according to the surgical approach: TL group and RS group. Signs and symptoms including ataxia, headache, tinnitus, vertigo and cranial nerve injuries were recorded pre- and postoperatively. Surgical complications were analyzed. Perioperative facial nerve function was measured according to House-Brackmann grading system. Results: Tumor resection was similar in both groups. Facial paresis was significantly greater in RS group patients preoperatively, in the immediate postoperative period and at one year follow-up (p<0.05). A constant difference was found between both groups at all three periods (p=0.016). The evolution of proportion was not found to be different between both groups (p=0.942), revealing a similar rate of surgically related facial paresis. Higher rate of ataxic gait (p=0.019), tinnitus (p=0.039) and cranial nerve injuries (p=0.016) was found in RS group patients. The incidence of headache, vertigo, vascular complications, cerebrospinal fluid leak and meningitis was similar in both groups. No reported mortality in this series. Conclusions: Both approaches seem similar in terms of resection efficacy. However, according to our analysis, the TL approach is less morbid. Thus, for VS in which hearing preservation is not considered, TL approach is preferable.
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