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Isamu Nishida,Masato Maeda,Tsuneo Kawano,Keiichi Shirase (사)한국CDE학회 2010 한국CAD/CAM학회 국제학술발표 논문집 Vol.2010 No.8
Factory automation and efficiency-oriented unmanned factories have become the major trend in manufacturing systems in recent years. However, human-centered manufacturing is gaining attention because of the flexibility it offers to manufacturing systems in terms of both product variety and volume. Although some digital human models capable of estimating the power generated by human muscles during various manufacturing-related tasks have been developed, a more effective method of analyzing muscle power is required to better estimate human muscle power. In the present study, a new musculoskeletal model taking the function of bi-articular muscles into consideration is applied to estimate the power generated by human muscles. The purpose of this study is to optimize working conditions that satisfy both the height of subjects and their maximum muscle power during a lifting operation. Results indicate the model is able to predict the heaviest weight and maximum height that this weight can be lifted to keep muscle power of the upper limb of a subject under 70% of the maximum muscle power. Moreover, the analyzed muscle power of the upper limb from experimental lifting operations is in good agreement optimized environments where humans can work efficiently and safely considering their physical characteristics.
Induction of allergic contact dermatitis by astigmatid mite-derived monoterpene, α-acaridial
Toshio Sasai,Yunosuke Hirano,Sayaka Maeda,Isamu Matsunaga,Atsushi Otsuka,Daisuke Morita,Ritsuo Nishida,Hideo Nakayama,Yasumasa Kuwahara,Masahiko Sugita,Naoki Mori 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.10
α-Acaridial [2(E)-(4-methyl-3-pentenyl)butenedial] is a novel monoterpene secreted from the house dust mites. Because of its molecular nature of a highly reactive, small lipidic compound, we addressed whether α-acaridial might function as a haptenic allergen that induced allergic contact dermatitis. Mice sensitized with α-acaridial were challenged by the same antigen on the ear skin. After 2 days, significant ear swelling with a prominent infiltration of CD4+ T lymphocytes was observed. In vitro, α-acaridial exhibited an outstanding ability to quickly interact with and chemically modify a reference protein. Virtually all cysteine residues and a sizable fraction of lysine residues were found to be selectively modified, suggesting that α-acaridial could potentially interact with any proteins. Previously, numerous mite-derived proteinaceous allergens have been associated with contact dermatitis. Our study now emphasizes that small lipidic compounds released from mites comprise a new class of mite allergens, and therefore, is of significant medical implications.