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학술 7 특별구두세션 : C5. 특별세션 품질선진기법 ; MCS(Monte Carlo Simulation)을 활용한 공정능력 예측
민경현 ( Kyung Hyun Min ),이레테크 ( Eretec Inc ) 한국품질경영학회 2014 한국품질경영학회 학술대회 Vol.2014 No.2
1. 목적 · Minitab Inc. 에서 클라우드 기반으로 개발한 몬테카를로 시뮬레이션 분석 툴인 Devize의 활용 방법 소개 2. 연구설계/ 방법론/ 정근방법 · Mintab의 실험계획법을 이용하여 반응식을 도출하고 도출된 반응식으로 몬테카를로 시뮬레이션을 적용하여 현재의 반응식으로 발생 가능한 공정능력 수준을 예측해 보고자 한다 시뮬레이션 툴로써 Minitab 사에서 출시 예정인 Devize를 활용하고자 한다. 3. 연구결과 · 공정에 영향을 미치는 입력 연수들에 대한 불확실성을 고려하여 보다 현실적인 공정능력을 예측해 볼 수 있으며 최적화를 통해서 우리의 공정의 개선 가능성을 판단해 볼 수 있다. 4. 실무적 시사점 · 간단한 툴을 이용하여 현업에서 쉽고 편리하게 시뮬레이션을 적용 업무에 활용해 볼 수 있음 5. 독창성/ 가치 · 기존의 평균 중심의 결정론적인 사고에서 시뮬레이션을 활용한 확률론적인 사고의 전환
Surajit Pathak,Alessia Rosaria Grillo,Melania Scarpa,Paola Brun,Renata D’Incà,Laura Nai,Antara Banerjee,Donatella Cavallo,Luisa Barzon,Giorgio Palù,Giacomo Carlo Sturniolo,Andrea Buda,Ignazio Castagli 생화학분자생물학회 2015 Experimental and molecular medicine Vol.47 No.-
Abnormal levels of microRNA (miR)-155, which regulate inflammation and immune responses, have been demonstrated in the colonic mucosa of patients with inflammatory bowel diseases (IBD), although its role in disease pathophysiology is unknown. We investigated the role of miR-155 in the acquisition and maintenance of an activated phenotype by intestinal myofibroblasts (IMF), a key cell population contributing to mucosal damage in IBD. IMF were isolated from colonic biopsies of healthy controls, ulcerative colitis (UC) and Crohn’s disease (CD) patients. MiR-155 in IMF was quantified by quantitative reverse transcription-PCR in basal condition and following exposure to TNF-α, interleukin (IL)-1β, lipopolysaccharide (LPS) or TGF-β1. The effects of miR-155 mimic or inhibitor transfection on cytokine release and suppressor of cytokine signaling 1 (SOCS1) expression were assessed by enzyme-linked immunosorbent assay and western blot, respectively. Regulation of the target gene SOCS1 expression by miR-155 was assessed using luciferase reporter construct. We found that miR-155 was significantly upregulated in UC as compared with control- and CD-derived IMF. Moreover, TNF-α and LPS, but not TGF-β1 and IL-1β, significantly increased miR-155 expression in IMF. Ectopic expression of miR-155 in control IMF augmented cytokines release, whereas it downregulated SOCS1 expression. MiR-155 knockdown in UC-IMF reduced cytokine production and enhanced SOCS1 expression. Luciferase reporter assay demonstrated that miR-155 directly targets SOCS1. Moreover, silencing of SOCS1 in control IMF significantly increased IL-6 and IL-8 release. In all, our data suggest that inflammatory mediators induce miR-155 expression in IMF of patients with UC. By downregulating the expression of SOCS1, miR-155 wires IMF inflammatory phenotype.
Ince, Serdar Turgut,Kumar, Ankush,Park, Dae Kyeom,Paik, Jeom Kee Elsevier 2017 International journal of impact engineering Vol.110 No.-
<P><B>Abstract</B></P> <P>The structural engineering problem associated with a ship colliding with an ice-ridge involves highly nonlinear mechanisms including buckling, collapse, crushing, plasticity and fracture together with environmental and operational factors, such as the loading speed (strain rate), temperature and salinity. The objective of this paper is to develop an advanced technology for numerical computations of structural crashworthiness in the event of a ship colliding with an ice-ridge. The nonlinear finite element method is used for modelling the problem, in which the ship structures are modelled by plate-shell finite elements and the ice-ridge structures are modelled by solid elements together with the KOSORI ice material models. Two sets of experiments are performed to validate the numerical computations. In the first set of experiments, ice is dropped on a steel plate from a height of 2m, and in the second, a steel solid (rigid) body is dropped on a steel plate under the same conditions. The results of the two experiments are compared to determine the differences between the ice responses and solid (rigid) body responses on the steel plate. It is concluded that the developed technology is very useful for computing the structural crashworthiness of a ship when colliding with an ice-ridge. Details of the test results are documented.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Nonlinear structural problems associated with a ship colliding with an ice-ridge are studied. </LI> <LI> Effects of buckling, collapse, crushing, plasticity and fracture together with environmental and operational factors, such as the loading speed (strain rate), temperature and salinity are taken into account. </LI> <LI> An advanced technology for numerical computations of structural crashworthiness in the event of a ship colliding with an ice-ridge is developed. </LI> <LI> The nonlinear finite element method is used for modelling the problem, in which the ship structures are modelled by plate-shell finite elements and the ice-ridge structures are modelled by solid elements together with the KOSORI ice material models. </LI> <LI> Two sets of experiments are performed to validate the numerical computations. </LI> <LI> It is concluded that the developed technology is very useful for computing the structural crashworthiness of a ship when colliding with an ice-ridge. </LI> </UL> </P>
Ince, Bilsev,Dadaci, Mehmet,Altuntas, Zeynep Korean Society of Plastic and Reconstructive Surge 2016 Archives of Plastic Surgery Vol.43 No.6
Background Although the use of temporary shunts in proximal extremity amputations has been reported, no study has described the use of temporary shunts in distal extremity amputations that require vein grafting. Moreover, the total volume of blood loss when temporary shunts are used has not been reported. The aim of this study was to investigate the applicability of a temporary shunt for distal extremity amputations requiring repair by vessel grafting with an ischemia time of >6 hours. This study also aimed to determine the total volume of blood loss when temporary shunts were used. Methods Patients who underwent distal major extremity replantation and/or revascularization with a vessel graft and who experienced ischemia for 6-8 hours between 2013 and 2014 were included in the study. A 6-Fr suction catheter was cut to 5 cm in length after the infusion of heparin, and secured with a 5-0 silk suture between the distal and the proximal ends of the artery. While bleeding continued, the bones were shortened and fixed. After the complete restoration of circulation, the arterial shunt created using the catheter was also repaired with a vein graft. Results Six patients were included in this study. The mean duration of ischemia was 7.25 hours. The mean duration of suction catheter use during limb revascularization was 7 minutes. The mean transfusion volume was 7.5 units. No losses of the extremity were observed. Conclusions This procedure should be considered in distal extremity amputations requiring repair by vessel grafting during critical ischemia.
Experimental design approach for ultra-fast nickel removal by novel bio-nanocomposite material
Ince, Olcay K.,Aydogdu, Burcu,Alp, Hevidar,Ince, Muharrem Techno-Press 2021 Advances in nano research Vol.10 No.1
In the present study, novel chitosan coated magnetic magnetite (Fe3O4) nanoparticles were successfully biosynthesized from mushroom, Agaricus campestris, extract. The obtained bio-nanocomposite material was used to investigate ultra-fast and highly efficient for removal of Ni2+ ions in a fixed-bed column. Chitosan was treated as polyelectrolyte complex with Fe3O4 nanoparticles and a Fungal Bio-Nanocomposite Material (FBNM) was derived. The FBNM was characterized by using X-Ray Diffractometer (XRD), Scanning Electron Microscopy-Energy Dispersive X-Ray Spectroscopy (SEM-EDS), Fourier Transform Infrared spectra (FTIR) and Thermogravimetric Analysis (TGA) techniques and under varied experimental conditions. The influence of some important operating conditions including pH, flow rate and initial Ni2+ concentration on the uptake of Ni2+ solution was also optimized using a synthetic water sample. A Central Composite Design (CCD) combined with Response Surface Modeling (RSM) was carried out to maximize Ni2+ removal using FBNM for adsorption process. A regression model was derived using CCD to predict the responses and analysis of variance (ANOVA) and lack of fit test was used to check model adequacy. It was observed that the quadratic model, which was controlled and proposed, was originated from experimental design data. The FBNM maximum adsorption capacity was determined as 59.8 mg g-1. Finally, developed method was applied to soft drinks to determine Ni2+ levels. Reusability of FBNM was tested, and the adsorption and desorption capacities were not affected after eight cycles. The paper suggests that the FBNM is a promising recyclable nanoadsorbent for the removal of Ni2+ from various soft drinks.