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      • KCI등재

        Design and In vitro and In vivo Characterization of Mucoadhesive Matrix Pellets of Metformin Hydrochloride for Oral Controlled Release: A Technical Note

        Pradum Pundlikrao Ige,Surendra Ganeshlal Gattani 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.3

        The aim of the current work was to design and develop matrix pellets of hydroxy propyl methyl cellulose K200M and microcrystalline cellulose in an admixture for a mucoadhesive gastroretentive drug delivery system. Pellets containing metformin hydrochloride (500 mg)were prepared by the pelletization technique using an extruder-spheronizer. Pellets were characterized by differential scanning calorimetry (DSC), x-ray diffraction (XRD), scanning electron microscopy (SEM), circularity, roundness, percent drug content, percent production yield, in vitro swelling, ex vivo mucoadhesion, in vitro drug release and in vivo x-ray imaging studies. Optimized pellets were sufficiently porous spheroids, free flowing, had smooth surfaces,had yields up to 75.45 ± 0.52% and had drug content up to 96.45 ± 0.19%. The average particle size of formulations MF2 and MF6 were 1.13 ± 0.41 mm and 1.22 ± 0.18 mm, respectively. Formulation MF6 exhibited strong adhesion, about 94.67%, to goat mucosal tissue, and the desired in vitro swelling, with a sustained drug release profile for 12 h and with retention in the upper small intestine of rabbits for 10 h. We conclude that hydroxy propyl methyl cellulose K200M and microcrystalline cellulose at a 2.80:1.00 w/w ratio could be an effective carrier for multiple unit controlled delivery of metformin hydrochloride.

      • KCI등재후보

        Seedling growth of Jatropha curcas L. at various levels of fertilizers in Nigeria

        P.O. Ige,B. Oyeleye,B.M. Awosusi 한국산림과학회 2011 Forest Science And Technology Vol.7 No.2

        This study assessed the effect of organic and inorganic fertilizers (cow dung and NPK 15:15:15) at different proportions on the early shoot growth of Jatropha curcas L. The fertilizers were applied with two weeks interval after transplanting from germination beds. Another set of seedlings were planted without fertilizer treatment, which served as the control. Growth parameters assessed for 10 weeks include shoot height, collar diameter and number of leaves. The growth parameters of J. curcas seedlings were significantly different among the fertilizer treatments at 5% probability level. The best growth of seedling was observed on the treatment of 100 g of NPK (15:15:15) þ 10 g of cow dung with the mean values of 31.83 cm for seedling height, 1.5 cm for collar diameter and 12 leaves. The results indicated that the increase of NPK fertilizer with organic fertilizer (cow dung) enhanced the growth and yield of J. curcas. A long-term fertilizer trial study under different agro-ecological regions is suggested because intended end use of J. curcas can be also economically viable and sustainably achieved with the use of fertilizers during plantation establishment.

      • KCI등재

        Nonlinear growth functions for modeling tree height–diameter relationships for Gmelina arborea (Roxb.) in south-west Nigeria

        P.O. Ige,G.O. Akinyemi,A.S. Smith 한국산림과학회 2013 Forest Science And Technology Vol.9 No.1

        Tree height–diameter relationship can be used as an important input component in forest growth and yield models, and description of stand dynamics. Five nonlinear growth functions were fitted to tree height–diameter data of a 21-year-old Gmelina arborea plantation in Ibadan, Nigeria. The data consisted of three sets obtained in 2004, 2008 and 2011 for total tree height and diameter at breast height (DBH). According to the model statistics, the five growth functions fitted the data equally well, but resulted in different asymptote estimates. Modified exponential fit was observed to give the best fit for the three data sets based on least square error, coefficient of determination and significance. The predicted values follow the same nonlinear pattern and formed close to the line of best fit without much outlier. The result of this study revealed that the ability of DBH in determining height is not strong enough based on the model’s goodness of fit and the model’s ability for predictive purposes. Hence, more variables such as age, crown area and soil fertility were recommended to be incorporated in future prediction of the tree height in the study area.

      • KCI등재

        Assessing remotely sensed temperature humidity index as human comfort indicator relative to landuse landcover change in Abuja, Nigeria

        Samuel O. Ige,Vincent O. Ajayi,O. E. Adeyeri,K. S. A. Oyekan 대한공간정보학회 2017 Spatial Information Research Vol.25 No.4

        Abuja, Nigeria’s capital city has witnessed remarkable expansion, growth and developmental activities since its inception in 1976. This mass inrush and settlement of people often leads to the replacement of the natural land cover with urban infrastructural facilities resulting in microclimate change and worsening thermal environmental conditions. It is therefore pertinent to study the thermal environment of the city if Abuja will avoid the associated problems of growing and expanding city like many others in the world. Thus this study examines the use of remote sensing and geographic information system in mapping the temperature humidity index (THI) as human comfort indicator relative to land use land cover change in Abuja using Landsat Thematic Mapper, Enhanced Thematic Mapper ? and Landsat 8 Operational Land Imager/Thermal Infrared Sensor data of 1987, 1999, 2009 and 2014. This is to assess the changes that have taken place between these periods. Subsequently, an attempt was made at comparing differences in the THI between five different land cover classes: water body, built-up area, closed canopy vegetation, open vegetation and waste land. The results show that the declining trend of vegetation cover between 1987–1999, and 2009–2014 saw a rise in the region with THI[26 (discomfort) while the periods between 1999 and 2009 where there was a remarkable improvement in the vegetation cover saw an increase in region where comfortable condition is achieved. The discomfort index class category is the most dominant across most of the land cover classes except in the water body and closed canopy class categories. This order of dominance is the highest in wasteland and built-up areas land use/land cover categories.

      • KCI등재

        Genetics of Testcrossed Streak Virus Resistance Carotene Quality Protein Maize

        Sunday Ayodele Ige,Bashir Omolaran Bello,Jimoh Mahamood,Michael Afolabi,Aremu Charity,Stephen Abolusoro,Abosede Victoria Adeniyi 한국육종학회 2023 Plant Breeding and Biotechnology Vol.11 No.3

        Development of Provitamin A quality protein maize (PVA-QPM) conferring resistance to maize streak virus (MSV)would reduce the prevalence of the disease, alleviate malnutrition and increase food security in sub-Saharan Africa. This study wasconducted to (i) evaluate early maturing PVA-QPM inbreds and their derived testcross hybrids for grain yield, MSV-resistant,carotenoids, and tryptophan contents, (ii) estimate the combining ability of the MSV-resistant PVA-QPM testcrosses for all traits. Fiveimproved open-pollinated MSV resistance cultivars and five early maturing PVA-QPM inbreds were crossed in a half-diallel fashionwithout reciprocals. The derived forty-five F1 topcrosses, ten parental materials, and two commercial hybrids that served as controlswere tested at the Lower Niger River Basin Development Authority in Oke-Oyi, Nigeria, during rain-fed of the year 2019 and 2020. ThePVA-QPM inbreds from TZEIORQ 13, TZEIORQ 29, and TZEQI 82 that were crossed with MSV resistance AK-9528-DMRSR andPop 28 SR appeared potentially useful combinations for enhancing grain yield, MSV-resistant, carotenoids, and tryptophan contents,Testcrossed TZEQI 82 × AK-9528-DMRSR POP 28 SR, TZEQI 82 × ACR. 91 SUWAN-1-SR C1 and TZEQI 82 × IK.91 TZL COMP3-Y C1 were most outstanding for all measured grain yield and nutrient contents. Additive genetic effects were preponderant overnon-additive genetic effects under artificial infection of MSV disease. These three promising MSV resistance PVA-QPM hybridsshould be evaluated under on-farm multiplication trials for stability performance and adaptation to reduce malnourishment and foodself-sufficiency in SSA. Also, further researches on genomic analyses of the superior testcrosses are desirable.

      • KCI등재

        Differential Response of Maize Inbreeding Depression to (Optimal and Stressed) Environments

        Sunday Ayodele Ige,Bashir Omolaran Bello,Jimoh Mahamood,Michael Afolabi,Aremu Charity,Stephen Abolusoro,Abosede Victoria Adeniyi 한국육종학회 2023 Plant Breeding and Biotechnology Vol.11 No.4

        Inbred lines generated from 10 maize population developed between 1979 and 2008 were used to investigate theinbreeding depression of tropical maize varieties developed at different breeding eras and evaluated in (optimal and stressed) condition. Across all the environments used for this study, estimates of inbred depression (I) for grain yield which ranged from 15.63% foroptimum environment to 35.85 under stem borer infestation, showed differences in the severity of the effects of practicing inbreedingin each of the populations and the different environments. The highest values of inbreeding depression for grain yield were recordedunder stem borer infestation. The effect of inbreeding was the most severe for var. DMR-LSR-W under borer infestation and least forDMR-LSR-Y in stress free environment. This is an indication that the responses of the maize populations to inbreeding as well as therate of attaining homozygosity differed with environments. Across the four different environments under which the genotypes wereevaluated, average inbreeding depression for grain yield were greater relative to other traits considered which should be expected sincegrain yield is a quantitatively inherited trait, governed by many genes each with minor effects.

      • KCI등재

        Gaseous Emission from the Combustion of Premium Motor Spirit (PMS) from the Kaduna Refinery and Petrochemical Company (KRPC) in Nigeria

        Osunnusi Oluwaseun Adedayo,Oke Michael Abidemi,Odekanle Ebenezer Leke,Sonibare Jacob Ademola,Ige Oluwafunmiso Ayodele,Oyewale Babatunde Oyeleke,Odewale Stephen Ayodele 대한환경공학회 2021 대한환경공학회지 Vol.43 No.5

        Objectives : This study characterizes the gaseous emission from the combustion of PMS of different volumes from Kaduna Refinery and Petrochemical Company. Methods : The E8500 plus combustion analyzer was used for gaseous emission characterization of different volumes. Oxygen (O2), Hydrocarbons (HC), carbon monoxide (CO), carbon dioxide (CO2), Oxides of Nitrogen NOx (NO, NO2), Sulphur dioxide (SO2), and Hydrogen Sulfide (H2S) were measured using the analyzer. The values were recorded and the descriptive statistics graph was plotted. Results and Discussion : The concentrations for the gaseous emission from the combustion of PMS were 69.85 mg/m3 HC, 117.33 mg/m3 CO, 334 mg/m3 NOx for 10 ml, 58.93 mg/m3 HC, 130.33 mg/m3 CO, 784.33 mg/m3 NOx for 20 ml, 50.20 mg/m3 HC, 84.00 mg/m3 CO, 798.67 mg/m3 NOx for 30 ml, 65.48 mg/m3 HC, 160.33 mg/m3 CO, 850.33 mg/m3 NOx for 40 ml, 87.31 mg/m3 HC, 212.67 mg/m3 CO, 801.33 mg/m3 NOx, 3.67 mg/m3 SO2 for 50 ml. This study shows that CO and HC exceeded the permissible limit for stationary sources while NOx and SO2 were below the permissible limit. Conclusions : Hence, there is a need for rapid response and urgent attention from government and regulatory bodies to develop and implement appropriate policies that will help in reducing the effect. Appropriate measures to control air emissions that may be embarked upon by regulatory bodies include increase in the use of low-emission fuels and renewable fuels such as bio-fuels and introduction of the use of devices with low CO emissions.

      • KCI등재

        Saponin from the fruit of Solanum anguivi protects against oxidative damage mediated by Fe2+ and sodium nitroprusside in rat brain synaptosome P2 fraction

        Olusola Olalekan Elekofehinti,Jean Paul Kamdem,Daiane Francine Meinerz,Ige Joseph Kade,Isaac Gbadura Adanlawo,Joa˜o Batista Teixeira Rocha 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.9

        Solanum anguivi fruit saponin has antidiabeticproperty via interference with cellular energy metabolismand inhibition of reactive oxygen species (ROS) generation. In the current study, brain specific in vitro anti-oxidantrole of S. anguivi saponin was investigated in the P2synaptosomal fraction of rat brain. Using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reductionassay, S. anguivi saponin concentration- dependently(10–200 lg/ml) reversed Fe2? and sodium nitroprussideinduceddecrease in mitochondrial activity via inhibition ofROS production, ROS-induced oxidation of protein andnon-protein thiol-containing molecules and lipid peroxidationas measured by thiobarbituric acid reactive substanceslevels. Conclusively, S. anguivi fruit saponin represents a class of natural compounds with the ability toreverse synaptosomal disruption, loss of mitochondrialintegrity and function often associated with the progressionof Huntington’s disease, Alzheimer disease, Parkinsondisease and amyotrophic lateral sclerosis diseases.

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