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Olusola Olalekan Elekofehinti,Jean Paul Kamdem,Daiane Francine Meinerz,Ige Joseph Kade,Isaac Gbadura Adanlawo,Joa˜o Batista Teixeira Rocha 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.9
Solanum anguivi fruit saponin has antidiabeticproperty via interference with cellular energy metabolismand inhibition of reactive oxygen species (ROS) generation. In the current study, brain specific in vitro anti-oxidantrole of S. anguivi saponin was investigated in the P2synaptosomal fraction of rat brain. Using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reductionassay, S. anguivi saponin concentration- dependently(10–200 lg/ml) reversed Fe2? and sodium nitroprussideinduceddecrease in mitochondrial activity via inhibition ofROS production, ROS-induced oxidation of protein andnon-protein thiol-containing molecules and lipid peroxidationas measured by thiobarbituric acid reactive substanceslevels. Conclusively, S. anguivi fruit saponin represents a class of natural compounds with the ability toreverse synaptosomal disruption, loss of mitochondrialintegrity and function often associated with the progressionof Huntington’s disease, Alzheimer disease, Parkinsondisease and amyotrophic lateral sclerosis diseases.