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AN INHIBITORY SUBSTANCE PRODUCED FROM ASPERGILLUS SP. ON THE HEMORRHAGIC ACTIVITIES OF SNAKE VENOMS
Seu, Jung Hwn,Lee, Sun Young,Lee, Sang Hwa 경북대학교 유전공학연구소 1995 遺傳工學硏究所報 Vol.10 No.1
An antihemorrhagic substance (ISH) was obtained from a cultured broth of Aspergillus sp.. The ISH partially purified with ion exchange resins had very strong antihemorrhagic activity against snake venoms. In this studies, five kinds of hemotrhagic fractions obtained from the venom of Agkistrodon blomhoffii brevicaudus by DEAE-Sephadex chromatography and the hemorrhage due to Rhobdophis tigrinus tigrinus venom were strongly inactivated by ISH. Also, the lethal and hemorrhagic activities of HR-I fraction of Trimeresurus fiavoviridis venom were remarkably inhibited by ISH.