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류마티스 관절염 환자에서 동반된 속발성 유전분증 1 예
김철수,김현대,김준희,이혜경,한성훈,이윤우,류재춘,김예희,정태기 대한내과학회 1995 대한내과학회지 Vol.49 No.4
A secondary amyloidosis is AA amyloidosis and rheumatoid arthritis is one of the main underlying diseases. We report a case of secondary amyloidosis in a patient with rhrumatoid arthritis. She had suffered from rheumatoid arthritis for 8years and her hands and feet were deformed. Hemoglobin was 8.7g /dl, hematocrit 25 vo1%, WBC 7700/mm³, ESR 44㎜/h. In urinalysis protein was 3+ and 20-25 RRC were seen in 400x microscopic field. Total protein of 24hour urine was 696 mg and Ccr was 62ml/ min. The blood BUN and creatinine level were normal. The serum level of rheumatoid factor was 316 IU/ml( $lt;40), CRP 1.1mg/dl and ANA test was negative. In abdominal sonography spleen, liver and kidneys were enlarged(spleen 15.1cm, right kidney 10.9cm, left kidney 12.2cm). A green colored positive birefringent amorphous material was found in polarizing microscopy of the rectal biopsy specimen stained with congo red. But the congo red staining of the specimen pretreated with potassium permanganate did`nt show any green birefringent material. We couldn't find any previous report of the secondary amyloidosis(AA amyloid)among the patients with rheumatoid arthritis in the Korean literatures.
김철수,김준희,정성광,송영수,이혜경,전영빈,강윤경,이윤우,김예희 대한내과학회 1996 대한내과학회지 Vol.51 No.3
Superficial migratory thrombophlebitis represents multiple, tender, often cord like nodules uaually on the legs but occasionally on the arms. It can be associated with internal malignancy or other systemic disease, such as varicose veins, thromboangitis obliterans, but also occurs idiopathically. Recently we experienced a patients with superficial migratory thrombophlebitis, chronic disseminated intravascular coagulation associated with adenocarcinoma of the stomach. A 35-year-old man was admitted to our hospital because of the pain and swelling of left lower leg for one month. An erythematous tender swelling along the superficial vein in above area was found and the skin biopsy disclosed perivascular lymphocytic infiltration and interstitial edema of subcutaneous tissue. Abdominal CT showed a localized ulcerating wall thickening involving the greater curvature of anterior wall of lower body of stomach, which was confirmed as adenocarcinoma with gastrofiberscopic biopsy. The blood level of FDP was increased and fibrinogen was decreased. The patient was discharged against advise of surgery.
Extremely small multimode-interference coupled triangular resonator with sharp angle of incidence
Kim, Doo Gun,Oh, Geum-Yoon,Choi, Woon-Kyung,Kim, Hyo Jin,Kim, Seon Hoon,Ki, Hyun Chul,Kim, Sang-Taek,Ko, Hang Ju,Kim, Tae Un,Yang, Myoung Hak,Kim, Hwe Jong,Yi, Jong Chang,Chung, Youngchul,Dagli, Nadir The Optical Society 2008 Optics express Vol.16 No.25
<P>Novel triangular ring resonators combining extremely small multimode-interference (MMI) coupler, low loss total internal reflection (TIR) mirrors, and semiconductor optical amplifiers are reported for the first time. The MMI length of 90 microm is among the shortest reported. The incidence angle of the TIR mirror inside the resonator is 22 degrees. A free-spectral range of approximately 2 nm is observed near 1550 nm along with an on-off ratio of 17 dB. The triangular resonators with a sharp angle are very attractive components due to their promise of compact size and high levels of integration. Therefore, large numbers of resonators can be integrated on a chip to increase functionality in future optical wavelength division multiplexing system.</P>
Chung Hwe Hoon,Seo Seung Hee,Kim Hyemin,Kim Yuil,Kim Dong Wuk,Lee Kwang Hyuck,Lee Kyu Taek,Heo Jin Seok,Han In Woong,Park Seon Mee,Jang Kee-Taek,Lee Jong Kyun,Park Joo Kyung 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.1
Background/Aims: Cholangiocarcinoma frequently recurs even after curative resection. Expression levels of proteins such as epidermal growth factor receptor (EGFR), Snail, epithelial cadherin (E-cadherin), and interleukin-6 (IL-6) examined by immunohistochemistry have been studied as potential prognostic factors for cholangiocarcinoma. The aim of this study was to investigate significant factors affecting the prognosis of resectable cholangiocarcinoma. Methods: Ninety-one patients who underwent surgical resection at Samsung Medical Center for cholangiocarcinoma from 1995 to 2013 were included in this study. Expression levels of E-cadherin, Snail, IL-6, membranous EGFR, and cytoplasmic EGFR were analyzed by immunohistochemistry using tissue microarray blocks made from surgical specimens. Results: Patients with high levels of membranous EGFR in tissue microarrays had significantly shorter overall survival (OS) and disease-free survival (DFS): high membranous EGFR (score 0–2) 38.0 months versus low membranous EGFR (score 3) 14.4 months (p=0.008) and high membranous EGFR (score 0–2) 23.2 months versus low membranous EGFR (score 3) 6.1 months (p=0.004), respectively. On the other hand, E-cadherin, Snail, cytoplasmic EGFR, and IL-6 did not show significant association with OS or DFS. Patients with distant metastasis had significantly higher IL-6 levels than those with locoregional recurrence (p=0.01). Conclusions: This study showed that overexpression of membranous EGFR was significantly associated with shorter OS and DFS in surgically resected bile duct cancer patients. In addition, higher IL-6 expression was a predictive marker for recurrence in cholangiocarcinoma patients with distant organ metastasis after surgical resection.