http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
David Hudgins,DENIZ GEVREK 연세대학교 동서문제연구원 2016 Global economic review Vol.45 No.2
This study uses an optimal tracking control framework to design a dynamic labor schedule that determines the optimal balance between labor, leisure, and consumption. The analysis generates proactive policy rules through deterministic, stochastic, robust, and compromise specifications of a Linear-Quadratic tracking model. Our model allows workers to optimally transition away from karoshi overwork and away from underemployment. Our study provides guidance for labor scheduling by quantitatively addressing the conflicts between health, work-life balance (WLB), and productivity. In Japan, this approach can be utilized by discussion bases and WLB initiatives, whereas the previous regulatory proposals for karoshi relief have created adversarial relationships that have not merged firm objectives with worker motives.
Kim, Hyun Joon,Gieske, Mary C,Hudgins, Susan,Kim, Beob Gyun,Krust, Andree,Chambon, Pierre,Ko, Chemyong Journal of Endocrinology, Ltd. [etc.] 2007 The Journal of endocrinology Vol.195 No.3
<P>Estrogen plays a critical role in inducing LH surge. In the pituitary, estrogen receptor alpha (ERalpha) mediates the action of estrogen, while the downstream pathway of ERalpha activation is yet to be elucidated. Here, we report the finding that cholecystokinin type A receptor (CCK-AR) is an ERalpha downstream gene in the mouse anterior pituitary. In the cycling mouse pituitary, the expression of CCK-AR mRNA is markedly higher in the afternoon of proestrus compared with metestrus. Both ovariectomy (OVX) and null mutation of the ERalpha gene completely abolish CCK-AR mRNA expression. Injection of 17beta-estradiol to OVX wild-type mice induces recovery of CCK-AR mRNA expression to levels observed at proestrus, but no such recovery is induced in OVX ERalpha knockout mice. The same pattern of estrogen dependency in inducing CCK-AR mRNA expression was seen in cultured primary anterior pituitary cells, indicating that estrogen directly acts on pituitary cells to induce CCK-AR expression. Immunohistological analysis revealed that more than 80% of gonadotrophs express CCK-AR in the afternoon of proestrus. To test whether CCK-AR mediated the sensitizing effect of estrogen in GnRH-induced LH secretion, primary pituitary cells were primed with estrogen followed by treatment with GnRH in the presence or absence of lorglumide, a CCK-AR antagonist. While both groups secreted LH upon GnRH treatment, lorglumide treatment significantly decreased LH secretion. Taken together, this study finds CCK-AR to be an ERalpha downstream gene in the pituitary and suggests that CCK-AR may play a role in the estrogen sensitization of the pituitary response to GnRH.</P>
Theca-specific estrogen receptor-alpha knockout mice lose fertility prematurely.
Lee, Sungeun,Kang, Dong-Wook,Hudgins-Spivey, Susan,Krust, Andree,Lee, Eun-Young,Koo, Youngbum,Cheon, Yongpil,Gye, Myung Chan,Chambon, Pierre,Ko, ChemYong Association for the Study of Internal Secretions 2009 Endocrinology Vol.150 No.8
<P>Estrogen receptor-alpha (Esr1) mediates estrogen action in regulating at all levels of the hypothalamic-pituitary-ovarian axis. Whereas the importance of Esr1 in hypothalamus and pituitary has been demonstrated by loss of fertility in the neuron- and pituitary-specific Esr1 knockout mice, whether Esr1 plays a critical role in the ovary remains to be determined. In the ovary, Esr1 is mainly expressed in the theca/interstitial cells and germinal epithelium and thus is believed to mediate estrogen action in these cells. In this study, we assessed the importance of Esr1 in the ovarian theca cells in regulating female reproduction. The Cre-LoxP approach was used to selectively delete the Esr1 gene in the theca cells, and the reproductive consequence of the deletion was measured. Adolescent theca-specific Esr1 knockout (thEsr1KO) mice (<4 months of age) are fertile and cycling. However, they begin to display an erratic pattern of estrous cycles and become infertile before they reach the age of 6 months. The ovaries of thEsr1KOmice (>or=4 months) have fewer corpora lutea but more antral follicles than the age-matching wild-type mice. The numbers of 17-hydroxylase-expressing cells are largely increased in the interstitium of the thEsr1KO mouse ovary. Interestingly, whereas basal levels of serum testosterone and FSH were mildly elevated, LH level was either markedly lower or undetectable in the thEsr1KO mice. When superstimulated by exogenous gonadotropins, thEsr1KO mice released significantly fewer oocytes that wild-type littermates and developed multiple hemorrhagic cysts. Taken together, this study demonstrates that theca Esr1 plays a critical role in regulating female reproduction.</P>